Results 11 to 20 of about 7,164,132 (254)

Multifunctional roles of Brl1-Brr6 in nuclear envelope fusion during nuclear pore complex biogenesis [PDF]

The EMBO Journal
Brl1 and Brr6 are integral membrane proteins of the yeast nuclear envelope (NE) that transiently associate with nuclear pore complexes (NPCs). The exact roles of Brl1 and Brr6 during NPC assembly are unclear.
Sayan Mondal, Annett Neuner, Azqa Ajmal Khan, Jlenia Vitale, Elmar Schiebel   +4 more
doaj   +2 more sources

Exon junction complex and nuclear pore complex components preferentially govern the nuclear export of spliced lncRNAs [PDF]

Cell Death Discovery
Long non-coding RNAs (lncRNAs) are crucial regulators of gene expression, but how spliced lncRNAs destined for the cytoplasm are exported from the nucleus remains unclear.
Sondas Saeed, Weijie Wang, Chaoqun Chen, Xiaokun Yuan, Siqi Zhao, Xin Xu, Xinyi Xu, Jiaxin Liu, Shuai Hou, Jinsong Yan, Haixin Lei   +10 more
doaj   +2 more sources

Nuclear warfare: pathogen manipulation of the nuclear pore complex and nuclear functions [PDF]

mBio
Viruses and bacteria exploit the nuclear pore complex (NPC) and host nuclear functions to bypass cellular barriers and manipulate essential processes. Viruses frequently engage directly with NPC components, such as nucleoporins, to enable genome import ...
Brianna Steiert, Mary M. Weber
doaj   +2 more sources

Nuclear pore complex dysfunction drives TDP-43 pathology in ALS [PDF]

Redox Biology
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron degeneration and pathological aggregation of TDP-43. While protein misfolding and impaired autophagy are established features, accumulating
O. Ramírez-Núñez, S. Rico-Ríos, P. Torres, V. Ayala, A. Fernàndez-Bernal, M. Ceron-Codorniu, P. Andrés-Benito, A. Vinyals, S. Maqsood, I. Ferrer, R. Pamplona, M. Portero-Otin   +11 more
doaj   +2 more sources

Nuclear pore complex proteins are involved in centromere distribution [PDF]

iScience
Summary: The subnuclear distribution of centromeres is cooperatively regulated by condensin II and the linker of nucleoskeleton and cytoskeleton (LINC) complex.
Nanami Ito, Takuya Sakamoto, Yuka Oko, Hikaru Sato, Shigeru Hanamata, Yuki Sakamoto, Sachihiro Matsunaga   +6 more
doaj   +2 more sources

A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis

Open Biology, 2021
The integral membrane protein Apq12 is an important nuclear envelope (NE)/endoplasmic reticulum (ER) modulator that cooperates with the nuclear pore complex (NPC) biogenesis factors Brl1 and Brr6. How Apq12 executes these functions is unknown.
Wanlu Zhang, Azqa Khan, Jlenia Vitale, Annett Neuner, Kerstin Rink, Christian Lüchtenborg, Britta Brügger, Thomas H. Söllner, Elmar Schiebel   +8 more
doaj   +1 more source

Nuclear pore complex and stem cell homeostasis

生物医学转化, 2021
As a channel for mediating exchange between the nucleus and cytoplasm, the nuclear pore complex (NPC) is a macromolecular complex composed of about 30 nucleoporins.
Li Lanzhu, Ji Zhejun, Zhang Weiqi, Qu Jing, Liu Guanghui   +4 more
doaj   +1 more source

Characterization of nuclear pore complex targeting domains in Pom152 in Saccharomyces cerevisiae

Biology Open, 2021
Pom152 is a transmembrane protein within the nuclear pore complex (NPC) of fungi that is important for NPC assembly and structure. Pom152 is comprised of a short amino-terminal region that remains on the cytosolic side of the nuclear envelope (NE) and ...
Jacqueline T. Brown, Alexandra J. Haraczy, Christopher M. Wilhelm, Kenneth D. Belanger   +3 more
doaj   +1 more source

The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei

Acta Neuropathologica Communications, 2021
Nuclear pore complex injury has recently emerged as an early and significant contributor to familial and sporadic ALS disease pathogenesis. However, the molecular events leading to this pathological phenomenon characterized by the reduction of specific ...
Alyssa N. Coyne, Jeffrey D. Rothstein
doaj   +1 more source

An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae

eLife, 2022
The nuclear pore complex (NPC) is the central portal for macromolecular exchange between the nucleus and cytoplasm. In all eukaryotes, NPCs assemble into an intact nuclear envelope (NE) during interphase, but the process of NPC biogenesis remains poorly ...
Annemarie Kralt, Matthias Wojtynek, Jonas S Fischer, Arantxa Agote-Aran, Roberta Mancini, Elisa Dultz, Elad Noor, Federico Uliana, Marianna Tatarek-Nossol, Wolfram Antonin, Evgeny Onischenko, Ohad Medalia, Karsten Weis   +12 more
doaj   +1 more source