Results 11 to 20 of about 6,851,273 (294)
The nuclear pore complex [PDF]
The Journal of cell biology, 1993 Over the past years, significant progress has been made both in the analysis of the structural and molecular organization of the nuclear pore complex (NPC) and the mechanism of nuclear transport. In this minireview, I will focus on some of the recent developments in this field.
Panté N, Aebi U
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Multifunctional roles of Brl1-Brr6 in nuclear envelope fusion during nuclear pore complex biogenesis [PDF]
The EMBO JournalBrl1 and Brr6 are integral membrane proteins of the yeast nuclear envelope (NE) that transiently associate with nuclear pore complexes (NPCs). The exact roles of Brl1 and Brr6 during NPC assembly are unclear.
Sayan Mondal +4 more
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Nuclear warfare: pathogen manipulation of the nuclear pore complex and nuclear functions [PDF]
mBioViruses and bacteria exploit the nuclear pore complex (NPC) and host nuclear functions to bypass cellular barriers and manipulate essential processes. Viruses frequently engage directly with NPC components, such as nucleoporins, to enable genome import ...
Brianna Steiert, Mary M. Weber
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The Structure of the Nuclear Pore Complex (An Update) [PDF]
Annual Review of Biochemistry, 2019 The nuclear pore complex (NPC) serves as the sole bidirectional gateway of macromolecules in and out of the nucleus. Owing to its size and complexity (∼1,000 protein subunits, ∼110 MDa in humans), the NPC has remained one of the foremost challenges for structure determination. Structural studies have now provided atomic-resolution crystal structures of
Daniel Lin, André Hoelz
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A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis
Open Biology, 2021 The integral membrane protein Apq12 is an important nuclear envelope (NE)/endoplasmic reticulum (ER) modulator that cooperates with the nuclear pore complex (NPC) biogenesis factors Brl1 and Brr6. How Apq12 executes these functions is unknown.
Wanlu Zhang +8 more
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Nuclear pore complex and stem cell homeostasis
生物医学转化, 2021 As a channel for mediating exchange between the nucleus and cytoplasm, the nuclear pore complex (NPC) is a macromolecular complex composed of about 30 nucleoporins.
Li Lanzhu +4 more
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Current Biology, 2003 What are they? Nuclear pore complexes (NPCs) are often referred to as the ‘gatekeepers of the nucleus’, being responsible for regulating the molecular traffic – from ions to ribosomes – between the nucleoplasm and the cytoplasm. A typical vertebrate nucleus has about 5,000 NPCs scattered over its surface.What do they look like? A picture is worth twice
Wozniak, Richard W, Lusk, C.Patrick
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Acta Neuropathologica Communications, 2021 Nuclear pore complex injury has recently emerged as an early and significant contributor to familial and sporadic ALS disease pathogenesis. However, the molecular events leading to this pathological phenomenon characterized by the reduction of specific ...
Alyssa N. Coyne, Jeffrey D. Rothstein
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Characterization of nuclear pore complex targeting domains in Pom152 in Saccharomyces cerevisiae
Biology Open, 2021 Pom152 is a transmembrane protein within the nuclear pore complex (NPC) of fungi that is important for NPC assembly and structure. Pom152 is comprised of a short amino-terminal region that remains on the cytosolic side of the nuclear envelope (NE) and ...
Jacqueline T. Brown +3 more
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An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae
eLife, 2022 The nuclear pore complex (NPC) is the central portal for macromolecular exchange between the nucleus and cytoplasm. In all eukaryotes, NPCs assemble into an intact nuclear envelope (NE) during interphase, but the process of NPC biogenesis remains poorly ...
Annemarie Kralt +12 more
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