Heat-induced gene positioning in "Caenorhabdidtis elegans" : "hsp-16" promoter drives transcription-dependent nuclear pore association [PDF]
, 2013 The DNA of eukaryotic cells is packaged into transcriptionally active euchromatin and repressed heterochromatin. These two chromatin types are non-randomly distributed within the nucleus. Indeed, at the nuclear periphery, heterochromatin is enriched near
Rohner, Sabine
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr
BMC Cell Biology, 2009 Background Tpr is a large protein with an extended coiled-coil domain that is localized within the nuclear basket of the nuclear pore complex. Previous studies 1 involving antibody microinjection into mammalian cells suggested a role for Tpr in nuclear ...
Frosst Phyllis D +2 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
gp210 proteins of Xenopus laevis nuclear pore complex stained with Alexa647
, 2021 Open in Shareloc.XYZXenopus laevis nuclear pore complex; gp210 proteins stained with Alexa647 (Uploaded via https://shareloc ...
Anna Löschberger
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Nuclear pore dysfunction and disease: a complex opportunity
NucleusThe separation of genetic material from bulk cytoplasm has enabled the evolution of increasingly complex organisms, allowing for the development of sophisticated forms of life. However, this complexity has created new categories of dysfunction, including
Charlotte M. Fare, Jeffrey D. Rothstein
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Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells.
PLoS ONE, 2011 Human DICER1 protein cleaves double-stranded RNA into small sizes, a crucial step in production of single-stranded RNAs which are mediating factors of cytoplasmic RNA interference. Here, we clearly demonstrate that human DICER1 protein localizes not only
Yoshinari Ando +14 more
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Expression of DNAJB12 or DNAJB14 causes coordinate invasion of the nucleus by membranes associated with a novel nuclear pore structure. [PDF]
PLoS ONE, 2014 DNAJB12 and DNAJB14 are transmembrane proteins in the endoplasmic reticulum (ER) that serve as co-chaperones for Hsc70/Hsp70 heat shock proteins. We demonstrate that over-expression of DNAJB12 or DNAJB14 causes the formation of elaborate membranous ...
Edward C Goodwin +4 more
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Components of coated vesicles and nuclear pore complexes share a common molecular architecture.
PLoS Biology, 2004 Numerous features distinguish prokaryotes from eukaryotes, chief among which are the distinctive internal membrane systems of eukaryotic cells. These membrane systems form elaborate compartments and vesicular trafficking pathways, and sequester the ...
Damien Devos +6 more
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