Results 81 to 90 of about 258,200 (289)

Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast. [PDF]

, 2019
Production of healthy gametes in meiosis relies on the quality control and proper distribution of both nuclear and cytoplasmic contents. Meiotic differentiation naturally eliminates age-induced cellular damage by an unknown mechanism.
Chetlapalli, Keerthana, Goodman, Jay S, Jorgens, Danielle M, King, Grant A, McDonald, Kent L, Schick, Jennifer G, Ünal, Elçin   +6 more
core   +1 more source

The Nuclear Pore Complex as a Flexible and Dynamic Gate [PDF]

, 2018
Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary transport gates for molecular exchange between nucleus and cytoplasm.
Knockenhauer, Kevin Edward, Schwartz, Thomas   +1 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Detailed characterisation of the trypanosome nuclear pore architecture reveals conserved asymmetrical functional hubs that drive mRNA export.

PLoS Biology
Nuclear export of mRNAs requires loading the mRNP to the transporter Mex67/Mtr2 in the nucleoplasm, controlled access to the pore by the basket-localised TREX-2 complex and mRNA release at the cytoplasmic site by the DEAD-box RNA helicase Dbp5 ...
Bernardo Papini Gabiatti, Johanna Krenzer, Silke Braune, Timothy Krüger, Martin Zoltner, Susanne Kramer   +5 more
doaj   +1 more source

The Potential of Nuclear Pore Complexes in Cancer Therapy

Molecules
Nuclear pore complexes (NPCs) play a critical role in regulating transport-dependent gene expression, influencing various stages of cancer development and progression.
Hanna Zaitsava, Martyna Gachowska, Elżbieta Bartoszewska, Alicja Kmiecik, Julita Kulbacka   +4 more
doaj   +1 more source

Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells.

PLoS ONE, 2011
Human DICER1 protein cleaves double-stranded RNA into small sizes, a crucial step in production of single-stranded RNAs which are mediating factors of cytoplasmic RNA interference. Here, we clearly demonstrate that human DICER1 protein localizes not only
Yoshinari Ando, Yoshinari Ando, Yasuhiro Tomaru, Ayako Morinaga, Alexander Maxwell Burroughs, Hideya Kawaji, Atsutaka Kubosaki, Ryuichiro Kimura, Maiko Tagata, Yoko Ino, Hisashi Hirano, Joe Chiba, Harukazu Suzuki, Piero Carninci, Yoshihide Hayashizaki   +14 more
doaj   +1 more source

The coordination of nuclear envelope assembly and chromosome segregation in metazoans

Nucleus, 2020
The nuclear envelope (NE) is composed of two lipid bilayer membranes that enclose the eukaryotic genome. In interphase, the NE is perforated by thousands of nuclear pore complexes (NPCs), which allow transport in and out of the nucleus. During mitosis in
Shiwei Liu, David Pellman
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Oxalate-Induced and Cell-Cycle-Dependent Expression of Nuclear Pore Complex Oxalate Binding Protein gp210 [PDF]

, 1999
The effect of oxalate, a constituent of renal stone, on the expression of nuclear pore complex oxalate binding protein (gp210) in Vero monkey kidney cells was examined.
Kannapiran, M, Selvam, R, Vijaya, R
core  

NOX2, p22phox and p47phox are targeted to the nuclear pore complex in ischemic cardiomyocytes colocalizing with local reactive oxygen species. [PDF]

, 2011
BACKGROUND: NADPH oxidases play an essential role in reactive oxygen species (ROS)-based signaling in the heart. Previously, we have demonstrated that (peri)nuclear expression of the catalytic NADPH oxidase subunit NOX2 in stressed cardiomyocytes, e.g ...
Akki A, Albert C. van Rossum, Allen RG, Babior BM, Babior BM, Beck M, Beck M, Bedard K, Bernad R, Calafat J, Christof Meischl, D'Angelo MA, D'Angelo MA, Duncan MW, El Benna J, Finkel T, Finkel T, Ghezzi P, Groemping Y, Hans W.M. Niessen, Hans W.R.M. Janssen, Held JM, Ito N, Kagiyama S, Kobayashi N, Kohler A, Krijnen PA, Krijnen PA, Lambeth JD, Laufs U, Li JM, Maack C, Maarten Fornerod, Maulik N, Meischl C, Moir RD, Morel Y, Nynke E. Hahn, Ostuni MA, Patre M, Paul A.J. Krijnen, Paul J.M. Wijnker, Rene J.P. Musters, Rogers LD, Sipkens JA, Strambio-De-Castillia C, Terada LS, Touyz RM, Ushio-Fukai M, Verhoeven AJ, Vignais PV, Walter J. Paulus, Wosniak, Wu RF, Wu RF   +54 more
core   +1 more source