Modelling Nuclear Morphology and Shape Transformation: A Review [PDF]
Membranes, 2021 As one of the most important cellular compartments, the nucleus contains genetic materials and separates them from the cytoplasm with the nuclear envelope (NE), a thin membrane that is susceptible to deformations caused by intracellular forces ...
Chao Fang +3 more
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How the chromatin landscape influences nuclear morphology [PDF]
Frontiers in Cell and Developmental BiologyNuclear morphology is a defining cellular feature, differing based on cell type, tissue type, and species. In healthy cells, nuclear morphology is generally tightly regulated and maintained; however, dynamic changes in nuclear morphology are observed ...
Sourabh Sengupta +2 more
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Nuclear morphology predicts cell survival to cisplatin chemotherapy [PDF]
Neoplasia: An International Journal for Oncology Research, 2023 The emergence of chemotherapy resistance drives cancer lethality in cancer patients, with treatment initially reducing overall tumor burden followed by resistant recurrent disease.
Chi-Ju Kim +7 more
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Editorial: Nuclear morphology in development and disease [PDF]
Frontiers in Cell and Developmental Biology, 2023 Tanmay P. Lele +4 more
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B Cells Adapt Their Nuclear Morphology to Organize the Immune Synapse and Facilitate Antigen Extraction [PDF]
Frontiers in Immunology, 2022 Upon interaction with immobilized antigens, B cells form an immune synapse where actin remodeling and re-positioning of the microtubule-organizing center (MTOC) together with lysosomes can facilitate antigen extraction.
Romina Ulloa +12 more
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Region-specific heterogeneity in neuronal nuclear morphology in young, aged and in Alzheimer’s disease mouse brains [PDF]
Frontiers in Cell and Developmental Biology, 2023 Neurons in the mammalian brain exhibit enormous structural and functional diversity across different brain regions. Compared to our understanding of the morphological diversity of neurons, very little is known about the heterogeneity of neuronal nuclear ...
Soumen Das, Narendrakumar Ramanan
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Effects of Myostatin on Nuclear Morphology at the Myotendinous Junction. [PDF]
Int J Mol Sci, 2023 Myostatin (Myo) is known to suppress skeletal muscle growth, and was recently reported to control tendon homeostasis. The purpose of the present study was to investigate the regulatory involvement of Myo in the myotendinous junction (MTJ) in vivo and in vitro.
Amemiya H +9 more
europepmc +3 more sources
Two nondimensional parameters for characterizing the nuclear morphology. [PDF]
Biophys J, 2021 Nuclear morphology is an important indicator of cell function. It is regulated by a variety of factors such as the osmotic pressure difference between the nucleoplasm and cytoplasm, cytoskeletal forces, elasticity of the nuclear envelope and chromosomes.
Balakrishnan S +4 more
europepmc +3 more sources
Cell shape dependent regulation of nuclear morphology [PDF]
Biomaterials, 2015 Recent studies suggest that actin filaments are essential in how a cell controls its nuclear shape. However, little is known about the relative importance of membrane tension in determining nuclear morphology. In this study, we used adhesive micropatterned substrates to alter the cellular geometry (aspect ratio, size, and shape) that allowed direct ...
Chia-Chi Ho
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An RNAi screen for genes that affect nuclear morphology in Caenorhabditis elegans reveals the involvement of unexpected processes [PDF]
G3: Genes, Genomes, Genetics, 2021 Aberration in nuclear morphology is one of the hallmarks of cellular transformation. However, the processes that, when mis-regulated, result aberrant nuclear morphology are poorly understood.
Richa Maheshwari +3 more
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