B Cells Adapt Their Nuclear Morphology to Organize the Immune Synapse and Facilitate Antigen Extraction [PDF]
Frontiers in Immunology, 2022 Upon interaction with immobilized antigens, B cells form an immune synapse where actin remodeling and re-positioning of the microtubule-organizing center (MTOC) together with lysosomes can facilitate antigen extraction.
Romina Ulloa +12 more
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Region-specific heterogeneity in neuronal nuclear morphology in young, aged and in Alzheimer’s disease mouse brains [PDF]
Frontiers in Cell and Developmental Biology, 2023 Neurons in the mammalian brain exhibit enormous structural and functional diversity across different brain regions. Compared to our understanding of the morphological diversity of neurons, very little is known about the heterogeneity of neuronal nuclear ...
Soumen Das, Narendrakumar Ramanan
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How the chromatin landscape influences nuclear morphology [PDF]
Frontiers in Cell and Developmental BiologyNuclear morphology is a defining cellular feature, differing based on cell type, tissue type, and species. In healthy cells, nuclear morphology is generally tightly regulated and maintained; however, dynamic changes in nuclear morphology are observed ...
Sourabh Sengupta +2 more
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Nuclear morphology predicts cell survival to cisplatin chemotherapy [PDF]
Neoplasia: An International Journal for Oncology Research, 2023 The emergence of chemotherapy resistance drives cancer lethality in cancer patients, with treatment initially reducing overall tumor burden followed by resistant recurrent disease.
Chi-Ju Kim +7 more
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An RNAi screen for genes that affect nuclear morphology in Caenorhabditis elegans reveals the involvement of unexpected processes [PDF]
G3: Genes, Genomes, Genetics, 2021 Aberration in nuclear morphology is one of the hallmarks of cellular transformation. However, the processes that, when mis-regulated, result aberrant nuclear morphology are poorly understood.
Richa Maheshwari +3 more
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Modelling Nuclear Morphology and Shape Transformation: A Review [PDF]
Membranes, 2021 As one of the most important cellular compartments, the nucleus contains genetic materials and separates them from the cytoplasm with the nuclear envelope (NE), a thin membrane that is susceptible to deformations caused by intracellular forces ...
Chao Fang +3 more
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Self-supervised pretraining with NuSPIRe unlocks nuclear morphology-driven insights in spatial omics [PDF]
Genome BiologyNuclear morphology encodes rich phenotypic information critical for understanding cellular states, yet its full potential remains untapped in biomedical analysis.
Yuwei Hua, Shiyu Li, Yong Zhang
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Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP [PDF]
Journal of Experimental & Clinical Cancer Research, 2022 Background Lamins, key nuclear lamina components, have been proposed as candidate risk biomarkers in different types of cancer but their accuracy is still debated.
Mattia La Torre +13 more
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Editorial: Nuclear morphology in development and disease [PDF]
Frontiers in Cell and Developmental Biology, 2023 Tanmay P. Lele +4 more
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Utility of White Blood Cell Diluting Fluid (Turk’s Fluid) in Evaluation of Haemorrhagic Thyroid Cytology Smears in a Tertiary Care Centre- A Novel Study [PDF]
Journal of Clinical and Diagnostic Research, 2022 Introduction: Fine Needle Aspiration Cytology (FNAC) has been one of the safest and accurate diagnostic technique in diagnosing thyroid lesions. But due to the vascularity of thyroid tissue, diagnostic cells get entrapped in blood clot unless rapid ...
Amrutha Gorva +3 more
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