Nuclear morphology predicts cell survival to cisplatin chemotherapy. [PDF]
Neoplasia, 2023 AbstractIn this study, we characterized nuclear morphology and function as cancer cells underwent recovery following chemotherapeutic treatment to identify the unique characteristics associated with treatment resistance and successful survival.
Kim CJ +7 more
europepmc +6 more sources
Dermatofibroma Versus Dermatofibrosarcoma Protuberans: A Nuclear Morphology Study. [PDF]
Am J Dermatopathol, 2023 Abstract: The locally invasive soft-tissue sarcoma, dermatofibrosarcoma protuberans (DFSPs), shares certain histologic features of the much more common and benign dermatofibroma (DF). While immunohistochemical stains, specifically cluster of differentiation 34 and Factor XIIIa, can be used to distinguish the 2 entities using microscopy, these
Khamdan F +5 more
europepmc +3 more sources
Modelling Nuclear Morphology and Shape Transformation: A Review. [PDF]
Membranes (Basel), 2021 As one of the most important cellular compartments, the nucleus contains genetic materials and separates them from the cytoplasm with the nuclear envelope (NE), a thin membrane that is susceptible to deformations caused by intracellular forces. Interestingly, accumulating evidence has also indicated that the morphology change of NE is tightly related ...
Fang C, Yao J, Xia X, Lin Y.
europepmc +5 more sources
Morphology of the Nuclear Disk in M87 [PDF]
, 1998 A deep, fuly sampled diffraction limited (FWHM ~ 70 mas) narrow-band image of the central region in M87 was obtained with the Wide Filed and Planetary Camera 2 of the Hubble Space Telescope using the dithering technique.
H. C. Ford +4 more
core +5 more sources
Two nondimensional parameters for characterizing the nuclear morphology. [PDF]
Biophys J, 2021 Nuclear morphology is an important indicator of cell function. It is regulated by a variety of factors such as the osmotic pressure difference between the nucleoplasm and cytoplasm, cytoskeletal forces, elasticity of the nuclear envelope and chromosomes.
Balakrishnan S +4 more
europepmc +3 more sources
Medicago LINC complexes function in nuclear morphology, nuclear movement, and root nodule symbiosis 1[OPEN] [PDF]
Plant Physiology, 2018 Nuclear movement is involved in cellular and developmental processes across eukaryotic life, often driven by Linker of Nucleoskeleton and Cytoskeleton (LINC) complexes, which bridge the nuclear envelope (NE) via the interaction of Klarsicht/ ANC-1/Syne-1
Cerro Sánchez, Pablo del +3 more
core +4 more sources
Editorial: Nuclear morphology in development and disease. [PDF]
Front Cell Dev Biol, 2023 Lele TP, Levy DL, Mishra K.
europepmc +4 more sources
Nuclear morphology is shaped by loop-extrusion programs. [PDF]
NatureIt is well established that neutrophils adopt malleable polymorphonuclear shapes to migrate through narrow interstitial tissue spaces1-3. However, how polymorphonuclear structures are assembled remains unknown4. Here we show that in neutrophil progenitors, halting loop extrusion-a motor-powered process that generates DNA loops by pulling in chromatin5 ...
Patta I +13 more
europepmc +5 more sources
Keratin 17 regulates nuclear morphology and chromatin organization. [PDF]
J Cell Sci, 2020 AbstractKeratin 17 (KRT17; K17), a non-lamin intermediate filament protein, was recently found to occur in the nucleus. We report here on K17-dependent differences in nuclear morphology, chromatin organization, and cell proliferation. Human tumor keratinocyte cell lines lacking K17 exhibit flatter nuclei relative to normal.
Jacob JT +6 more
europepmc +3 more sources
Role of Lamin A and emerin in maintaining nuclear morphology in different subtypes of ovarian epithelial cancer. [PDF]
Oncol Lett, 2022 Watabe S +8 more
europepmc +3 more sources