Results 11 to 20 of about 2,913,267 (246)

The Combination of Berberine and Methotrexate Enhances Anti-Cancer Effects in Hela Cancer Cell Line: A Morphological Study [PDF]

Pharmaceutical Sciences, 2021
Background: Co-administration of two or several either chemotherapeutic agents or conventional drugs as a combination treatment is the most effective method to increase therapeutic efficiency. Additive or synergistic influence are two mechanisms by which
Hossein Majidzadeh, Mostafa Araj-Khodaei, Maryam Ghaffari, Amir Jafari, Dariush Shanehbandi, Mohammadali Torbati, Jafar Ezzati Nazhad Dolatabadi   +6 more
doaj   +1 more source

Negative correlation between the nuclear size and nuclear Lamina component Lamin A in intraductal papillary mucinous neoplasms of the pancreas

Pathology and Oncology Research, 2022
Background: The nuclear laminar protein Lamin A and inner nuclear membrane protein Emerin plays important role in sustaining nuclear structure. However, They have not investigated the significance of these proteins for development of pancreatic ...
Tamaki Hiroe, Shunichi Moriya, Sayaka Kobayashi, Yoshimi Nishijima, Akira Watanabe, Ken Shirabe, Hayato Ikota, Hideaki Yokoo, Masanao Saio   +8 more
doaj   +1 more source

Phytochemical Analysis and In Vitro Cytotoxic Activity against Colorectal Adenocarcinoma Cells of Hippophae rhamnodies L., Cymbopogon citratus (D.C.) Stapf, and Ocimum basilicum L. Essential Oils

Plants, 2021
Colorectal carcinoma (CRC) is one of the most frequently diagnosed cancer types with current deficient and aggressive treatment options, but various studied alternative therapies are able to efficiently contribute to its management.
Alina Dolghi, Roxana Buzatu, Amadeus Dobrescu, Flavius Olaru, Grigore Alexandru Popescu, Iasmina Marcovici, Iulia Pinzaru, Dan Navolan, Octavian Marius Cretu, Iuliana Popescu, Cristina Adriana Dehelean   +10 more
doaj   +1 more source

Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients

Frontiers in Cell and Developmental Biology, 2023
Primary fibroblasts from patient’s skin biopsies are directly isolated without any alteration in the genome, retaining in culture conditions their endogenous cellular characteristics and biochemical properties.
Saja Gharaba, Omri Paz, Lea Feld, Anastasia Abashidze, Maydan Weinrab, Noam Muchtar, Adam Baransi, Aviv Shalem, Aviv Shalem, Aviv Shalem, Uri Sprecher, Lior Wolf, Haguy Wolfenson, Miguel Weil   +13 more
doaj   +1 more source

Nuclear mechanosignaling in striated muscle diseases

Frontiers in Physiology, 2023
Mechanosignaling describes processes by which biomechanical stimuli are transduced into cellular responses. External biophysical forces can be transmitted via structural protein networks that span from the cellular membrane to the cytoskeleton and the ...
Bo Zhang, Joseph D. Powers, Andrew D. McCulloch, Andrew D. McCulloch, Neil C. Chi, Neil C. Chi, Neil C. Chi, Neil C. Chi   +7 more
doaj   +1 more source

Nuclear Dynamics and Chromatin Structure: Implications for Pancreatic Cancer

Cells, 2021
Changes in nuclear shape have been extensively associated with the dynamics and functionality of cancer cells. In most normal cells, nuclei have a regular ellipsoid shape and minimal variation in nuclear size; however, an irregular nuclear contour and ...
Luis F. Flores, Brooke R. Tader, Ezequiel J. Tolosa, Ashley N. Sigafoos, David L. Marks, Martin E. Fernandez-Zapico   +5 more
doaj   +1 more source

Current Methods and Pipelines for Image-Based Quantitation of Nuclear Shape and Nuclear Envelope Abnormalities

Cells, 2022
Any given cell type has an associated “normal” nuclear morphology, which is important to maintain proper cellular functioning and safeguard genomic integrity.
Anne F. J. Janssen, Sophia Y. Breusegem, Delphine Larrieu   +2 more
doaj   +1 more source

Morphometric analysis of suprabasal cell layer in oral epithelial dysplasia: A computer-assisted microscopic study

Journal of Pharmacy and Bioallied Sciences, 2020
Background: Oral leukoplakia is the most common precancerous lesion. Various grading systems based on histological findings have been proposed for dysplasia.
Viswanathan Prema, Thomson Thomas, Prasad Harikrishnan, Mani Viswanathan, Kenniyan Kumar Srichinthu, Krishnan Rajkumar   +5 more
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Chromatin integrity, nuclear morphology and protamine content.

, 2022
A) Agarose gel of DNA extracted from WT, Prm2+/-, Prm2-/- and Prm2+/Δc mature sperm. B) Comparison of mature sperm nucleus consensus shapes of WT, Prm2+/-, Prm2-/-, Prm2+/Δc and Prm2-/Δc resulting from nuclear morphology analysis.
Lena Arévalo (8148903), Simon Schneider (749180), Isabelle Sophie Neumann (12969420), Hubert Schorle (15757), Gina Esther Merges (12969414), Franka Enow Oben (12969417)   +5 more
core   +1 more source

Identification of epigenetic modulators as determinants of nuclear size and shape

eLife, 2023
The shape and size of the human cell nucleus is highly variable among cell types and tissues. Changes in nuclear morphology are associated with disease, including cancer, as well as with premature and normal aging.
Andria C Schibler, Predrag Jevtic, Gianluca Pegoraro, Daniel L Levy, Tom Misteli   +4 more
doaj   +1 more source