Results 11 to 20 of about 446,559 (292)

Recent advances in understanding plant nuclear envelope proteins involved in nuclear morphology [PDF]

Journal of Experimental Botany, 2015
The nuclear envelope (NE) is a fundamental structure of the nucleus and plays an important role in nuclear morphology through the strict regulation of NE protein function. Beyond its physical barrier function between nucleoplasm and cytoplasm, recent studies of the plant NE have provided novel insights into basic aspects of nuclear morphology as well ...
Kentaro Tamura, Ikuko Hara-Nishimura, Chieko Gotō   +2 more
exaly   +6 more sources

Cytological evaluation of thyroid lesions by nuclear morphology and nuclear morphometry

Journal of Cytology, 2017
Introduction: Fine needle aspiration (FNA) of the thyroid gland is an effective diagnostic method. The Bethesda system for reporting thyroid cytopathology classifies them into six categories and gives implied risk for malignancy and management protocol ...
R Yashaswini, T N Suresh, A Sagayaraj
doaj   +3 more sources

Self-supervised pretraining with NuSPIRe unlocks nuclear morphology-driven insights in spatial omics [PDF]

Genome Biology
Nuclear morphology encodes rich phenotypic information critical for understanding cellular states, yet its full potential remains untapped in biomedical analysis.
Yuwei Hua, Shiyu Li, Yong Zhang
doaj   +2 more sources

Characterization of nuclear morphology and nuclear matrices in ageing human fibroblasts

Mechanisms of Ageing and Development, 1992
It is believed that the mechanisms for cellular senescence may reside within the genome, however, the changes which occur in the DNA and the surrounding nuclear environment have not been well documented. As the dynamic skeletal framework of the nucleus, the nuclear matrix is poised to play a critical role in the ageing process. The nuclear matrix plays
Kenneth Pienta, Donald S Coffey, R H Getzenberg   +2 more
exaly   +3 more sources

Lamin A and microtubules collaborate to maintain nuclear morphology [PDF]

Nucleus, 2017
Lamin A (LA) is a critical structural component of the nuclear lamina. Mutations within the LA gene (LMNA) lead to several human disorders, most striking of which is Hutchinson-Gilford Progeria Syndrome (HGPS), a premature aging disorder. HGPS cells are best characterized by an abnormal nuclear morphology known as nuclear blebbing, which arises due to ...
Zeshan Tariq, Haoyue Zhang, Alexander Chia-Liu, Yang Shen, Yantenew Gete, Zheng-Mei Xiong, Claire Tocheny, Leonard Campanello, Di Wu, Wolfgang Losert, Kan Cao   +10 more
openaire   +4 more sources

Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP [PDF]

Journal of Experimental & Clinical Cancer Research, 2022
Background Lamins, key nuclear lamina components, have been proposed as candidate risk biomarkers in different types of cancer but their accuracy is still debated.
Mattia La Torre, Chiara Merigliano, Klizia Maccaroni, Alexandre Chojnowski, Wah Ing Goh, Maria Giubettini, Fiammetta Vernì, Cristina Capanni, Daniela Rhodes, Graham Wright, Brian Burke, Silvia Soddu, Romina Burla, Isabella Saggio   +13 more
doaj   +2 more sources

Nuclear morphology is shaped by loop-extrusion programs. [PDF]

Nature
It is well established that neutrophils adopt malleable polymorphonuclear shapes to migrate through narrow interstitial tissue spaces1-3. However, how polymorphonuclear structures are assembled remains unknown4. Here we show that in neutrophil progenitors, halting loop extrusion-a motor-powered process that generates DNA loops by pulling in chromatin5 ...
Patta I, Zand M, Lee L, Mishra S, Bortnick A, Lu H, Prusty A, McArdle S, Mikulski Z, Wang HY, Cheng CS, Fisch KM, Hu M, Murre C.   +13 more
europepmc   +5 more sources

Farnesylated Nuclear Proteins Kugelkern and Lamin Dm0 Affect Nuclear Morphology by Directly Interacting with the Nuclear Membrane [PDF]

Molecular Biology of the Cell, 2010
Nuclear shape changes are observed during a variety of developmental processes, pathological conditions, and ageing. The mechanisms underlying nuclear shape changes in the above-mentioned situations have mostly remained unclear. To address the molecular mechanism behind nuclear shape changes, we analyzed how the farnesylated nuclear envelope proteins ...
Polychronidou, Maria, Hellwig, Andrea, Grosshans, Joerg   +2 more
openaire   +5 more sources

Utility of White Blood Cell Diluting Fluid (Turk’s Fluid) in Evaluation of Haemorrhagic Thyroid Cytology Smears in a Tertiary Care Centre- A Novel Study [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Fine Needle Aspiration Cytology (FNAC) has been one of the safest and accurate diagnostic technique in diagnosing thyroid lesions. But due to the vascularity of thyroid tissue, diagnostic cells get entrapped in blood clot unless rapid ...
Amrutha Gorva, KL Shoba, K Chaithanya, V Arpitha   +3 more
doaj   +1 more source

The Combination of Berberine and Methotrexate Enhances Anti-Cancer Effects in Hela Cancer Cell Line: A Morphological Study [PDF]

Pharmaceutical Sciences, 2021
Background: Co-administration of two or several either chemotherapeutic agents or conventional drugs as a combination treatment is the most effective method to increase therapeutic efficiency. Additive or synergistic influence are two mechanisms by which
Hossein Majidzadeh, Mostafa Araj-Khodaei, Maryam Ghaffari, Amir Jafari, Dariush Shanehbandi, Mohammadali Torbati, Jafar Ezzati Nazhad Dolatabadi   +6 more
doaj   +1 more source