Results 11 to 20 of about 809,360 (285)

Cell shape dependent regulation of nuclear morphology [PDF]

Biomaterials, 2015
Recent studies suggest that actin filaments are essential in how a cell controls its nuclear shape. However, little is known about the relative importance of membrane tension in determining nuclear morphology. In this study, we used adhesive micropatterned substrates to alter the cellular geometry (aspect ratio, size, and shape) that allowed direct ...
Bo, Chen, Carlos, Co, Chia-Chi, Ho
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Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology [PDF]

Nature Communications, 2017
AbstractThe distinct spatial architecture of the apical actin cables (or actin cap) facilitates rapid biophysical signaling between extracellular mechanical stimuli and intracellular responses, including nuclear shaping, cytoskeletal remodeling, and the mechanotransduction of external forces into biochemical signals.
Jeong-Ki Kim, Arghavan Louhghalam, Geonhui Lee, Benjamin W. Schafer, Denis Wirtz, Dong-Hwee Kim   +5 more
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Recent advances in understanding plant nuclear envelope proteins involved in nuclear morphology [PDF]

Journal of Experimental Botany, 2015
The nuclear envelope (NE) is a fundamental structure of the nucleus and plays an important role in nuclear morphology through the strict regulation of NE protein function. Beyond its physical barrier function between nucleoplasm and cytoplasm, recent studies of the plant NE have provided novel insights into basic aspects of nuclear morphology as well ...
Tamura, Kentaro, Goto, Chieko, Hara-Nishimura, Ikuko   +2 more
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LMNA Determines Nuclear Morphology During Syncytialization of Human Trophoblast Stem Cells. [PDF]

Front Cell Dev Biol, 2022
Wang Y, Wu H, Jiang X, Jia L, Wang M, Rong Y, Chen S, Wang Y, Xiao Z, Liang X, Wang H.   +10 more
europepmc   +2 more sources

MATLAB-based Methods Allow Precise, High-Throughput Quantification of Nuclear Morphology and Texture in Tachycardiomyopathy. [PDF]

J Histochem Cytochem
Mayer MNS, Köhler LM, Paulus M, Iberl S, Heinrich M, Wagner S, Maier LS, Dietl A.   +7 more
europepmc   +2 more sources

Morphology of nuclear transcription [PDF]

Histochemistry and Cell Biology, 2016
Gene expression control is a fundamental determinant of cellular life with transcription being the most important step. The spatial nuclear arrangement of the transcription process driven by RNA polymerases II and III is nonrandomly organized in foci, which is believed to add another regulatory layer on gene expression control.
Weipoltshammer, Klara, Schöfer, Christian   +1 more
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Intratumoral nuclear morphologic heterogeneity in prostate cancer [PDF]

Urology, 1997
Tumor heterogeneity can be measured by quantifying variance of nuclear characteristics by image analysis. Heterogeneity of cell nuclear features correlated with increased local progression in prostate cancer. In the present study, the influence of tumor heterogeneity on prostate-specific antigen (PSA) recurrence after radical retropubic prostatectomy ...
Poel, H.G. van der, Oosterhof, G.O.N., Schaafsma, H.E., Debruyne, F.M.J., Schalken, J.A.   +4 more
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Periodicity of nuclear morphology in human fibroblasts [PDF]

Nucleus, 2015
Morphology of the cell nucleus has been used as a key indicator of disease state and prognosis, but typically without quantitative rigor. It is also not well understood how nuclear morphology varies with time across different genetic backgrounds in healthy cells.
Laura, Seaman, Walter, Meixner, John, Snyder, Indika, Rajapakse   +3 more
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Nuclear morphologies: their diversity and functional relevance [PDF]

Chromosoma, 2016
Studies of chromosome and genome biology often focus on condensed chromatin in the form of chromosomes and neglect the non-dividing cells. Even when interphase nuclei are considered, they are often then treated as interchangeable round objects. However, different cell types can have very different nuclear shapes, and these shapes have impacts on ...
Skinner, Benjamin M, Johnson, Emma EP
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Apoptotic nuclear morphological change without DNA fragmentation [PDF]

Current Biology, 1999
Apoptosis is characterized morphologically by condensation and fragmentation of nuclei and cells and biochemically by fragmentation of chromosomal DNA into nucleosomal units [1]. CAD, also known as CPAN or DFF-40, is a DNase that can be activated by caspases [2] [3] [4] [5] [6]. CAD is complexed with its inhibitor, ICAD, in growing, non-apoptotic cells
Sakahira, Hideki, Enari, Masato, Ohsawa, Yoshiyuki, Uchiyama, Yasuo, Nagata, Shigekazu   +4 more
openaire   +2 more sources