Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease
EMBO Molecular Medicine, 2020 Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence showing that increased lamin B1 levels contribute to the pathophysiology of Huntington’s disease (HD), a CAG repeat‐associated neurodegenerative disorder.
Rafael Alcalá‐Vida +14 more
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Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery [PDF]
, 2013 BACKGROUND: Different cell types have distinctive patterns of chromosome positioning in the nucleus. Although ectopic affinity-tethering of specific loci can be used to relocate chromosomes to the nuclear periphery, endogenous nuclear envelope proteins ...
Vassiliki Lazou +23 more
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Intratumoral nuclear morphologic heterogeneity in prostate cancer [PDF]
Urology, 1997 Tumor heterogeneity can be measured by quantifying variance of nuclear characteristics by image analysis. Heterogeneity of cell nuclear features correlated with increased local progression in prostate cancer. In the present study, the influence of tumor heterogeneity on prostate-specific antigen (PSA) recurrence after radical retropubic prostatectomy ...
Poel, H.G. van der +4 more
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Derivation of a nuclear heterogeneity image index to grade DCIS
Computational and Structural Biotechnology Journal, 2020 Abnormalities in cell nuclear morphology are a hallmark of cancer. Histological assessment of cell nuclear morphology is frequently used by pathologists to grade ductal carcinoma in situ (DCIS).
Mary-Kate Hayward +7 more
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Nuclear shape changes are induced by knockdown of the SWI/SNF ATPase BRG1 and are independent of cytoskeletal connections. [PDF]
PLoS ONE, 2013 Changes in nuclear morphology occur during normal development and have been observed during the progression of several diseases. The shape of a nucleus is governed by the balance of forces exerted by nuclear-cytoskeletal contacts and internal forces ...
Karen M Imbalzano +5 more
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Roots and Lexicality in Distributed Morphology [PDF]
, 2012 Fifth York-Essex Morphology Meeting (YEMM), 9th February and 10th February 2008, Department of Language and Linguistic Science, University of YorkThis paper examines the nature and content of morphological roots in relation to their syntactic context. A
Acquaviva, Paolo
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Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD
Acta Neuropathologica Communications, 2021 The most common genetic cause of familial and sporadic amyotrophic lateral sclerosis (ALS) is a GGGGCC hexanucleotide repeat expansion (HRE) in the C9orf72 gene.
Alyssa N. Coyne, Jeffrey D. Rothstein
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Role of LINC proteins in plant nuclear morphology [PDF]
Plant Signaling & Behavior, 2008 A common fate of post-mitotic interphase plant nuclei is morphological differentiation into an array of shapes and sizes. Development of nuclear morphology occurs in a cell-specific manner and is influenced by cell shape and nuclear DNA content. The LINC (LITTLE NUCLEI) proteins are plant-specific nuclear coiled-coil proteins that appear to couple ...
Travis A, Dittmer, Eric J, Richards
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Reducing CO2 emissions : nuclear and the alternatives [PDF]
, 2012 This paper is the second in a series of 8 that make up the evidence base for SDC report 'The role of nuclear power in a low carbon economy'.Publisher ...
Sustainable Development Commission
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Mechanical force alters morphogenetic movements and segmental gene expression patterns during Drosophila embryogenesis. [PDF]
PLoS ONE, 2012 The development of an organism is accompanied by various cellular morphogenetic movements, changes in cellular as well as nuclear morphology and transcription programs.
Abhishek Kumar, G V Shivashankar
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