Results 41 to 50 of about 809,360 (285)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The Novel Nuclear Envelope Protein KAKU4 Modulates Nuclear Morphology inArabidopsis  [PDF]

The Plant Cell, 2014
AbstractIn animals, the nuclear lamina is a fibrillar meshwork on the inner surface of the nuclear envelope, composed of coiled-coil lamin proteins and lamin binding membrane proteins. Plants also have a meshwork on the inner surface of the nuclear envelope, but little is known about its composition other than the presence of members of the CROWDED ...
Chieko, Goto, Kentaro, Tamura, Yoichiro, Fukao, Tomoo, Shimada, Ikuko, Hara-Nishimura   +4 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

High-resolution X-ray spectroscopy and imaging of the nuclear outflow of the starburst galaxy NGC 253 [PDF]

, 2006
Aims: Using XMM-Newton data, we have aimed to study the nuclear outflow of the nearby starburst galaxy NGC 253 in X-rays with respect to its morphology and to spectral variations along the outflow.
A. Read, Behar, Breitschwerdt, Colina, D. Breitschwerdt, de Avillez, de Avillez, den Herder, Doron, Fabbiano, Forbes, G. Trinchieri, Jansen, Koribalski, Kosenko, M. Bauer, M. Ehle, Mewe, Phillips, Pietsch, Pietsch, Porquet, Puche, Read, Rugge, Stevens, Strickland, Strickland, Strüder, Tanaka, Turner, van der Heyden, Veilleux, W. Pietsch   +33 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

No More Active Galactic Nuclei in Clumpy Disks Than in Smooth Galaxies at z~2 in CANDELS / 3D-HST [PDF]

, 2014
We use CANDELS imaging, 3D-HST spectroscopy, and Chandra X-ray data to investigate if active galactic nuclei (AGNs) are preferentially fueled by violent disk instabilities funneling gas into galaxy centers at 1 ...
Barro, Guillermo, Bell, Eric F., Brammer, Gabriel B., Brandt, W. Niel, Dekel, Avishai, Faber, S. M., Ferguson, Henry C., Grogin, Norman A., Guo, Yicheng, Hopkins, Philip F., Juneau, Stephanie, Kartaltepe, Jeyhan, Kocevski, Dale D., Koekemoer, Anton M., Koo, David C., Lotz, Jennifer, Luo, Bin, Maseda, Michael, McIntosh, Daniel H., Momcheva, Ivelina, Mozena, Mark, Nandra, Kirpal, Rosario, David J., Trump, Jonathan R., Weiner, Benjamin J., Zeimann, Gregory R.   +25 more
core   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Automated segmentation of tissue images for computerized IHC analysis [PDF]

, 2010
This paper presents two automated methods for the segmentation ofimmunohistochemical tissue images that overcome the limitations of themanual approach aswell as of the existing computerized techniques.
A. Acquaviva, Borad, Boykov, Brey, Cheng, Cheng, Cregger, Cualing, Di Cataldo, Divito, E. Ficarra, E. Macii, Ficarra, Ficarra, Fuchs, Gonzalez, Gudla, Huang, Jacob, Jain, Kim, Lacroix-Triki, Landini, Long, Lopez, Luck, Markiewicz, Masmoudi, Matula, Mukherjee, Naik, Pinidiyaarachchi, Ruifrok, Ruifrok, S. Di Cataldo, Statnikov, Taneja, Theodosiou, Twellmann, Wang, Wolff, Yang, Zehntner, Zhang   +43 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Density Waves Inside Inner Lindblad Resonance: Nuclear Spirals in Disk Galaxies [PDF]

, 1999
We analyze formation of grand-design two-arm spiral structure in the nuclear regions of disk galaxies. Such morphology has been recently detected in a number of objects using high-resolution near-infrared observations.
Athanassoula E., Buta R., Contopoulos G., Englmaier P., Ferrers N. M., Isaac Shlosman, Mulder W. A., Peter Englmaier, Schwarz M. P., van Albada T. S.   +9 more
core   +2 more sources