Results 61 to 70 of about 809,360 (285)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The 1.6 micron near infrared nuclei of 3C radio galaxies: Jets, thermal emission or scattered light?

, 2010
Using HST NICMOS 2 observations we have measured 1.6-micron near infrared nuclear luminosities of 100 3CR radio galaxies with ...
Akritas, Akujor, Alessandro Capetti, Alice C. Quillen, Baggett, Bennett, Bennett, Black, Caon, Capaccioli, Chakravarti, Chiaberge, Chiaberge, Chiaberge, Chiaberge, Christopher P. O’Dea, Cleary, Das, David J. Axon, de Koff, Dicken, Donzelli, Ekers, F. Duccio Macchetto, Fanaroff, Ferrarese, Floyd, Ghisellini, Giovannini, Giovannini, Haas, Hardcastle, Hine, Hine, Hurt, Jackson, Jedrzejewski, Jones, Kendall, Kharb, Kovalev, Laing, Landt, Lavalley, Lawrence, Leipski, Madrid, Marco Chiaberge, Morganti, Netzer, Ogle, Okuda, Osterbrock, Owen, Peng, Perlman, Ranieri D. Baldi, Rawlings, Riley, Sersic, Shi, Smolčić, Spencer, Stefi A. Baum, Trujillo, Tsvetanov, van Breugel, Venturi, Verdoes Kleijn, Vermeulen, Waggett, Walker, Wall, Whysong, William Sparks, Xu, Xu, Zirbel   +77 more
core   +1 more source

Optical off-nuclear spectra of quasar hosts and radio galaxies [PDF]

, 2000
We present optical (~3200A to ~9000A) off-nuclear spectra of 26 powerful active galaxies in the redshift range 0.1 < z < 0.3, obtained with the Mayall and William Herschel 4-meter class telescopes.
Boroson, Todd, Dunlop, James S., Hughes, David H., Kukula, Marek J.   +3 more
core   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Transformation of nuclear morphology during cellular maturation. [PDF]

Journal of Histochemistry & Cytochemistry, 1979
Using in vivo labeling of mouse leukocytes with tritiated thymidine, cells in the neutrophilic series were studied to determine the change in their nuclear shape as a function of maturation level. Several morphologic shape parameters including perimeter and bending energy were used to quantify the distribution of the nuclear morphology in a given age ...
J M, Teich, I T, Young, S E, Sher, J S, Lee   +3 more
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Effects of an AGN on Host Galaxy Colour and Morphology Measurements

, 2010
We assess the effects of simulated active galactic nuclei (AGNs) on the colour and morphology measurements of their host galaxies. To test the morphology measurements, we select a sample of galaxies not known to host AGNs and add a series of point ...
A. L. Coil, A. M. Koekemoer, Abraham, Barden, Bell, Bennert, Bertin, Blanton, C. J. Conselice, C. M. Pierce, Ciotti, Coil, Conselice, Conselice, Conselice, Croton, D. C. Koo, D. J. V. Rosario, Davis, de Bruyn, E. S. Laird, Francis, Gabor, Georgakakis, Gini, Griffith, Grogin, Grogin, Hopkins, Hopkins, Hopkins, Hopkins, Häussler, Ivison, J. M. Lotz, J. R. Primack, Kauffmann, Kauffmann, Kennicutt, Kennicutt, Kim, Kinney, Laird, Lotz, Lotz, Lotz, Nandra, Peng, Petrosian, Pierce, Pierce, R. J. Ivison, R. L. Griffith, R. Yan, S. M. Faber, S. Salim, Schawinski, Silverman, Simmons, Somerville, Sánchez, Trujillo, Urrutia, Weiner, Willmer, Wyder   +65 more
core   +1 more source