Results 81 to 90 of about 809,360 (285)
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Nuclear morphology measurements using Fourier domain low-coherence interferometry
SPIE Proceedings, 2005 We present a new common path configuration Fourier domain low coherence interferometry (fLCI) optical system and demonstrate its capabilities by presenting results which determine the size of cell nuclei in a monolayer of T84 epithelial cells. The optical system uses a white light source in a modified Michelson interferometer and a spectrograph for ...
Robert N, Graf, Adam, Wax
openaire +2 more sources
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Figure S6 from FLYWCH1, a Novel Suppressor of Nuclear β-Catenin, Regulates Migration and Morphology in Colorectal Cancer [PDF]
, 2023 Belal A. Muhammad +10 more
openalex +2 more sources
ALMA reveals the feeding of the Seyfert 1 nucleus in NGC 1566
, 2014 We report ALMA observations of CO(3-2) emission in the Seyfert 1 galaxy NGC 1566, at a spatial resolution of 25 pc. Our aim is to investigate the morphology and dynamics of the gas inside the central kpc, and to probe nuclear fueling and feedback ...
Baker, A. J. +11 more
core +3 more sources
Hydrodynamic Simulations for the Nuclear Morphology of NGC 4314 [PDF]
, 2001 H. B. Ann
openalex +1 more source
The inner nuclear membrane protein Lem2 is critical for normal nuclear envelope morphology
FEBS Letters, 2006 The inner nuclear membrane (INM) of eukaryotic cells is characterized by a unique set of transmembrane proteins which interact with chromatin and/or the nuclear lamina. The number of identified INM proteins is steadily increasing, mainly as a result of proteomic and computational approaches.
Ulbert, Sebastian +3 more
openaire +2 more sources