Nuclear membrane protein Lem2 regulates nuclear size through membrane flow [PDF]
Nature Communications, 2019 Nuclear size scales with cell size, but the underlying mechanisms are unclear. Here, the authors report in fission yeast that the inner nuclear membrane protein Lem2 and the ER membrane protein Lnp1 are barriers to membrane flow and propose that they ...
Kazunori Kume +3 more
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Unravelling nuclear size control. [PDF]
Curr Genet, 2019 Correlation between nuclear and cell size, the nucleocytoplasmic ratio, is a cellular phenomenon that has been reported throughout eukaryotes for more than a century but the mechanisms that achieve it are not well understood. Here, we review work that has shed light on the cellular processes involved in nuclear size control.
Cantwell H, Nurse P.
europepmc +9 more sources
Nuclear size rectification: A potential new therapeutic approach to reduce metastasis in cancer [PDF]
Frontiers in Cell and Developmental Biology, 2022 Research on metastasis has recently regained considerable interest with the hope that single cell technologies might reveal the most critical changes that support tumor spread.
Eric C. Schirmer +3 more
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Specificity of Nuclear Size Scaling in Frog Erythrocytes [PDF]
Frontiers in Cell and Developmental Biology, 2022 In eukaryotes, the cell has the ability to modulate the size of the nucleus depending on the surrounding environment, to enable nuclear functions such as DNA replication and transcription.
Tetsufumi Niide +3 more
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Reduction in Nuclear Size by DHRS7 in Prostate Cancer Cells and by Estradiol Propionate in DHRS7-Depleted Cells [PDF]
Cells, 2023 Increased nuclear size correlates with lower survival rates and higher grades for prostate cancer. The short-chain dehydrogenase/reductase (SDR) family member DHRS7 was suggested as a biomarker for use in prostate cancer grading because it is largely ...
Andrea Rizzotto +9 more
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Control of nuclear size by osmotic forces in Schizosaccharomyces pombe [PDF]
eLife, 2022 The size of the nucleus scales robustly with cell size so that the nuclear-to-cell volume ratio (N/C ratio) is maintained during cell growth in many cell types. The mechanism responsible for this scaling remains mysterious.
Joël Lemière +4 more
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Identification of epigenetic modulators as determinants of nuclear size and shape [PDF]
eLife, 2023 The shape and size of the human cell nucleus is highly variable among cell types and tissues. Changes in nuclear morphology are associated with disease, including cancer, as well as with premature and normal aging.
Andria C Schibler +4 more
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EPJ Web of Conferences, 2016 Developing of methods of measuring the radii of nuclei in their highly excited states led to observation of those with dimensions enhanced and, probably, diminished in comparison with the corresponding ground states.
Ogloblin Alexey +5 more
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Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation [PDF]
Cell Death Discovery, 2023 The mechanism of nuclear size determination and alteration during normal lineage development and cancer pathologies which is not fully understood. As recently reported, chromatin modification can change nuclear morphology.
Lingjun Meng
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SUN1/2 controls macrophage polarization via modulating nuclear size and stiffness [PDF]
Nature Communications, 2023 Alteration of the size and stiffness of the nucleus triggered by environmental cues are thought to be important for eukaryotic cell fate and function.
Shi Jiao +10 more
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