Nuclear Size Control in Fission Yeast [PDF]
Journal of Cell Biology, 2007 A long-standing biological question is how a eukaryotic cell controls the size of its nucleus. We report here that in fission yeast, nuclear size is proportional to cell size over a 35-fold range, and use mutants to show that a 16-fold change in nuclear DNA content does not influence the relative size of the nucleus. Multi-nucleated cells with unevenly
Frank R Neumann, Paul Nurse
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A systematic genetic screen identifies essential factors involved in nuclear size control. [PDF]
PLoS Genetics, 2019 Nuclear size correlates with cell size, but the mechanism by which this scaling is achieved is not known. Here we screen fission yeast gene deletion mutants to identify essential factors involved in this process.
Helena Cantwell, Paul Nurse
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Elucidating nuclear size control in the Xenopus model system [PDF]
Veterinarski Glasnik, 2018 Background. Nuclear size is a tightly regulated cellular feature. Mechanisms that regulate nuclear size and the functional significance of this regulation are largely unknown. Nuclear size and morphology are often altered in many diseases, such as cancer.
Jevtić Predrag, Levy Daniel L.
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Evaluation of the relation between Lens Opacities Classification System III grading and nuclear size by direct measurement [PDF]
Taiwan Journal of Ophthalmology, 2020 CONTEXT: Although relation between Lens Opacities Classification System III (LOCS III) and nuclear density is established, no data are available about nuclear size at different LOCS III grades.
Chidanand Kulkarni
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Cancer-associated SPOP mutations enlarge nuclear size and facilitate nuclear envelope rupture upon farnesyltransferase inhibitor treatment [PDF]
The Journal of Clinical InvestigationNuclear size is crucial for cellular functions and often increases with malignancy. Irregular nuclei are linked to aggressive tumors, driven by genetic and epigenetic changes.
Zixi Wang +14 more
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A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control. [PDF]
PLoS Genetics, 2017 How cells control the overall size and growth of membrane-bound organelles is an important unanswered question of cell biology. Fission yeast cells maintain a nuclear size proportional to cellular size, resulting in a constant ratio between nuclear and ...
Kazunori Kume +5 more
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Tumour nuclear size heterogeneity as a biomarker for post-radiotherapy outcomes in gynecological malignancies [PDF]
Physics and Imaging in Radiation OncologyBackground and Purpose:: Radiotherapy targets DNA in cancer cell nuclei. Radiation dose, however, is prescribed to a macroscopic target volume assuming uniform distribution, failing to consider microscopic variations in dose absorbed by individual nuclei.
Yujing Zou +6 more
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Topology and Nuclear Size Determine Cell Packing on Growing Lung Spheroids [PDF]
Physical Review XWithin multicellular living systems, cells coordinate their positions with spatiotemporal accuracy to form various tissue structures and control development.
Wenhui Tang +7 more
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Nuclear Structure, Size Regulation, and Role in Cell Migration
CellsThe nucleus serves as a pivotal regulatory and control hub in the cell, governing numerous aspects of cellular functions, including DNA replication, transcription, and RNA processing.
Yuhao Li +5 more
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Size matters: three methods for estimating nuclear size in mycorrhizal roots of Medicago truncatula by image analysis [PDF]
BMC Plant Biology, 2019 Background The intracellular accommodation of arbuscular mycorrhizal (AM) fungi involves a profound molecular reprogramming of the host cell architecture and metabolism, based on the activation of a symbiotic signaling pathway.
Gennaro Carotenuto +4 more
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