Results 91 to 100 of about 2,793,192 (280)

Chromatin integrity, nuclear morphology and protamine content.

, 2022
A) Agarose gel of DNA extracted from WT, Prm2+/-, Prm2-/- and Prm2+/Δc mature sperm. B) Comparison of mature sperm nucleus consensus shapes of WT, Prm2+/-, Prm2-/-, Prm2+/Δc and Prm2-/Δc resulting from nuclear morphology analysis.
Lena Arévalo (8148903), Simon Schneider (749180), Isabelle Sophie Neumann (12969420), Hubert Schorle (15757), Gina Esther Merges (12969414), Franka Enow Oben (12969417)   +5 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Heterogeneous Nuclear Ribonucleoprotein A1 Knockdown Alters Constituents of Nucleocytoplasmic Transport

Brain Sciences
Background/Objectives: Changes in nuclear morphology, alterations to the nuclear pore complex (NPC), including loss, aggregation, and dysfunction of nucleoporins (Nups), and nucleocytoplasmic transport (NCT) abnormalities have become hallmarks of ...
Todd E. Stang, Hannah E. Salapa, Joseph-Patrick W. E. Clarke, Bogdan F. Popescu, Michael C. Levin   +4 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Nuclear Regulatory Commission Report NUREG-0084

, 1977
The proposed project: Pursuant to the Atomic Energy Act, as amended, the U.S. Nuclear Regulatory Commission's regulations in Title 10, Code of Federal Regulations, an application with an accompanying Environmental Report, was filed by Northeast Utilities
U.S. Nuclear Regulatory Commission. Office of Nuclear Reactor Regulation.
core  

NRC - regulator of nuclear safety

, 1997
The U.S. Nuclear Regulatory Commission (NRC) was formed in 1975 to regulate the various commercial and institutional uses of nuclear energy, including nuclear power plants.

core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Nuclear Tracks Morphology Study Using Raman Methodology [PDF]

, 2016
In this work, a new methodology for rendering profiles of etched nuclear tracks is presented, using confocal micro-Raman spectrometry instrumentation. The precise profile of etched nuclear tracks with normal and/or angular incidence of the particle can ...
Vazquez-Lopez, C., Rurik-Farias, J., Fragoso-Soriano, R., Golzarri, J. I., Azamar-Barrios, J. A., Cerda Z., Mariana, Zendejas-Leal, B. E., Espinosa, G.   +7 more
core   +1 more source

Correction: Uccelli, L., et al. Therapeutic Radiometals: Worldwide Scientific Literature Trend Analysis (2008–2018). Molecules 2019, 24, 640

Molecules, 2019
The authors wish to make the following corrections to their paper [...]
Licia Uccelli, Petra Martini, Corrado Cittanti, Aldo Carnevale, Loretta Missiroli, Melchiore Giganti, Mirco Bartolomei, Alessandra Boschi   +7 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source