FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
The Morphology of Hadronic Emission Models for the Gamma-Ray Source at the Galactic Center
, 2012 Recently, detections of a high-energy gamma-ray source at the position of the Galactic center have been reported by multiple gamma-ray telescopes, spanning the energy range between 100 MeV and 100 TeV.
Linden, Tim +2 more
core +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Big bang simulation in superfluid 3He-B -- Vortex nucleation in neutron-irradiated superflow
, 1995 We report the observation of vortex formation upon the absorption of a thermal neutron in a rotating container of superfluid $^3$He-B. The nuclear reaction n + $^3$He = p + $^3$H + 0.76MeV heats a cigar shaped region of the superfluid into the normal ...
A Vilenkin +22 more
core +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
MP35-02 COMPUTER-EXTRACTED FEATURES OF NUCLEAR AND GLANDULAR MORPHOLOGY FROM DIGITAL H&E TISSUE IMAGES PREDICT PROSTATE CANCER BIOCHEMICAL RECURRENCE AND METASTASIS FOLLOWING RADICAL PROSTATECTOMY [PDF]
, 2018 Patrick Leo +6 more
openalex +1 more source
1413 From force to fate: LINCing cell junctions to nuclear morphology [PDF]
, 2023 A. Banerjee +6 more
openalex +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Automated Nuclear Lamina Network Recognition and Quantitative Analysis in Structured Illumination Super-Resolution Microscope Images Using a Gaussian Mixture Model and Morphological Processing [PDF]
, 2020 Yiwei Chen +8 more
openalex +1 more source