Results 71 to 80 of about 809,360 (285)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

The Consistency of Fermi-LAT Observations of the Galactic Center with a Millisecond Pulsar Population in the Central Stellar Cluster

, 2011
I show that the spectrum and morphology of a recent Fermi-LAT observation of the Galaxy center are consistent with a millisecond pulsar population in the nuclear Central stellar cluster of the Milky Way. The Galaxy Center gamma-ray spectrum is consistent
D. Haggard, D. Hooper, E. Ferrara, Fermi LAT collaboration, Fermi-LAT collaboration, Ferrmi-LAT collaboration, G. Meylan, Kevork N Abazajian, M.P. Muno .   +8 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

A Close Nuclear Black Hole Pair in the Spiral Galaxy NGC 3393

, 2011
The current picture of galaxy evolution advocates co-evolution of galaxies and their nuclear massive black holes (MBHs), through accretion and merging. Quasar pairs (6,000-300,000 light-years separation) exemplify the first stages of this gravitational ...
AI Diaz, AJ Cooke, C Rodriguez, F Civano, G Cusumano, G Fabbiano, G Risaliti, G. Fabbiano, G. Risaliti, GT Miyazawa, HR Schmitt, IM George, J Magorrian, JB Hutchings, Junfeng Wang, L Mayer, M Colpi, M Elvis, M Guainazzi, M. Elvis, MJ Valtonen, NA Levenson, P Gandhi, P Magdziarz, P Palmeri, PJ Green, PT Kondratko, R Cid Fernandes, R Maiolino, S Komossa, Simone Callegari, TA Boroson, TE Strohmayer, Y Fukazawa   +33 more
core   +1 more source

Figure S3 from FLYWCH1, a Novel Suppressor of Nuclear β-Catenin, Regulates Migration and Morphology in Colorectal Cancer [PDF]

, 2023
Belal A. Muhammad, Sheema Almozyan, Roya Babaei‐Jadidi, Emenike K. Onyido, Anas Saadeddin, Seyed Hossein Kashfi, Bradley Spencer‐Dene, Mohammad Ilyas, Anbarasu Lourdusamy, Axel Behrens, Abdolrahman S. Nateri   +10 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Nuclear DNA contents, rDNAs, and karyotype evolution in subgenus Vicia: III. The heterogeneous section Hypechusa. [PDF]

, 2006
: Nuclear DNA contents, automated karyotype analyses, and sequences of internal transcribed spacers from ribosomal genes have been determined in the species belonging to section Hypechusa of the sub-genus Vicia.
AMBROSIO M, CAPUTO, PAOLO, CREMONINI R., FREDIANI M, RAVALLI C, VENORA G   +5 more
core  

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Nuclear morphology in the nutritive cells ofDrosophila testes

Experientia, 1971
Peer ...
Stockert, Juan Carlos, Esponda, Pedro
openaire   +3 more sources