Cells, 2020 Nuclear shape modulates cell behavior and function, while aberrant nuclear morphologies correlate with pathological phenotype severity. Nevertheless, functions of specific nuclear morphological features and underlying molecular mechanisms remain poorly ...
Sebastian Martewicz +9 more
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Cellular and nuclear morphology…and calcium signaling: revealing the interplay between structure and function [PDF]
, 2012 Poster presentation: Calcium plays a pivotal role in relaying electrical signals of the cell to subcellular compartments, such as the nucleus. Since this one ion type is used by the cell for many processes a neuron needs to establish finely tuned calcium
Queisser, Sean Gillian +14 more
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Deformation of the nucleus by TGFβ1 via the remodeling of nuclear envelope and histone isoforms
Epigenetics & Chromatin, 2022 The cause of nuclear shape abnormalities which are often seen in pre-neoplastic and malignant tissues is not clear. In this study we report that deformation of the nucleus can be induced by TGFβ1 stimulation in several cell lines including Huh7.
Ya-Hui Chi +5 more
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Achieving the Way for Automated Segmentation of Nuclei in Cancer Tissue Images through Morphology-Based Approach: a Quantitative Evaluation [PDF]
, 2010 In this paper we address the problem of nuclear segmentation in cancer tissue images, that is critical for specific protein activity quantification and for cancer diagnosis and therapy.
MACII E. +4 more
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Defective Nuclear Lamina in Aneuploidy and Carcinogenesis
Frontiers in Oncology, 2018 Aneuploidy, loss or gain of whole chromosomes, is a prominent feature of carcinomas, and is generally considered to play an important role in the initiation and progression of cancer.
Elizabeth R. Smith +3 more
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Tuning between Nuclear Organization and Functionality in Health and Disease
Cells, 2023 The organization of eukaryotic genome in the nucleus, a double-membraned organelle separated from the cytoplasm, is highly complex and dynamic. The functional architecture of the nucleus is confined by the layers of internal and cytoplasmic elements ...
Naresh Kumar Manda +11 more
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Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease
EMBO Molecular Medicine, 2020 Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence showing that increased lamin B1 levels contribute to the pathophysiology of Huntington’s disease (HD), a CAG repeat‐associated neurodegenerative disorder.
Rafael Alcalá‐Vida +14 more
doaj +1 more source
Cohesiveness tunes assembly and morphology of FG nucleoporin domain meshworks – Implications for nuclear pore permeability [PDF]
, 2013 Nuclear pore complexes control the exchange of macromolecules between the cytoplasm and the nucleus. A selective permeability barrier that arises from a supramolecular assembly of intrinsically unfolded nucleoporin domains rich in phenylalanine-glycine ...
Frey, S. +16 more
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Economics of nuclear power [PDF]
, 2012 This paper is the fourth in a series of 8 that make up the evidence base for SDC report 'The role of nuclear power in a low carbon economy'.Publisher ...
Science and Technology Policy Research, University of Sussex +1 more
core +2 more sources
Derivation of a nuclear heterogeneity image index to grade DCIS
Computational and Structural Biotechnology Journal, 2020 Abnormalities in cell nuclear morphology are a hallmark of cancer. Histological assessment of cell nuclear morphology is frequently used by pathologists to grade ductal carcinoma in situ (DCIS).
Mary-Kate Hayward +7 more
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