Results 21 to 30 of about 446,559 (292)

Negative correlation between the nuclear size and nuclear Lamina component Lamin A in intraductal papillary mucinous neoplasms of the pancreas

Pathology and Oncology Research, 2022
Background: The nuclear laminar protein Lamin A and inner nuclear membrane protein Emerin plays important role in sustaining nuclear structure. However, They have not investigated the significance of these proteins for development of pancreatic ...
Tamaki Hiroe, Shunichi Moriya, Sayaka Kobayashi, Yoshimi Nishijima, Akira Watanabe, Ken Shirabe, Hayato Ikota, Hideaki Yokoo, Masanao Saio   +8 more
doaj   +1 more source

Phytochemical Analysis and In Vitro Cytotoxic Activity against Colorectal Adenocarcinoma Cells of Hippophae rhamnodies L., Cymbopogon citratus (D.C.) Stapf, and Ocimum basilicum L. Essential Oils

Plants, 2021
Colorectal carcinoma (CRC) is one of the most frequently diagnosed cancer types with current deficient and aggressive treatment options, but various studied alternative therapies are able to efficiently contribute to its management.
Alina Dolghi, Roxana Buzatu, Amadeus Dobrescu, Flavius Olaru, Grigore Alexandru Popescu, Iasmina Marcovici, Iulia Pinzaru, Dan Navolan, Octavian Marius Cretu, Iuliana Popescu, Cristina Adriana Dehelean   +10 more
doaj   +1 more source

Fluorescently labeled nuclear morphology is highly informative of neurotoxicity. [PDF]

Front Toxicol, 2022
Neurotoxicity can be detected in live microscopy by morphological changes such as retraction of neurites, fragmentation, blebbing of the neuronal soma and ultimately the disappearance of fluorescently labeled neurons.
Wang S, Linsley JW, Linsley DA, Lamstein J, Finkbeiner S.   +4 more
europepmc   +3 more sources

Morphology of nuclear transcription [PDF]

Histochemistry and Cell Biology, 2016
Gene expression control is a fundamental determinant of cellular life with transcription being the most important step. The spatial nuclear arrangement of the transcription process driven by RNA polymerases II and III is nonrandomly organized in foci, which is believed to add another regulatory layer on gene expression control.
Weipoltshammer, Klara, Schöfer, Christian   +1 more
openaire   +2 more sources

Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients

Frontiers in Cell and Developmental Biology, 2023
Primary fibroblasts from patient’s skin biopsies are directly isolated without any alteration in the genome, retaining in culture conditions their endogenous cellular characteristics and biochemical properties.
Saja Gharaba, Omri Paz, Lea Feld, Anastasia Abashidze, Maydan Weinrab, Noam Muchtar, Adam Baransi, Aviv Shalem, Aviv Shalem, Aviv Shalem, Uri Sprecher, Lior Wolf, Haguy Wolfenson, Miguel Weil   +13 more
doaj   +1 more source

Nuclear mechanosignaling in striated muscle diseases

Frontiers in Physiology, 2023
Mechanosignaling describes processes by which biomechanical stimuli are transduced into cellular responses. External biophysical forces can be transmitted via structural protein networks that span from the cellular membrane to the cytoskeleton and the ...
Bo Zhang, Joseph D. Powers, Andrew D. McCulloch, Andrew D. McCulloch, Neil C. Chi, Neil C. Chi, Neil C. Chi, Neil C. Chi   +7 more
doaj   +1 more source

Chromatin integrity, nuclear morphology and protamine content. [PDF]

, 2022
A) Agarose gel of DNA extracted from WT, Prm2+/-, Prm2-/- and Prm2+/Δc mature sperm. B) Comparison of mature sperm nucleus consensus shapes of WT, Prm2+/-, Prm2-/-, Prm2+/Δc and Prm2-/Δc resulting from nuclear morphology analysis.
Lena Arévalo (8148903), Simon Schneider (749180), Isabelle Sophie Neumann (12969420), Hubert Schorle (15757), Gina Esther Merges (12969414), Franka Enow Oben (12969417)   +5 more
core   +1 more source

Nuclear Dynamics and Chromatin Structure: Implications for Pancreatic Cancer

Cells, 2021
Changes in nuclear shape have been extensively associated with the dynamics and functionality of cancer cells. In most normal cells, nuclei have a regular ellipsoid shape and minimal variation in nuclear size; however, an irregular nuclear contour and ...
Luis F. Flores, Brooke R. Tader, Ezequiel J. Tolosa, Ashley N. Sigafoos, David L. Marks, Martin E. Fernandez-Zapico   +5 more
doaj   +1 more source

Current Methods and Pipelines for Image-Based Quantitation of Nuclear Shape and Nuclear Envelope Abnormalities

Cells, 2022
Any given cell type has an associated “normal” nuclear morphology, which is important to maintain proper cellular functioning and safeguard genomic integrity.
Anne F. J. Janssen, Sophia Y. Breusegem, Delphine Larrieu   +2 more
doaj   +1 more source

Periodicity of nuclear morphology in human fibroblasts [PDF]

Nucleus, 2015
Morphology of the cell nucleus has been used as a key indicator of disease state and prognosis, but typically without quantitative rigor. It is also not well understood how nuclear morphology varies with time across different genetic backgrounds in healthy cells.
Laura, Seaman, Walter, Meixner, John, Snyder, Indika, Rajapakse   +3 more
openaire   +2 more sources