Cell Reports, 2013 The nuclear lamina is a protein meshwork that lies under the inner nuclear membrane of metazoan cells. One function of the nuclear lamina is to organize heterochromatin at the inner nuclear periphery.
Andrey Poleshko +5 more
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Tyrosine phosphorylation of lamin A by Src promotes disassembly of nuclear lamina in interphase
Life Science Alliance, 2021 Phosphorylation of lamin A at tyrosine residue 45 by Src has an adverse effect on the assembly of nuclear lamina, which may be involved in nuclear dysmorphia, genomic instability, and nuclear plasticity in interphase.
Ching-Tung Chu +3 more
doaj +1 more source
A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence [PDF]
, 2008 The peripheral nuclear lamina, which is largely but not entirely associated with inactive chromatin, is considered to be an important determinant of nuclear structure and gene expression.
Kumaran, R. I., Spector, D. L.
core +1 more source
Pushing the (nuclear) envelope into meiosis. [PDF]
, 2013 A recent study shows that a short isoform of a mammalian nuclear lamin is important for homologous chromosome interactions during meiotic prophase in ...
Dernburg, Abby F
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The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence [PDF]
, 2016 AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression.
Astrologo, Letizia +14 more
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Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing [PDF]
, 2016 The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome.
Aznauryan, Erik +9 more
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Deformation of the nucleus by TGFβ1 via the remodeling of nuclear envelope and histone isoforms
Epigenetics & Chromatin, 2022 The cause of nuclear shape abnormalities which are often seen in pre-neoplastic and malignant tissues is not clear. In this study we report that deformation of the nucleus can be induced by TGFβ1 stimulation in several cell lines including Huh7.
Ya-Hui Chi +5 more
doaj +1 more source
Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis [PDF]
, 2004 Hutchinson-Gilford progeria syndrome is a rare genetic disorder that mimics certain aspects of aging prematurely. Recent work has revealed that mutations in the lamin A gene are a cause of the disease.
Bridger, JM, Kill, IR
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Baculovirus infection induces disruption of the nuclear lamina
Scientific Reports, 2017 Baculovirus nucleocapsids egress from the nucleus primarily via budding at the nuclear membrane. The nuclear lamina underlying the nuclear membrane represents a substantial barrier to nuclear egress. Whether the nuclear lamina undergoes disruption during
Xiaomei Zhang +5 more
doaj +1 more source
Genome–nuclear lamina interactions: from cell populations to single cells [PDF]
, 2017 Lamina-associated domains (LADs) are large genomic regions that interact with the nuclear lamina (NL) and help to guide the spatial folding of chromosomes in the interphase nucleus. LADs have been linked to gene repression and other functions.
Steensel, B. (Bas) van +1 more
core +4 more sources