Results 1 to 10 of about 7,574 (306)

The Pseudomonas aeruginosa reference strain PA14 displays increased virulence due to a mutation in ladS. [PDF]

PLoS ONE, 2011
Pseudomonas aeruginosa is a pathogen that causes acute and chronic infections in a variety of hosts. The pathogenic potential of P. aeruginosa is strain-dependent. PA14 is a highly virulent strain that causes disease in a wide range of organisms, whereas
Helga Mikkelsen, Rachel McMullan, Alain Filloux   +2 more
doaj   +4 more sources

Interplay of lamin A and lamin B LADs on the radial positioning of chromatin [PDF]

Nucleus, 2019
Immunosuppressive drugs such as cyclosporin A (CsA) can elicit hepatotoxicity by affecting gene expression. Here, we address the link between CsA and large-scale chromatin organization in HepG2 hepatocarcinoma cells.
Frida Forsberg, Annaël Brunet, Tharvesh M. Liyakat Ali, Philippe Collas   +3 more
doaj   +2 more sources

Peripheral chromatin remodeling at the center of zygotic genome activation [PDF]

Cell Genomics
Pal and colleagues1 investigate the molecular regulation of LAD establishment in mouse preimplantation embryos. This study provides insights into the physiological remodeling of LADs, revealing that zygotic LADs may be, in fact, dispensable during the ...
Laure de Chancel, Jean-Léon Maître
doaj   +2 more sources

LADS: a powerful vaccine platform for cancer immunotherapy and prevention

BMC Biology
Background The intracellular bacterium Listeria monocytogenes is an attractive vector for cancer immunotherapy as it can effectively deliver tumor antigens to antigen-presenting cells, leading to a robust antitumor response.
Houhui Song, Changyong Cheng, Xu Jiali   +2 more
exaly   +2 more sources

Major nuclear locales define nuclear genome organization and function beyond A and B compartments [PDF]

eLife
Models of nuclear genome organization often propose a binary division into active versus inactive compartments yet typically overlook nuclear bodies. Here, we integrated analysis of sequencing and image-based data to compare genome organization in four ...
Omid Gholamalamdari, Tom van Schaik, Yuchuan Wang, Pradeep Kumar, Liguo Zhang, Yang Zhang, Gabriela A Hernandez Gonzalez, Athanasios E Vouzas, Peiyao A Zhao, David M Gilbert, Jian Ma, Bas van Steensel, Andrew S Belmont   +12 more
doaj   +2 more sources

On Learning with LAD

CoRR, 2023
The logical analysis of data, LAD, is a technique that yields two-class classifiers based on Boolean functions having disjunctive normal form (DNF) representation. Although LAD algorithms employ optimization techniques, the resulting binary classifiers or binary rules do not lead to overfitting. We propose a theoretical justification for the absence of
C. A. Jothishwaran, Biplav Srivastava, Jitin Singla, Sugata Gangopadhyay   +3 more
openaire   +2 more sources

Restructuring of Lamina-Associated Domains in Senescence and Cancer

Cells, 2022
Induction of cellular senescence or cancer is associated with a reshaping of the nuclear envelope and a broad reorganization of heterochromatin. At the periphery of mammalian nuclei, heterochromatin is stabilized at the nuclear lamina via lamina ...
Aurélie Bellanger, Julia Madsen-Østerbye, Natalia M. Galigniana, Philippe Collas   +3 more
doaj   +1 more source

Local euchromatin enrichment in lamina-associated domains anticipates their repositioning in the adipogenic lineage

Genome Biology, 2022
Background Interactions of chromatin with the nuclear lamina via lamina-associated domains (LADs) confer structural stability to the genome. The dynamics of positioning of LADs during differentiation, and how LADs impinge on developmental gene expression,
Julia Madsen-Østerbye, Mohamed Abdelhalim, Marie-Odile Baudement, Philippe Collas   +3 more
doaj   +1 more source

Generating LADs that Make Sense [PDF]

, 2023
International audienceLearning Analytics Dashboards (LADs) deliver rich and actionable representations of learning data to support meaningful and insightful decisions that ultimately leverage the learning process.
Sadallah, Madjid, Gilliot, Jean-Marie
core   +1 more source

Facilitating the Use of Data From Multiple Sources for Formative Learning in the Context of Digital Assessments: Informing the Design and Development of Learning Analytic Dashboards

Frontiers in Education, 2022
Learning analytic dashboards (LADs) are data visualization systems that use dynamic data in digital learning environments to provide students, teachers, and administrators with a wealth of information about student’s engagement, experiences, and ...
Priya Kannan, Diego Zapata-Rivera
doaj   +1 more source