Results 11 to 20 of about 5,367 (216)

The relative abundance of languages: Neutral and non-neutral dynamics.

PLoS ONE, 2021
Credible estimates suggest that a large number of the nearly 7000 languages in the world could go extinct this century, a prospect with profound cultural, socioeconomic, and political ramifications. Despite its importance, we still have little predictive
Luís Borda-de-Água, Stephen P Hubbell
doaj   +1 more source

Transcription start site‐level expression of thyroid transcription factor 1 isoforms in lung adenocarcinoma and its clinicopathological significance

The Journal of Pathology: Clinical Research, 2021
There are multiple transcription start sites (TSSs) in agreement with multiple transcript variants encoding different isoforms of NKX2‐1/TTF‐1 (thyroid transcription factor 1); however, the clinicopathological significance of each transcript isoform of ...
Kei Sano, Takuo Hayashi, Yoshiyuki Suehara, Masaki Hosoya, Kazuya Takamochi, Shinji Kohsaka, Satsuki Kishikawa, Monami Kishi, Satomi Saito, Fumiyuki Takahashi, Kazuo Kaneko, Kenji Suzuki, Takashi Yao, Muneaki Ishijima, Tsuyoshi Saito   +14 more
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The Hybrid Histidine Kinase LadS Forms a Multicomponent Signal Transduction System with the GacS/GacA Two-Component System in Pseudomonas aeruginosa.

PLoS Genetics, 2016
In response to environmental changes, Pseudomonas aeruginosa is able to switch from a planktonic (free swimming) to a sessile (biofilm) lifestyle. The two-component system (TCS) GacS/GacA activates the production of two small non-coding RNAs, RsmY and ...
Gaël Chambonnier, Lorène Roux, David Redelberger, Firas Fadel, Alain Filloux, Melissa Sivaneson, Sophie de Bentzmann, Christophe Bordi   +7 more
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Is there an association between left atrial outpouching structures and recurrence of atrial fibrillation after catheter ablation?

PLoS ONE, 2022
ObjectiveThe aim of this study was to investigate the impact of left atrial diverticula (LADs), left sided septal pouches (LSSPs) and middle right pulmonary veins (MRPVs) on recurrent atrial fibrillation (rAF) in patients undergoing laser pulmonary vein ...
Erkan Celik, Nils Große Hokamp, Lukas Goertz, Wolfgang Fehske, Dinh Quang Nguyen, Lutz Lichtenberg, Robert Peter Reimer, David Maintz, Christoph Düber, Tobias Achenbach   +9 more
doaj   +1 more source

Nuclear Lamin B1 Interactions With Chromatin During the Circadian Cycle Are Uncoupled From Periodic Gene Expression

Frontiers in Genetics, 2019
Many mammalian genes exhibit circadian expression patterns concordant with periodic binding of transcription factors, chromatin modifications, and chromosomal interactions. Here we investigate whether chromatin periodically associates with nuclear lamins.
Annaël Brunet, Frida Forsberg, Qiong Fan, Thomas Sæther, Philippe Collas, Philippe Collas   +5 more
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Strong interactions between highly dynamic lamina-associated domains and the nuclear envelope stabilize the 3D architecture of Drosophila interphase chromatin

Epigenetics & Chromatin, 2023
Background Interactions among topologically associating domains (TADs), and between the nuclear envelope (NE) and lamina-associated domains (LADs) are expected to shape various aspects of three-dimensional (3D) chromatin structure and dynamics; however ...
Igor S. Tolokh, Nicholas Allen Kinney, Igor V. Sharakhov, Alexey V. Onufriev   +3 more
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How Students Use Learning Analytics Dashboards in Higher Education: A Learning Performance Perspective

SAGE Open, 2023
Developed to maximize learning performance, learning analytics dashboards (LAD) are becoming increasingly commonplace in education. An LAD’s effectiveness depends on how it is used and varies according to users’ academic levels.
Li Chen, Xuewang Geng, Min Lu, Atsushi Shimada, Masanori Yamada   +4 more
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Interplay of lamin A and lamin B LADs on the radial positioning of chromatin

Nucleus, 2019
Immunosuppressive drugs such as cyclosporin A (CsA) can elicit hepatotoxicity by affecting gene expression. Here, we address the link between CsA and large-scale chromatin organization in HepG2 hepatocarcinoma cells.
Frida Forsberg, Annaël Brunet, Tharvesh M. Liyakat Ali, Philippe Collas   +3 more
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Cellular and Genomic Features of Muscle Differentiation from Isogenic Fibroblasts and Myoblasts

Cells, 2023
The ability to recapitulate muscle differentiation in vitro enables the exploration of mechanisms underlying myogenesis and muscle diseases. However, obtaining myoblasts from patients with neuromuscular diseases or from healthy subjects poses ethical and
Louise Benarroch, Julia Madsen-Østerbye, Mohamed Abdelhalim, Kamel Mamchaoui, Jessica Ohana, Anne Bigot, Vincent Mouly, Gisèle Bonne, Anne T. Bertrand, Philippe Collas   +9 more
doaj   +1 more source

Lamina Associated Domains and Gene Regulation in Development and Cancer

Cells, 2019
The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization.
Silke J. A. Lochs, Samy Kefalopoulou, Jop Kind   +2 more
doaj   +1 more source