Genetically reprogrammed BMSCs with Lamin B1 depletion enhance bone regeneration for osteoporosis therapy [PDF]
Frontiers in Bioengineering and BiotechnologyBackgroundMesenchymal stem cell (MSC) dysfunction contributes to impaired bone regeneration in osteoporosis. Lamin B1, a nuclear lamina protein implicated in stem cell aging, has an unclear role in osteogenesis.MethodsWe examined Lamin B1 expression ...
Xuekun Fu +13 more
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Inverse correlation between Lamin A/C and survival in ovarian cancer: implications for predicting responsiveness to taxane-based chemotherapy [PDF]
Gynecologic Oncology ReportsObjective: Although paclitaxel is widely used to treat several solid cancers, the initial response rate in ovarian cancer is ∼60 %, but only ∼30 % in recurrent ovarian cancer.
Elizabeth R. Smith +7 more
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Frontiers in Bioscience-Landmark, 2023 Background: Lamins are the major component of nuclear lamina. Alternative splicing of the 12 exons comprising lamin A/C gene creates five known transcript variants, lamin A, lamin C, lamin AΔ10, lamin AΔ50, and lamin C2. The main objective for this study
Lin Batha +6 more
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LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior
eLife, 2021 Lamins form stable filaments at the nuclear periphery in metazoans. Unlike B-type lamins, lamins A and C localize also in the nuclear interior, where they interact with lamin-associated polypeptide 2 alpha (LAP2α).
Nana Naetar +8 more
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Parameters optimization of heterojunction ZnSe/CdS/CIGS/Si solar cells using SCAPS-1D software
Revue des Énergies Renouvelables, 2022 It is required to simulate the performance of a photovoltaic solar cell performance to enhance it. Simulation optimization has the benefit of being inexpensive and straightforward, and it allows us to identify the optimum parameters that contribute to ...
Moussaab Belarbi +2 more
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Role of C-Terminal Phosphorylation of Lamin A in DNA Damage and Cellular Senescence
Cells, 2023 The nuclear matrix protein lamin A is a multifunctional protein with roles in DNA replication and repair, gene activation, transcriptional regulation, and maintenance of higher-order chromatin structure. Phosphorylation is the main determinant of lamin A
Ying Ao +7 more
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The Dynamics of Lamin a During the Cell Cycle
Frontiers in Molecular Biosciences, 2021 Lamin proteins play an essential role in maintaining the nuclear organization and integrity; and lamin A, in particular, plays a major role in the whole volume of the nuclear interior.
Anat Vivante +3 more
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Lamin A and Prelamin a Counteract Migration of Osteosarcoma Cells
Cells, 2020 A type lamins are fundamental components of the nuclear lamina. Changes in lamin A expression correlate with malignant transformation in several cancers. However, the role of lamin A has not been explored in osteosarcoma (OS).
Camilla Evangelisti +11 more
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Neddylation modification regulates lamin B1 expression in breast cancer [PDF]
Zhongguo aizheng zazhi, 2022 Background and purpose: The role of neddylation modification in breast cancer has rarely been reported. Previous study found that neddylation modification blocking induced cellular senescence in breast cancer, however, the potential mechanism has not yet
JIA Xiaoqing, SUN Xiaoyin, JIANG Beiqi, MEI Zhangyi, FU Yun, ZHUANG Zhigang
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Lamin C is required to establish genome organization after mitosis
Genome Biology, 2021 Background The dynamic 3D organization of the genome is central to gene regulation and development. The nuclear lamina influences genome organization through the tethering of lamina-associated domains (LADs) to the nuclear periphery.
Xianrong Wong +5 more
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