Results 1 to 10 of about 43,097 (243)

Antagonistic contributions of A-type and B-type lamins to LBR localization and dynamics [PDF]

Nucleus
Lamin B receptor (LBR) is an inner nuclear membrane protein that organizes peripheral heterochromatin and cooperates with lamins to tether chromatin at the nuclear periphery.
Jacob Odell, Kristen Nedza, Alexander Sopilniak-Mints, Jan Lammerding   +3 more
doaj   +2 more sources

Orientia tsutsugamushi targets lamin A using Ank effectors and alters chromatin to inhibit NF-κB [PDF]

Communications Biology
Nuclear factor-κB (NF-κB) nuclear localization and gene accessibility is mediated by Ser22-phosphorylated lamin A/C (pSer22-lamin A/C). Here, we report that the intracellular bacterium Orientia tsutsugamushi impairs NF-κB nuclear accumulation by ...
Thomas E. Siff, Paige E. Allen, Haley E. Adcox, Svetlana Blinova, Travis J. Chiarelli, Jason R. Hunt, Joseph Wang, David L. Armistead, John S. Billingsley, Nathaniel O’Bier, Christofer N. Perry, Kelsey N. O’Neill, Richard T. Marconi, Mikhail Dozmorov, Andrew K. Ottens, Jason A. Carlyon   +15 more
doaj   +2 more sources

Lamin B1 safeguards the B cell genome and shapes lymphoma outcome [PDF]

HemaSphere
Lamin B1 is a structural component of the nuclear lamina that participates in genome organization and transcriptional control. During adaptive immune responses, B lymphocytes in germinal centers (GCs) undergo clonal expansion and programmed DNA damage at
Filip Filipsky, Katarina B. Chapman, Johannes Bloehdorn, Oscar Maiques, Abigail Lee, Andrew Clear, Jun Wang, John Gribben, Michael Hausmann, Christoph Cremer, Andrejs Braun, Marta C. Sallan, Tanya Klymenko   +12 more
doaj   +2 more sources

Matrix stiffness induces midnolin-dependent lamin B1 degradation to control myoblast differentiation [PDF]

EMBO Reports
Cells decode mechanical cues to direct fate decisions through nuclear remodeling, yet nuclear adaptors to mechanical signals remain elusive. Here, we show that soft matrix suppresses myoblast differentiation and induces nuclear abnormality within 30 min,
Liping Guo, Yanjing Zhao, Zhe Zhang, Chang Sun, Yafan Xie, Qin Dai, Yan Yan, Yaoqi Zhou, Yang Zhang, Quhuan Li, Juhui Qiu, Qin Peng   +11 more
doaj   +2 more sources

Differential Gene Expression Signatures and Cellular Signaling Pathways induced by Lamin A/C Transcript Variants in MCF7 Cell Line

Frontiers in Bioscience-Landmark, 2023
Background: Lamins are the major component of nuclear lamina. Alternative splicing of the 12 exons comprising lamin A/C gene creates five known transcript variants, lamin A, lamin C, lamin AΔ10, lamin AΔ50, and lamin C2. The main objective for this study
Lin Batha, Mohammad Azhar Aziz, Mahmoud Zhra, Jasmine Holail, Wedad S. Al-Qahtani, Rajaa Fakhoury, Ahmad Aljada   +6 more
doaj   +1 more source

LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

eLife, 2021
Lamins form stable filaments at the nuclear periphery in metazoans. Unlike B-type lamins, lamins A and C localize also in the nuclear interior, where they interact with lamin-associated polypeptide 2 alpha (LAP2α).
Nana Naetar, Konstantina Georgiou, Christian Knapp, Irena Bronshtein, Elisabeth Zier, Petra Fichtinger, Thomas Dechat, Yuval Garini, Roland Foisner   +8 more
doaj   +1 more source

Lamins [PDF]

Current Biology, 2016
Xie and Burke discuss the roles of lamins in nuclear morphology and the pathological consequences of defects in these nuclear envelope proteins.
Wei, Xie, Brian, Burke
openaire   +2 more sources

Theoretical Investigation of Structural, Electronic, and Optical Properties of ZnSnP2 Semiconductor

Annals of West University of Timisoara: Physics, 2022
The structural, electronic, and optical properties of ZnSnP2 compound were determined using the first principles calculations. We applied the full-potential enhanced plane wave method (FP-LAPW) within the framework of density functional theory (DFT) as ...
Ouledali M., Amrani B., Daoud S., Louhibi-Fasla S., Rekab-Djabri H., Beloufa N., Bekheira S., Ouadha I.   +7 more
doaj   +1 more source

Neddylation modification regulates lamin B1 expression in breast cancer [PDF]

Zhongguo aizheng zazhi, 2022
Background and purpose: The role of neddylation modification in breast cancer has rarely been reported. Previous study found that neddylation modification blocking induced cellular senescence in breast cancer, however, the potential mechanism has not yet
Xiaoqing JIA, Xiaoyin SUN, Beiqi JIANG, Zhangyi MEI, Yun FU, Zhigang ZHUANG   +5 more
doaj   +2 more sources

Role of C-Terminal Phosphorylation of Lamin A in DNA Damage and Cellular Senescence

Cells, 2023
The nuclear matrix protein lamin A is a multifunctional protein with roles in DNA replication and repair, gene activation, transcriptional regulation, and maintenance of higher-order chromatin structure. Phosphorylation is the main determinant of lamin A
Ying Ao, Zhuping Wu, Zhiwei Liao, Juncong Lan, Jie Zhang, Pengfei Sun, Baohua Liu, Zimei Wang   +7 more
doaj   +1 more source