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Nuclear lamins: Structure and function in mechanobiology [PDF]
APL Bioengineering, 2022 Nuclear lamins are type V intermediate filament proteins that polymerize into complex filamentous meshworks at the nuclear periphery and in less structured forms throughout the nucleoplasm.
Amir Vahabikashi +3 more
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Nuclear Lamins: Key Proteins for Embryonic Development [PDF]
Biology, 2022 Lamins are essential components of the nuclear envelope and have been studied for decades due to their involvement in several devastating human diseases, the laminopathies.
Jasper Chrysolite Paul, Helena Fulka
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Nuclear lamins in cancer. [PDF]
Cell Mol Bioeng, 2016 Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying the main structural proteins of nuclei, the lamins, in cancer. Past studies have also demonstrated the significance of microenvironment mechanics to cancer progression, which is extremely interesting because the lamina was recently shown to be mechanosensitive ...
Irianto J +4 more
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Nuclear lamins and neurobiology. [PDF]
Mol Cell Biol, 2014 Much of the work on nuclear lamins during the past 15 years has focused on mutations in LMNA (the gene for prelamin A and lamin C) that cause particular muscular dystrophy, cardiomyopathy, partial lipodystrophy, and progeroid syndromes. These disorders, often called "laminopathies," mainly affect mesenchymal tissues (e.g., striated muscle, bone, and ...
Young SG, Jung HJ, Lee JM, Fong LG.
europepmc +6 more sources
The Paradox of Nuclear Lamins in Pathologies: Apparently Controversial Roles Explained by Tissue-Specific Mechanobiology [PDF]
Cells, 2022 The nuclear lamina is a complex meshwork of intermediate filaments (lamins) that is located beneath the inner nuclear membrane and the surrounding nucleoplasm.
Enrica Urciuoli, Barbara Peruzzi
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Nuclear Lamins in Cardiac Development and Disease [PDF]
CellsNuclear lamins organize the structural and regulatory architecture of the nucleus, integrating nuclear mechanics, chromatin organization, and genome regulation.
Siqi Li +4 more
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Cold Spring Harb Perspect Biol, 2010 The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization.
Dechat T +4 more
europepmc +4 more sources
Nuclear lamins: making contacts with promoters. [PDF]
Nucleus, 2013 The nuclear lamina guards the genome and in many ways contributes to regulating nuclear function. Increasing evidence indicates that the lamina dynamically interacts with chromatin mainly through large repressive domains, and recent data suggest that at least some of the lamin-genome contacts may be developmentally significant. In an attempt to provide
Lund E, Collas P.
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Nuclear lamins and laminopathies. [PDF]
J Pathol, 2012 AbstractNuclear lamins are intermediate filament proteins that polymerize to form the nuclear lamina on the inner aspect of the inner nuclear membrane. Long known to be essential for maintaining nuclear structure and disassembling/reassembling during mitosis in metazoans, research over the past dozen years has shown that mutations in genes encoding ...
Worman HJ.
europepmc +4 more sources
Nuclear Actin and Lamins in Viral Infections [PDF]
Viruses, 2012 Lamins are the best characterized cytoskeletal components of the cell nucleus that help to maintain the nuclear shape and participate in diverse nuclear processes including replication or transcription.
Jakub Cibulka +2 more
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