Results 1 to 10 of about 1,480,665 (235)

Nuclear lamins: Structure and function in mechanobiology [PDF]

APL Bioengineering, 2022
Nuclear lamins are type V intermediate filament proteins that polymerize into complex filamentous meshworks at the nuclear periphery and in less structured forms throughout the nucleoplasm.
Amir Vahabikashi, Stephen A. Adam, Ohad Medalia, Robert D. Goldman   +3 more
doaj   +7 more sources

Nuclear Lamins: Key Proteins for Embryonic Development [PDF]

Biology, 2022
Lamins are essential components of the nuclear envelope and have been studied for decades due to their involvement in several devastating human diseases, the laminopathies.
Jasper Chrysolite Paul, Helena Fulka
doaj   +3 more sources

The Paradox of Nuclear Lamins in Pathologies: Apparently Controversial Roles Explained by Tissue-Specific Mechanobiology [PDF]

Cells, 2022
The nuclear lamina is a complex meshwork of intermediate filaments (lamins) that is located beneath the inner nuclear membrane and the surrounding nucleoplasm.
Enrica Urciuoli, Barbara Peruzzi
doaj   +2 more sources

Nuclear Lamins in Cardiac Development and Disease [PDF]

Cells
Nuclear lamins organize the structural and regulatory architecture of the nucleus, integrating nuclear mechanics, chromatin organization, and genome regulation.
Siqi Li, Rui Li, Chun Liu, Dongzhu Xu, Lu Han   +4 more
doaj   +2 more sources

Antagonistic contributions of A-type and B-type lamins to LBR localization and dynamics [PDF]

Nucleus
Lamin B receptor (LBR) is an inner nuclear membrane protein that organizes peripheral heterochromatin and cooperates with lamins to tether chromatin at the nuclear periphery.
Jacob Odell, Kristen Nedza, Alexander Sopilniak-Mints, Jan Lammerding   +3 more
doaj   +2 more sources

The Lamin Proteins in Nuclear Structure, Functions, and Laminopathies [PDF]

Cells
The lamin proteins are classified into A- and B-types, and together with their associated proteins, they form the nuclear lamina, which governs diverse nuclear structures and functions, including nuclear mechanics, chromatin organization, and gene ...
Gan Zhao, Ziheng Chen, Caifeng Yang, Mingzheng Liu, Weiyong Wang, Chuanmao Zhang   +5 more
doaj   +2 more sources

Quantifying intracellular mechanosensitive response upon spatially defined mechano-chemical triggering [PDF]

eLife
The mechanotransduction process relies on the interaction of mechanical and biochemical cues, transmitting cellular forces to intracellular organelles to activate biochemical pathways and elicit responses.
Elaheh Zare-Eelanjegh, Renard TM Lewis, Ines Lüchtefeld, Ulrike Kutay, Tomaso Zambelli   +4 more
doaj   +2 more sources

Mechanisms of A-Type Lamin Targeting to Nuclear Ruptures Are Disrupted in LMNA- and BANF1-Associated Progerias

Cells, 2022
Mutations in the genes LMNA and BANF1 can lead to accelerated aging syndromes called progeria. The protein products of these genes, A-type lamins and BAF, respectively, are nuclear envelope (NE) proteins that interact and participate in various cellular ...
Rhiannon M. Sears, Kyle J. Roux
doaj   +1 more source

Effects of mutant lamins on nucleo-cytoskeletal coupling in Drosophila models of LMNA muscular dystrophy

Frontiers in Cell and Developmental Biology, 2022
The nuclei of multinucleated skeletal muscles experience substantial external force during development and muscle contraction. Protection from such forces is partly provided by lamins, intermediate filaments that form a scaffold lining the inner nuclear ...
Nicholas M. Shaw, Jose L. Rios-Monterrosa, Gregory R. Fedorchak, Margaret R. Ketterer, Gary S. Coombs, Jan Lammerding, Lori L. Wallrath   +6 more
doaj   +1 more source

A-type lamins involvement in transport and implications in cancer?

Nucleus, 2022
Nuclear lamins and transport are intrinsically linked, but their relationship is yet to be fully unraveled. A multitude of complex, coupled interactions between lamins and nucleoporins (Nups), which mediate active transport into and out of the nucleus ...
Nicholas R. Scott, Sapun H. Parekh
doaj   +1 more source