Results 11 to 20 of about 1,480,665 (235)
Nuclear Actin and Lamins in Viral Infections [PDF]
Viruses, 2012 Lamins are the best characterized cytoskeletal components of the cell nucleus that help to maintain the nuclear shape and participate in diverse nuclear processes including replication or transcription.
Jakub Cibulka +2 more
doaj +4 more sources
Nuclear lamins and neurobiology. [PDF]
Mol Cell Biol, 2014 Much of the work on nuclear lamins during the past 15 years has focused on mutations in LMNA (the gene for prelamin A and lamin C) that cause particular muscular dystrophy, cardiomyopathy, partial lipodystrophy, and progeroid syndromes. These disorders, often called "laminopathies," mainly affect mesenchymal tissues (e.g., striated muscle, bone, and ...
Young SG, Jung HJ, Lee JM, Fong LG.
europepmc +8 more sources
Scaffold, mechanics and functions of nuclear lamins
FEBS Letters, 2023 Nuclear lamins are type‐V intermediate filaments that are involved in many nuclear processes. In mammals, A‐ and B‐type lamins assemble into separate physical meshwork underneath the inner nuclear membrane, the nuclear lamina, with some residual fraction localized within the nucleoplasm.
Buxboim, Amnon +6 more
openaire +4 more sources
Both emerin and lamin C depend on lamin A for localization at the nuclear envelope [PDF]
, 2001 Physical interactions between lamins and emerin were investigated by co-immunoprecipitation of in vitro translated proteins. Emerin interacted with in vitro translated lamins A, B1 and C in co-immunprecipitation reactions.
Whitfield, WGF +8 more
core +7 more sources
Nuclear lamins in cancer. [PDF]
Cell Mol Bioeng, 2016 Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying the main structural proteins of nuclei, the lamins, in cancer. Past studies have also demonstrated the significance of microenvironment mechanics to cancer progression, which is extremely interesting because the lamina was recently shown to be mechanosensitive ...
Irianto J +4 more
europepmc +5 more sources
Unweaving the role of nuclear Lamins in neural circuit integrity. [PDF]
Cell Stress, 2018 Lamins are type-V intermediate filament proteins that comprise the nuclear lamina. Although once considered static structural components that provide physical support to the inner nuclear envelope, recent studies are revealing additional functional and ...
Deal SL, Yamamoto S.
europepmc +2 more sources
Discovery and restoration of Aberrant Nuclear structure and Genome behaviour in breast cancer cells [PDF]
, 2013 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The eukaryotic interphase nucleus is well organised and the genome positioned non-randomly.
Hassan Ahmed, Mai
core +7 more sources
Nuclear lamins: making contacts with promoters. [PDF]
Nucleus, 2013 The nuclear lamina guards the genome and in many ways contributes to regulating nuclear function. Increasing evidence indicates that the lamina dynamically interacts with chromatin mainly through large repressive domains, and recent data suggest that at least some of the lamin-genome contacts may be developmentally significant. In an attempt to provide
Lund E, Collas P.
europepmc +4 more sources
Cold Spring Harb Perspect Biol, 2010 The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization.
Dechat T +4 more
europepmc +4 more sources
Weaving a pattern from disparate threads: lamin function in nuclear assembly and DNA replication [PDF]
, 1994 The major residual structure that remains associated with the nuclear envelope following extraction of isolated nuclei or oocyte germinal vesicles with non-ionic detergents, nucleases and high salt is the lamina (Fawcett, 1966; Aaronson and Blobel ...
Hutchison, CJ +3 more
core +6 more sources