Results 11 to 20 of about 13,819 (261)
Nuclear lamins and laminopathies. [PDF]
J Pathol, 2012 AbstractNuclear lamins are intermediate filament proteins that polymerize to form the nuclear lamina on the inner aspect of the inner nuclear membrane. Long known to be essential for maintaining nuclear structure and disassembling/reassembling during mitosis in metazoans, research over the past dozen years has shown that mutations in genes encoding ...
Worman HJ.
europepmc +6 more sources
Nuclear Actin and Lamins in Viral Infections [PDF]
Viruses, 2012 Lamins are the best characterized cytoskeletal components of the cell nucleus that help to maintain the nuclear shape and participate in diverse nuclear processes including replication or transcription.
Jakub Cibulka +2 more
doaj +3 more sources
Nuclear lamins: key regulators of nuclear structure and activities [PDF]
Journal of Cellular and Molecular Medicine, 2009 The lamin molecule The supramolecular assembly of lamins Lamin‐binding proteins Lamins and aging Lamins and stem cells Lamins and cancer Lamin and viruses AbstractThe nuclear lamina is a proteinaceous structure located underneath the inner nuclear membrane (INM), where it associates with the peripheral chromatin.
Prokocimer, Miron +7 more
openaire +4 more sources
Mitotic dynamics of the nuclear lamina behind the scenes of chromosome separation [PDF]
Communications BiologyThe regulation of mitosis is essential for genome inheritance and stability. In mammals, many cellular ultrastructures, including the nuclear envelope, undergo significant morphological changes to facilitate chromosome separation.
Julien Picotto +2 more
doaj +2 more sources
Cells, 2022 Mutations in the genes LMNA and BANF1 can lead to accelerated aging syndromes called progeria. The protein products of these genes, A-type lamins and BAF, respectively, are nuclear envelope (NE) proteins that interact and participate in various cellular ...
Rhiannon M. Sears, Kyle J. Roux
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 The nuclei of multinucleated skeletal muscles experience substantial external force during development and muscle contraction. Protection from such forces is partly provided by lamins, intermediate filaments that form a scaffold lining the inner nuclear ...
Nicholas M. Shaw +6 more
doaj +1 more source
LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior
eLife, 2021 Lamins form stable filaments at the nuclear periphery in metazoans. Unlike B-type lamins, lamins A and C localize also in the nuclear interior, where they interact with lamin-associated polypeptide 2 alpha (LAP2α).
Nana Naetar +8 more
doaj +1 more source
A-type lamins involvement in transport and implications in cancer?
Nucleus, 2022 Nuclear lamins and transport are intrinsically linked, but their relationship is yet to be fully unraveled. A multitude of complex, coupled interactions between lamins and nucleoporins (Nups), which mediate active transport into and out of the nucleus ...
Nicholas R. Scott, Sapun H. Parekh
doaj +1 more source
A comparative study of Drosophila and human A-type lamins. [PDF]
PLoS ONE, 2009 Nuclear intermediate filament proteins, called lamins, form a meshwork that lines the inner surface of the nuclear envelope. Lamins contain three domains: an N-terminal head, a central rod and a C-terminal tail domain possessing an Ig-fold structural ...
Sandra R Schulze +10 more
doaj +1 more source
Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies
Nucleus, 2020 Decades of studies have established that nuclear lamin polymers form the nuclear lamina, a protein meshwork that supports the nuclear envelope structure and tethers heterochromatin to the nuclear periphery.
Sunny Yang Liu, Kohta Ikegami
doaj +1 more source