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Nuclear lamins: key regulators of nuclear structure and activities [PDF]
Journal of Cellular and Molecular Medicine, 2009 The lamin molecule The supramolecular assembly of lamins Lamin‐binding proteins Lamins and aging Lamins and stem cells Lamins and cancer Lamin and viruses AbstractThe nuclear lamina is a proteinaceous structure located underneath the inner nuclear membrane (INM), where it associates with the peripheral chromatin.
Yosef Gruenbaum, Eran Meshorer
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Journal of Cell Biology, 2000 At the end of mitosis, the nuclear lamins assemble to form the nuclear lamina during nuclear envelope formation in daughter cells. We have fused A- and B-type nuclear lamins to the green fluorescent protein to study this process in living cells. The results reveal that the A- and B-type lamins exhibit different pathways of assembly. In the early stages
Robert Goldman +2 more
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Antagonistic contributions of A-type and B-type lamins to LBR localization and dynamics [PDF]
NucleusLamin B receptor (LBR) is an inner nuclear membrane protein that organizes peripheral heterochromatin and cooperates with lamins to tether chromatin at the nuclear periphery.
Jacob Odell +3 more
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The Lamin Proteins in Nuclear Structure, Functions, and Laminopathies [PDF]
CellsThe lamin proteins are classified into A- and B-types, and together with their associated proteins, they form the nuclear lamina, which governs diverse nuclear structures and functions, including nuclear mechanics, chromatin organization, and gene ...
Gan Zhao +5 more
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Quantifying intracellular mechanosensitive response upon spatially defined mechano-chemical triggering [PDF]
eLifeThe mechanotransduction process relies on the interaction of mechanical and biochemical cues, transmitting cellular forces to intracellular organelles to activate biochemical pathways and elicit responses.
Elaheh Zare-Eelanjegh +4 more
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Nuclear Lamins and Emerin Are Differentially Expressed in Osteosarcoma Cells and Scale with Tumor Aggressiveness [PDF]
Cancers, 2020 Valentina D'Oria +2 more
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Targeted Regulation of Nuclear Lamins by Ubiquitin and Ubiquitin-Like Modifiers [PDF]
Cells, 2020 Michael Blank, Blank Michael
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Mitotic dynamics of the nuclear lamina behind the scenes of chromosome separation [PDF]
Communications BiologyThe regulation of mitosis is essential for genome inheritance and stability. In mammals, many cellular ultrastructures, including the nuclear envelope, undergo significant morphological changes to facilitate chromosome separation.
Julien Picotto +2 more
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Cells, 2022 Mutations in the genes LMNA and BANF1 can lead to accelerated aging syndromes called progeria. The protein products of these genes, A-type lamins and BAF, respectively, are nuclear envelope (NE) proteins that interact and participate in various cellular ...
Rhiannon M. Sears, Kyle J. Roux
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Frontiers in Cell and Developmental Biology, 2022 The nuclei of multinucleated skeletal muscles experience substantial external force during development and muscle contraction. Protection from such forces is partly provided by lamins, intermediate filaments that form a scaffold lining the inner nuclear ...
Nicholas M. Shaw +6 more
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