Results 1 to 10 of about 118,592,744 (196)

Lamin B1 loss in human cardiomyocytes is associated with nuclear shape deformation in dilated cardiomyopathy [PDF]

Journal of Molecular and Cellular Cardiology Plus
Dilated cardiomyopathy (DCM) is a progressive heart muscle disease characterized by the enlargement of the heart's left ventricle. The aetiology of the disease can be genetic and/or environmental.
Leandro N. Ventimiglia, Aleksej Zelezniak, Cristobal G. dos Remedios, Sean Lal, Elisabeth Ehler, Gian F. De Nicola   +5 more
doaj   +2 more sources

Lamin B1 safeguards the B cell genome and shapes lymphoma outcome [PDF]

HemaSphere
Lamin B1 is a structural component of the nuclear lamina that participates in genome organization and transcriptional control. During adaptive immune responses, B lymphocytes in germinal centers (GCs) undergo clonal expansion and programmed DNA damage at
Filip Filipsky, Katarina B. Chapman, Johannes Bloehdorn, Oscar Maiques, Abigail Lee, Andrew Clear, Jun Wang, John Gribben, Michael Hausmann, Christoph Cremer, Andrejs Braun, Marta C. Sallan, Tanya Klymenko   +12 more
doaj   +2 more sources

The Dynamics of Lamin a During the Cell Cycle

Frontiers in Molecular Biosciences, 2021
Lamin proteins play an essential role in maintaining the nuclear organization and integrity; and lamin A, in particular, plays a major role in the whole volume of the nuclear interior.
Anat Vivante, Irit Shoval, Yuval Garini, Yuval Garini   +3 more
doaj   +1 more source

Differential Gene Expression Signatures and Cellular Signaling Pathways induced by Lamin A/C Transcript Variants in MCF7 Cell Line

Frontiers in Bioscience-Landmark, 2023
Background: Lamins are the major component of nuclear lamina. Alternative splicing of the 12 exons comprising lamin A/C gene creates five known transcript variants, lamin A, lamin C, lamin AΔ10, lamin AΔ50, and lamin C2. The main objective for this study
Lin Batha, Mohammad Azhar Aziz, Mahmoud Zhra, Jasmine Holail, Wedad S. Al-Qahtani, Rajaa Fakhoury, Ahmad Aljada   +6 more
doaj   +1 more source

LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

eLife, 2021
Lamins form stable filaments at the nuclear periphery in metazoans. Unlike B-type lamins, lamins A and C localize also in the nuclear interior, where they interact with lamin-associated polypeptide 2 alpha (LAP2α).
Nana Naetar, Konstantina Georgiou, Christian Knapp, Irena Bronshtein, Elisabeth Zier, Petra Fichtinger, Thomas Dechat, Yuval Garini, Roland Foisner   +8 more
doaj   +1 more source

Lamin A and Prelamin a Counteract Migration of Osteosarcoma Cells

Cells, 2020
A type lamins are fundamental components of the nuclear lamina. Changes in lamin A expression correlate with malignant transformation in several cancers. However, the role of lamin A has not been explored in osteosarcoma (OS).
Camilla Evangelisti, Francesca Paganelli, Gaia Giuntini, Elisabetta Mattioli, Alessandra Cappellini, Giulia Ramazzotti, Irene Faenza, Maria Cristina Maltarello, Alberto M. Martelli, Katia Scotlandi, Francesca Chiarini, Giovanna Lattanzi   +11 more
doaj   +1 more source

Role of C-Terminal Phosphorylation of Lamin A in DNA Damage and Cellular Senescence

Cells, 2023
The nuclear matrix protein lamin A is a multifunctional protein with roles in DNA replication and repair, gene activation, transcriptional regulation, and maintenance of higher-order chromatin structure. Phosphorylation is the main determinant of lamin A
Ying Ao, Zhuping Wu, Zhiwei Liao, Juncong Lan, Jie Zhang, Pengfei Sun, Baohua Liu, Zimei Wang   +7 more
doaj   +1 more source

A novel role of lamins from genetic disease to cancer biomarkers

Oncology Reviews, 2016
Lamins are the key components of the nuclear lamina and by virtue of their interactions with chromatin and binding partners act as regulators of cell proliferation and differentiation.
Kunnathur Murugesan Sakthivel, Poonam Sehgal   +1 more
doaj   +1 more source

Role of Lamin A/C as Candidate Biomarker of Aggressiveness and Tumorigenicity in Glioblastoma Multiforme

Biomedicines, 2021
Nuclear lamina components have long been regarded as scaffolding proteins, forming a dense fibrillar structure necessary for the maintenance of the nucleus shape in all the animal kingdom.
Giuliana Gatti, Laura Vilardo, Carla Musa, Chiara Di Pietro, Fabrizio Bonaventura, Ferdinando Scavizzi, Alessio Torcinaro, Barbara Bucci, Raffaele Saporito, Ivan Arisi, Francesca De Santa, Marcello Raspa, Loredana Guglielmi, Igea D’Agnano   +13 more
doaj   +1 more source

GENDER FEATURES OF LAMINA CONTENT IN HUMAN SKIN FIBROBLASTS IN A PROCESS OF CHRONOLOGICAL AGING

Сибирский научный медицинский журнал, 2019
The purpose of the study was to investigate gender peculiarities of the content of fibroblasts immunopositive to lamins A, B1 and B2 in skin samples in a process of chronological aging. Material and methods.
N. N. Golubtsova, A. V. Bogdanov, A. G. Gunin   +2 more
doaj   +1 more source