Results 31 to 40 of about 42,713 (231)

Lamins at a glance [PDF]

Journal of Cell Science, 2012
Lamins, the major components of the nuclear lamina, have gained rapidly increasing interest over the past decade as lamin mutations were found to cause numerous devastating diseases. These laminopathies include Emery–Dreifuss muscular dystrophy (EDMD), dilated cardiomyopathy type 1A, limb ...
Chin Yee, Ho, Jan, Lammerding
openaire   +2 more sources

Association of obstetrics and foetal ultrasound parameters with maternal serum Lamin A: A teaching institution-based cross-sectional study

Journal of Family Medicine and Primary Care
Introduction: Ultrasound imaging is commonly used during pregnancy to detect potential foetal anomalies. Lamin A (LMNA), a nuclear envelope protein, has been identified as a potential biomarker for predicting adverse pregnancy outcomes.
Kumar Ranjit, Jiut Ram Keshari, Prabhakar Pankaj, Prakash Pritam, Rani Kirti, Prasad Dipali   +5 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Altered protein dynamics of disease-associated lamin A mutants

BMC Cell Biology, 2004
Background Recent interest in the function of the nuclear lamina has been provoked by the discovery of lamin A/C mutations in the laminopathy diseases. However, it is not understood why mutations in lamin A give such a range of tissue-specific phenotypes.
Worman Howard J, Östlund Cecilia, Perry Paul, Gilbert Nick, Gilchrist Susan, Bickmore Wendy A   +5 more
doaj   +1 more source

Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

Journal of Translational Medicine, 2023
Background Dilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on DCM have revealed diverse aetiologies.
Chia Yee Tan, Pui Shi Chan, Hansen Tan, Sung Wei Tan, Chang Jie Mick Lee, Jiong-Wei Wang, Shu Ye, Hendrikje Werner, Ying Jie Loh, Yin Loon Lee, Matthew Ackers-Johnson, Roger S. Y. Foo, Jianming Jiang   +12 more
doaj   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Mechanotransduction of the vasculature in Hutchinson-Gilford Progeria Syndrome

Frontiers in Physiology
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disorder that causes severe cardiovascular disease, resulting in the death of patients in their teenage years.
Kevin L. Shores, George A. Truskey
doaj   +1 more source

Statins and Histone Deacetylase Inhibitors Affect Lamin A/C – Histone Deacetylase 2 Interaction in Human Cells

Frontiers in Cell and Developmental Biology, 2019
We recently identified lamin A/C as a docking molecule for human histone deacetylase 2 (HDAC2) and showed involvement of HDAC2-lamin A/C complexes in the DNA damage response.
Elisabetta Mattioli, Elisabetta Mattioli, Davide Andrenacci, Davide Andrenacci, Antonello Mai, Sergio Valente, Joke Robijns, Winnok H. De Vos, Cristina Capanni, Cristina Capanni, Giovanna Lattanzi, Giovanna Lattanzi   +11 more
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

The different function of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C.

PLoS ONE, 2012
Lamins' functions are regulated by phosphorylation at specific sites but our understanding of the role of such modifications is practically limited to the function of cdc 2 (cdk1) kinase sites in depolymerization of the nuclear lamina during mitosis.
Magdalena Zaremba-Czogalla, Katarzyna Piekarowicz, Katarzyna Wachowicz, Katarzyna Kozioł, Magda Dubińska-Magiera, Ryszard Rzepecki   +5 more
doaj   +1 more source