Results 31 to 40 of about 118,592,744 (196)

Nuclear Lamins [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization.
Thomas, Dechat, Stephen A, Adam, Pekka, Taimen, Takeshi, Shimi, Robert D, Goldman   +4 more
openaire   +2 more sources

Influences of lamin A levels on induction of pluripotent stem cells

Biology Open, 2012
Summary Lamin A is an inner nuclear membrane protein that maintains nuclear structure integrity, is involved in transcription, DNA damage response and genomic stability, and also links to cell differentiation, senescence, premature aging and associated ...
Bingfeng Zuo, Jiao Yang, Fang Wang, Lei Wang, Yu Yin, Jiameng Dan, Na Liu, Lin Liu   +7 more
doaj   +1 more source

Association of obstetrics and foetal ultrasound parameters with maternal serum Lamin A: A teaching institution-based cross-sectional study

Journal of Family Medicine and Primary Care
Introduction: Ultrasound imaging is commonly used during pregnancy to detect potential foetal anomalies. Lamin A (LMNA), a nuclear envelope protein, has been identified as a potential biomarker for predicting adverse pregnancy outcomes.
Kumar Ranjit, Jiut Ram Keshari, Prabhakar Pankaj, Prakash Pritam, Rani Kirti, Prasad Dipali   +5 more
doaj   +1 more source

Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

Journal of Translational Medicine, 2023
Background Dilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on DCM have revealed diverse aetiologies.
Chia Yee Tan, Pui Shi Chan, Hansen Tan, Sung Wei Tan, Chang Jie Mick Lee, Jiong-Wei Wang, Shu Ye, Hendrikje Werner, Ying Jie Loh, Yin Loon Lee, Matthew Ackers-Johnson, Roger S. Y. Foo, Jianming Jiang   +12 more
doaj   +1 more source

Unicritical laminations

Fundamenta Mathematicae, 2022
35 pages, 1 figure; keywords: complex dynamics, circle dynamics ...
Bhattacharya, Sourav, Blokh, Alexander, Schleicher, Dierk   +2 more
openaire   +2 more sources

Lamin A conformation modelling

, 2019
Data in support of manuscript: "Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity" Lamin A is a nuclear intermediate filament protein critical for nuclear architecture and mechanics and mutated in a wide range of ...
Rappsilber, Juri, Houston, Douglas R, Zou, Juan, Cardenal-Peralta, Cristina, Solovyova, Alexandra S, Schirmer, Eric C, Makarov, Alex A, Spanos, Christos   +7 more
core   +2 more sources

Altered protein dynamics of disease-associated lamin A mutants

BMC Cell Biology, 2004
Background Recent interest in the function of the nuclear lamina has been provoked by the discovery of lamin A/C mutations in the laminopathy diseases. However, it is not understood why mutations in lamin A give such a range of tissue-specific phenotypes.
Worman Howard J, Östlund Cecilia, Perry Paul, Gilbert Nick, Gilchrist Susan, Bickmore Wendy A   +5 more
doaj   +1 more source

Internal iamin structures within G1 nuclei of human dermal fibroblasts [PDF]

, 1993
The nuclear lamina is a mesh-like network of fibres subjacent to the inner nuclear membrane that is believed to be involved in the specific spatial reorganisation of chromatin after mitosis.
Kill, IR, Hutchison, CJ, O’Farrell, M, Bridger, JM   +3 more
core   +4 more sources

Mechanotransduction of the vasculature in Hutchinson-Gilford Progeria Syndrome

Frontiers in Physiology
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disorder that causes severe cardiovascular disease, resulting in the death of patients in their teenage years.
Kevin L. Shores, George A. Truskey
doaj   +1 more source

Statins and Histone Deacetylase Inhibitors Affect Lamin A/C – Histone Deacetylase 2 Interaction in Human Cells

Frontiers in Cell and Developmental Biology, 2019
We recently identified lamin A/C as a docking molecule for human histone deacetylase 2 (HDAC2) and showed involvement of HDAC2-lamin A/C complexes in the DNA damage response.
Elisabetta Mattioli, Elisabetta Mattioli, Davide Andrenacci, Davide Andrenacci, Antonello Mai, Sergio Valente, Joke Robijns, Winnok H. De Vos, Cristina Capanni, Cristina Capanni, Giovanna Lattanzi, Giovanna Lattanzi   +11 more
doaj   +1 more source