Results 1 to 10 of about 1,727,162 (300)

The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence [PDF]

Open Biology, 2016
AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression.
Romina Burla, Mariateresa Carcuro, Mattia La Torre, Federica Fratini, Marco Crescenzi, Maria Rosaria D'Apice, Paola Spitalieri, Grazia Daniela Raffa, Letizia Astrologo, Giovanna Lattanzi, Enrico Cundari, Domenico Raimondo, Annamaria Biroccio, Maurizio Gatti, Isabella Saggio   +14 more
doaj   +5 more sources

Regulation of Lipid Metabolism by Lamin in Mutation-Related Diseases

Frontiers in Pharmacology, 2022
Nuclear lamins, known as type 5 intermediate fibers, are composed of lamin A, lamin C, lamin B1, and lamin B2, which are encoded by LMNA and LMNB genes, respectively.
Yue Peng, Qianyu Tang, Fan Xiao, Nian Fu, Nian Fu   +4 more
doaj   +2 more sources

Variable A-type lamin expression in Merkel cell carcinoma cell lines and its association with nuclear integrity [PDF]

Scientific Reports
Merkel cell carcinoma (MCC) is an aggressive type of neuro-endocrine skin cancer and can be subdivided into Merkel cell polyomavirus (MCPyV)-positive and MCPyV-negative cases.
Merel Stiekema, Charlotte van Gorp, Amanda Macamo, Axel zur Hausen, Marc A. M. J. van Zandvoort, Frans C. S. Ramaekers, Jos L. V. Broers   +6 more
doaj   +2 more sources

ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation

Cell Reports
Summary: LMNA gene mutation can cause muscular dystrophy, and post-translational modification plays a critical role in regulating its function. Here, we identify that lamin A is palmitoylated at cysteine 522, 588, and 591 residues, which are reversely ...
Yuan Shen, Liang-Liang Zheng, Cai-Yun Fang, Yao-Yao Xu, Chao Wang, Jin-Tao Li, Ming-Zhu Lei, Miao Yin, Hao-Jie Lu, Qun-Ying Lei, Jia Qu   +10 more
doaj   +2 more sources

Drosophila as a Model for Studying the Roles of Lamins in Normal Tissues and Laminopathies [PDF]

Cells
Nuclear processes are fundamental to the regulation of cellular, tissue, and organismal function, especially in complex multicellular systems. Central to these processes are lamins and lamin-associated proteins, which contribute to nuclear structure ...
Aleksandra Zielińska, Marta Rowińska, Aleksandra Tomczak, Ryszard Rzepecki   +3 more
doaj   +2 more sources

Lamin A/C Assembly Defects in LMNA-Congenital Muscular Dystrophy Is Responsible for the Increased Severity of the Disease Compared with Emery–Dreifuss Muscular Dystrophy

Cells, 2020
LMNA encodes for Lamin A/C, type V intermediate filaments that polymerize under the inner nuclear membrane to form the nuclear lamina. A small fraction of Lamin A/C, less polymerized, is also found in the nucleoplasm. Lamin A/C functions include roles in
Anne T. Bertrand, Astrid Brull, Feriel Azibani, Louise Benarroch, Khadija Chikhaoui, Colin L. Stewart, Ohad Medalia, Rabah Ben Yaou, Gisèle Bonne   +8 more
doaj   +2 more sources

An evolutionarily conserved role for separase in the regulation of nuclear lamins [PDF]

Cell Death Discovery
Separase is a well-conserved endopeptidase that facilitates sister chromatid separation at the metaphase-anaphase transition by cleaving cohesins. Beyond its role in chromosome segregation, Separase also participates in various biological processes ...
Francesca Cipressa, Gaëlle Pennarun, Giuseppe Bosso, Serena Rosignoli, Liliana Tullo, Nadia Schiralli, Claudia Di Dio, Chiara Borghi, Alessandro Paiardini, Giuseppe Esposito, Michael Lewis Goldberg, Pascale Bertrand, Giovanni Cenci   +12 more
doaj   +2 more sources

Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

BMC Molecular and Cell Biology, 2019
Background Nuclear lamins are type V intermediate filament proteins that maintain nuclear structure and function. Furthermore, Emerin - an interactor of Lamin A/C, facilitates crosstalk between the cytoskeleton and the nucleus as it also interacts with ...
Devika Ranade, Roopali Pradhan, Muhunden Jayakrishnan, Sushmitha Hegde, Kundan Sengupta   +4 more
doaj   +2 more sources

Lamin A/C protects chromatin accessibility during mechanical loading in human skeletal muscle [PDF]

Cell Communication and Signaling
Background Skeletal muscle nuclei (myonuclei) are subjected to high mechanical stress which plays a critical role in muscle tissue integrity and plasticity.
Saline Jabre, Emeline Cherchame, Natalia Pinzón, Eline Lemerle, Marc Bitoun, Catherine Coirault   +5 more
doaj   +2 more sources

Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2

Diabetes, 2021
Mechanisms by which autosomal recessive mutations in Lmna cause familial partial lipodystrophy type 2 (FPLD2) are poorly understood. To investigate the function of lamin A/C in adipose tissue, we created mice with an adipocyte-specific loss of Lmna ...
C. Corsa, Carolyn M. Walsh, Devika P. Bagchi, Maria C Foss Freitas, Ziru Li, Julie Hardij, Katrina Granger, H. Mori, Rebecca L. Schill, Kenneth T. Lewis, J. Maung, R. Azaria, A. Rothberg, E. Oral, O. MacDougald   +14 more
semanticscholar   +1 more source