Results 41 to 50 of about 36,018 (236)
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Increased Lamin B1 Levels Promote Cell Migration by Altering Perinuclear Actin Organization
Cells, 2020 Cell migration requires reposition and reshaping of the cell nucleus. The nuclear lamina is highly important for migration of both primary and cancer cells.
Andrea Fracchia +3 more
doaj +1 more source
The nucleoplasmic interactions among Lamin A/C-pRB-LAP2α-E2F1 are modulated by dexamethasone
Scientific Reports, 2021 Ataxia telangiectasia (AT) is a rare genetic neurodegenerative disease. To date, there is no available cure for the illness, but the use of glucocorticoids has been shown to alleviate the neurological symptoms associated with AT.
Anastasia Ricci +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Invaginations of the nuclear membrane occur in different shapes, sizes, and compositions. Part of these pleiomorphic invaginations make up the nucleoplasmic reticulum (NR), while others are merely nuclear folds.
Merel Stiekema +16 more
doaj +1 more source
Topological type of limit laminations of embedded minimal disks [PDF]
Journal of Differential Geometry, 2016 21 pages.
Bernstein, Jacob, Tinaglia, Giuseppe
openaire +3 more sources
Genome organization in cardiomyocytes expressing mutated A-type lamins
Frontiers in Cell and Developmental Biology, 2022 Cardiomyopathy is a myocardial disorder, in which the heart muscle is structurally and functionally abnormal, often leading to heart failure. Dilated cardiomyopathy is characterized by a compromised left ventricular function and contributes significantly to the heart failure epidemic, which represents a staggering clinical and public health problem ...
Kervella, Marie +3 more
openaire +4 more sources
A-type lamins and cardiovascular disease in premature aging syndromes [PDF]
Current Opinion in Cell Biology, 2017 Lamin A is a nuclear intermediate filament protein with important structural and regulatory roles in most differentiated mammalian cells. Excessive accumulation of its precursor prelamin A or the mutant form called 'progerin' causes premature aging syndromes.
Dorado, Beatriz, Andres, Vicente
openaire +3 more sources
B-type lamins in health and disease
Seminars in Cell & Developmental Biology, 2014 For over two decades, B-type lamins were thought to have roles in fundamental processes including correct assembly of nuclear envelopes, DNA replication, transcription and cell survival. Recent studies have questioned these roles and have instead emphasised the role of these proteins in tissue building and tissue integrity, particularly in tissues ...
openaire +4 more sources
A progeroid syndrome in mice is caused by defects in A-type lamins [PDF]
Nature, 2003 Numerous studies of the underlying causes of ageing have been attempted by examining diseases associated with premature ageing, such as Werner's syndrome and Hutchinson-Gilford progeria syndrome (HGPS). HGPS is a rare genetic disorder resulting in phenotypes suggestive of accelerated ageing, including shortened stature, craniofacial disproportion, very
Mounkes, Leslie C. +4 more
openaire +2 more sources
Lamin A, Chromatin and FPLD2: Not Just a Peripheral Ménage-à-Trois
Frontiers in Cell and Developmental Biology, 2018 At the nuclear periphery, the genome is anchored to A- and B-type nuclear lamins in the form of heterochromatic lamina-associated domains. A-type lamins also associate with chromatin in the nuclear interior, away from the peripheral nuclear lamina.
Nolwenn Briand +8 more
doaj +1 more source