Results 51 to 60 of about 1,727,162 (300)

Surface Roughness Gradients Reveal Topography‐Specific Mechanosensitive Responses in Human Mesenchymal Stem Cells [PDF]

, 2020
The topographic features of an implant, which mechanically regulate cell behaviors and functions, are critical for the clinical success in tissue regeneration.
Camacho, Luis Cuellar, Haag, Rainer, Hou, Yong, Nie, Chuanxiong, Wei, Qiang, Xie, Wenyan, Yu, Leixiao, Zhang, Man   +7 more
core   +1 more source

Identification of a Novel Muscle A-type Lamin-interacting Protein (MLIP) [PDF]

Journal of Biological Chemistry, 2011
Mutations in the A-type lamin (LMNA) gene are associated with age-associated degenerative disorders of mesenchymal tissues, such as dilated cardiomyopathy, Emery-Dreifuss muscular dystrophy, and limb-girdle muscular dystrophy. The molecular mechanisms that connect mutations in LMNA with different human diseases are poorly understood.
Ahmady, Elmira, Deeke, Shelley A., Rabaa, Seham, Kouri, Lara, Kenney, Laura, Stewart, Alexandre F. R., Burgon, Patrick G.   +6 more
openaire   +2 more sources

The large fraction of heterochromatin in Drosophila neurons is bound by both B-type lamin and HP1a

Epigenetics & Chromatin, 2018
BackgroundIn most mammalian cell lines, chromatin located at the nuclear periphery is represented by condensed heterochromatin, as evidenced by microscopy observations and DamID mapping of lamina-associated domains (LADs) enriched in dimethylated Lys9 of
A. Pindyurin, Artem A. Ilyin, A. V. Ivankin, Mikhail V. Tselebrovsky, Valentina V. Nenasheva, E. Mikhaleva, Ludo Pagie, B. van Steensel, Y. Y. Shevelyov   +8 more
semanticscholar   +1 more source

Cytoplasmic chromatin triggers inflammation in senescence and cancer [PDF]

, 2017
Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a ...
Adams, Peter D., Ahasan Al Tanim, K.M., Barber, Glen N., Berger, Shelley L., Capell, Brian C., Dou, Zhixun, Garcia, Benjamin A., Ghosh, Kanad, Jiang, Tianying, Kaestner, Klaus H., Kieckhaefer, Julia E., Lan, Yemin, Lin, Yanping, Millar, Sarah E., Sen, Payel, Seykora, John T., Shoshkes-Carmel, Michal, Simithy, Johayra, Vizioli, Maria Grazia, Wangensteen, Kirk J., Xu, Caiyue, Xu, Mingang, Zhou, Zhuo, Zhu, Jiajun   +23 more
core   +2 more sources

A-type lamins and cardiovascular disease in premature aging syndromes [PDF]

Current Opinion in Cell Biology, 2017
Lamin A is a nuclear intermediate filament protein with important structural and regulatory roles in most differentiated mammalian cells. Excessive accumulation of its precursor prelamin A or the mutant form called 'progerin' causes premature aging syndromes.
Dorado, Beatriz, Andres, Vicente
openaire   +3 more sources

Expression of murine muscle-enriched A-type lamin-interacting protein (MLIP) is regulated by tissue-specific alternative transcription start sites

Journal of Biological Chemistry, 2018
Muscle-enriched lamin-interacting protein (Mlip) is an alternatively spliced gene whose splicing specificity is dictated by tissue type. MLIP is most abundantly expressed in brain, cardiac, and skeletal muscle.
Marie-Elodie Cattin, S. Deeke, Sarah A. Dick, Zachary J. A. Verret-Borsos, G. Tennakoon, Rishi Gupta, E. Mak, Cassandra L Roeske, Jonathan J. Weldrick, L. Megeney, P. Burgon   +10 more
semanticscholar   +1 more source

Mammalian telomeres and their partnership with lamins [PDF]

, 2016
Chromosome ends are complex structures, which require a panel of factors for their elongation, replication, and protection. We describe here the mechanics of mammalian telomeres, dynamics and maintainance in relation to lamins.
BURLA, ROMINA, LA TORRE, MATTIA, SAGGIO, Isabella   +2 more
core   +1 more source

Increased Lamin B1 Levels Promote Cell Migration by Altering Perinuclear Actin Organization

Cells, 2020
Cell migration requires reposition and reshaping of the cell nucleus. The nuclear lamina is highly important for migration of both primary and cancer cells.
Andrea Fracchia, Tal Asraf, Mali Salmon-Divon, Gabi Gerlitz   +3 more
doaj   +1 more source

The nucleoplasmic interactions among Lamin A/C-pRB-LAP2α-E2F1 are modulated by dexamethasone

Scientific Reports, 2021
Ataxia telangiectasia (AT) is a rare genetic neurodegenerative disease. To date, there is no available cure for the illness, but the use of glucocorticoids has been shown to alleviate the neurological symptoms associated with AT.
Anastasia Ricci, Sara Orazi, Federica Biancucci, Mauro Magnani, Michele Menotta   +4 more
doaj   +1 more source

The Role of Lamins in the Nucleoplasmic Reticulum, a Pleiomorphic Organelle That Enhances Nucleo-Cytoplasmic Interplay

Frontiers in Cell and Developmental Biology, 2022
Invaginations of the nuclear membrane occur in different shapes, sizes, and compositions. Part of these pleiomorphic invaginations make up the nucleoplasmic reticulum (NR), while others are merely nuclear folds.
Merel Stiekema, Merel Stiekema, Frederik Houben, Frederik Houben, Fons Verheyen, Marcel Borgers, Julia Menzel, Martin Meschkat, Marc A. M. J. van Zandvoort, Marc A. M. J. van Zandvoort, Marc A. M. J. van Zandvoort, Marc A. M. J. van Zandvoort, Frans C. S. Ramaekers, Frans C. S. Ramaekers, Jos L. V. Broers, Jos L. V. Broers, Jos L. V. Broers   +16 more
doaj   +1 more source