Results 51 to 60 of about 36,018 (236)

Nuclear mechanoprotection: From tissue atlases as blueprints to distinctive regulation of nuclear lamins

APL Bioengineering, 2022
Two meters of DNA in each of our cells must be protected against many types of damage. Mechanoprotection is increasingly understood to be conferred by the nuclear lamina of intermediate filament proteins, but very different patterns of expression and ...
Mai Wang, Irena Ivanovska, Manasvita Vashisth, Dennis E. Discher   +3 more
doaj   +1 more source

A Rare Mutation in LMNB2 Associated with Lipodystrophy Drives Premature Cell Senescence

Cells, 2021
Many proteins are causative for inherited partial lipodystrophies, including lamins, the essential constituents of the nuclear envelope scaffold called the lamina.
Alice-Anaïs Varlet, Camille Desgrouas, Cécile Jebane, Nathalie Bonello-Palot, Patrice Bourgeois, Nicolas Levy, Emmanuèle Helfer, Noémie Dubois, René Valero, Catherine Badens, Sophie Beliard   +10 more
doaj   +1 more source

Proteins that bind A-type lamins: integrating isolated clues [PDF]

Journal of Cell Science, 2004
What do such diverse molecules as DNA, actin, retinoblastoma protein and protein kinase Cα all have in common? They and additional partners bind `A-type' lamins, which form stable filaments in animal cell nuclei. Mutations in A-type lamins cause a bewildering range of tissue-specific diseases, termed `laminopathies', including Emery-Dreifuss muscular ...
Michael S, Zastrow, Sylvia, Vlcek, Katherine L, Wilson   +2 more
openaire   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Nuclear lamin A in rotator cuff tear margin tenocytes: an antiapoptotic and cell mechanostat factor

Journal of Orthopaedic Surgery and Research, 2021
Background The network of intermediate filament proteins underlying the inner nuclear membrane forms the nuclear lamin. A- and B-type lamins are the major components of the nuclear lamina. Lamins function in many nuclear activities.
Stefano Gumina, Barbara Peruzzi, Martina Leopizzi, Natale Porta, Valeria Di Maio, Carlo Della Rocca, Vittorio Candela   +6 more
doaj   +1 more source

Insights into the differences between the A- and B-type nuclear lamins [PDF]

Advances in Biological Regulation, 2012
IntroductionEarly electron microscopic studies of the structure of the nucleus in vertebrate cells identified anelectron dense layer, the fibrous lamina (Fawcett 1966) or zonula nucleum limitans (Patrizi and Poger,1967),underlyingtheinnernuclearmembrane.Biochemicalsubfractionationofisolatedratlivernucleiproduced a pore complex-lamina fraction containing ...
Stephen A, Adam, Robert D, Goldman
openaire   +2 more sources

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Differential expression of nuclear lamin subtypes in the neural cells of the adult rat cerebral cortex

IBRO Reports, 2018
Lamins are type V intermediate filament proteins that are located beneath the inner nuclear membrane. In mammalian somatic cells, LMNB1 and LMNB2 encode somatic lamins B1 and B2, respectively, and the LMNA gene is alternatively spliced to generate ...
Yasuharu Takamori, Yukie Hirahara, Taketoshi Wakabayashi, Tetsuji Mori, Taro Koike, Yosky Kataoka, Yasuhisa Tamura, Shuji Kurebayashi, Kiyoshi Kurokawa, Hisao Yamada   +9 more
doaj   +1 more source

Direct actin binding to A- and B-type lamin tails and actin filament bundling by the lamin A tail [PDF]

Nucleus, 2010
Nuclear intermediate filament networks formed by A- and B-type lamins are major components of the nucleoskeleton. Lamins have growing links to human physiology and disease including Emery-Dreifuss muscular dystrophy (EDMD), lipodystrophy, cardiomyopathy, neuropathy, cerebellar disorders and segmental accelerated 'aging' syndromes.
Dan N, Simon, Michael S, Zastrow, Katherine L, Wilson   +2 more
openaire   +2 more sources