Results 71 to 80 of about 1,727,162 (300)
A role for Tctex-1 (DYNLT1) in controlling primary cilium length [PDF]
, 2011 The microtubule motor complex cytoplasmic dynein is known to be involved in multiple processes including endomembrane organization and trafficking, mitosis, and microtubule organization.
MacCarthy-Morrogh, LJ +3 more
core +2 more sources
Genomic structure of the mouse A‐type lamin gene locus encoding somatic and germ cell‐specific lamins [PDF]
FEBS Letters, 1995 Mouse A‐type lamin genes were isolated. Structural analyses revealed that all the three known mouse A‐type lamins (A, C and C2) were coded in a single genomic locus in a 22 kilobase DNA segment. The three lamins were coded in 12, 10 and 10 exons for A, C and C2, respectively, and shared 8 exons among them.
Nakajima, Noboru, Abe, Kenji
openaire +2 more sources
Lamin A/C Haploinsufficiency Modulates the Differentiation Potential of Mouse Embryonic Stem Cells [PDF]
, 2013 BACKGROUND: Lamins are structural proteins that are the major determinants of nuclear architecture and play important roles in various nuclear functions including gene regulation and cell differentiation.
Chaturvedi, P. +4 more
core +2 more sources
Nucleus, 2010 A-type lamins provide a scaffold for tethering chromatin and protein complexes regulating nuclear structure and function. Interest in lamins increased after mutations in the LMNA gene were found to be associated with a variety of human disorders termed laminopathies. These include muscular dystrophy, cardiomyopathy, lipodystrophy, peripheral neuropathy
Gonzalez-Suarez, Ignacio +1 more
openaire +3 more sources
Lamin A, Chromatin and FPLD2: Not Just a Peripheral Ménage-à-Trois
Frontiers in Cell and Developmental Biology, 2018 At the nuclear periphery, the genome is anchored to A- and B-type nuclear lamins in the form of heterochromatic lamina-associated domains. A-type lamins also associate with chromatin in the nuclear interior, away from the peripheral nuclear lamina.
Nolwenn Briand +8 more
doaj +1 more source
Lamin post-translational modifications: emerging toggles of nuclear organization and function.
TIBS -Trends in Biochemical Sciences. Regular ed, 2021 Nuclear lamins are ancient type V intermediate filaments with diverse functions that include maintaining nuclear shape, mechanosignaling, tethering and stabilizing chromatin, regulating gene expression, and contributing to cell cycle progression. Despite
Laura A Murray-Nerger, I. Cristea
semanticscholar +1 more source
Circulation, 2021 Supplemental Digital Content is available in the text. Background: Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder characterized by premature aging and death mainly because of myocardial infarction, stroke, or heart failure. The disease is
A. Sánchez-López +17 more
semanticscholar +1 more source
Nuclear lamin A in rotator cuff tear margin tenocytes: an antiapoptotic and cell mechanostat factor
Journal of Orthopaedic Surgery and Research, 2021 Background The network of intermediate filament proteins underlying the inner nuclear membrane forms the nuclear lamin. A- and B-type lamins are the major components of the nuclear lamina. Lamins function in many nuclear activities.
Stefano Gumina +6 more
doaj +1 more source
A Rare Mutation in LMNB2 Associated with Lipodystrophy Drives Premature Cell Senescence
Cells, 2021 Many proteins are causative for inherited partial lipodystrophies, including lamins, the essential constituents of the nuclear envelope scaffold called the lamina.
Alice-Anaïs Varlet +10 more
doaj +1 more source
Scientific Reports, 2015 The nuclear lamina is a protein meshwork associated with the inner side of the nuclear envelope contributing structural, signalling and regulatory functions.
M. Kollmar
semanticscholar +1 more source