Results 91 to 100 of about 1,727,162 (300)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Differential Expression of A-Type and B-Type Lamins during Hair Cycling

PLoS ONE, 2009
Multiple genetic disorders caused by mutations that affect the proteins lamin A and C show strong skin phenotypes. These disorders include the premature aging disorders Hutchinson-Gilford progeria syndrome and mandibuloacral dysplasia, as well as restrictive dermopathy.
Mubashir, Hanif, Rosengardten, Ylva, Sagelius, Hanna, Rozell, Bjorn, Eriksson, Maria   +4 more
openaire   +5 more sources

Insulin-response epigenetic activation of Egr-1 and JunB genes at the nuclear periphery by A-type lamin-associated pY19-Caveolin-2 in the inner nuclear membrane

Nucleic Acids Research, 2015
Insulin controls transcription to sustain its physiologic effects for the organism to adapt to environmental changes added to genetic predisposition. Nevertheless, insulin-induced transcriptional regulation by epigenetic factors and in defined nuclear ...
Kyuho Jeong, Hayeong Kwon, Jaewoong Lee, Donghwan Jang, Yunbae Pak   +4 more
semanticscholar   +1 more source

Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2. [PDF]

, 2014
Lamins B1 and B2 (B-type lamins) have very similar sequences and are expressed ubiquitously. In addition, both Lmnb1- and Lmnb2-deficient mice die soon after birth with neuronal layering abnormalities in the cerebral cortex, a consequence of defective ...
Coffinier, Catherine, de Jong, Pieter J, Fong, Loren G, Jung, Hea-Jin, Lee, John M, Nobumori, Chika, Tatar, Angelica, Tu, Yiping, Wu, Daniel, Yoshinaga, Yuko, Young, Stephen G   +10 more
core  

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

The Cardiovascular Magnetic Resonance Phenotype of Lamin Heart Disease.

JACC Cardiovascular Imaging
BACKGROUND Lamin (LMNA) heart disease is a lethal form of dilated cardiomyopathy (DCM). OBJECTIVES The authors explored its cardiovascular magnetic resonance (CMR) phenotype to discover prognostically useful and subclinical biomarkers.
C. Topriceanu, Mashael Al-Farih, G. Joy, Fiona Chan, Matthew Webber, Denis C. Ilie-Ablachim, H. Shiwani, Mansoon Tamang, C. Banks, Stephen Pettit, S. E. Petersen, Benjamin O’Brien, Alun D. Hughes, William Moody, Richard P. Steeds, P. Puddu, Peter Kellman, Konstantinos Savvatis, Saidi A Mohiddin, James C. Moon, Andrea Barison, Paolo Piras, G. Captur   +22 more
semanticscholar   +1 more source

Leichtlösliche, lichtechte Perylen-Fluoreszenzfarbstoffe [PDF]

, 1988
Die Synthese von Perylenfarbstoffen 2 mit terminalen Alkylgruppen wird beschrieben. Langkettige n-Alkylgruppen führen nicht zu einer Erhöhung der Löslichkeit, sondern zu einer Erniedrigung.
Adkins, Aubert, Kitatsuji, Langhals, Langhals, Langhals, Langhals, Niobe, Pohland, Prelog, Rademacher, Rohrmann, Sadrai, Černý   +13 more
core   +1 more source

Mechanoregulatory Effects of Cell‐Scale Microwells on Epithelial Cell Phenotype

Advanced Functional Materials, EarlyView.
In small polycaprolactone microwells, A549 epithelial cells span well edges, in contrast to cells growing on flat substrates. Focal adhesion sites (yellow) concentrate at topographic boundaries, while cytoskeletal tension (magenta stress fibers) is transmitted to the nucleus (blue), reducing nuclear sphericity.
Ruiwen He, Wang Sik Lee, Phattadon Yajan, Aaron Lee, Mauro Sousa de Almeida, Sandeep Keshavan, Jozef Adamcik, Céline Loussert‐Fonta, Dimitri Vanhecke, Barbara Rothen‐Rutishauser, Alke Petri‐Fink   +10 more
wiley   +1 more source

Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy

Journal of Cell Biology, 1999
The nuclear lamina is a protein meshwork lining the nucleoplasmic face of the inner nuclear membrane and represents an important determinant of interphase nuclear architecture. Its major components are the A- and B-type lamins.
Teresa L. Sullivan, D. Escalante-Alcalde, H. Bhatt, M. Anver, N. Bhat, K. Nagashima, C. Stewart, B. Burke   +7 more
semanticscholar   +1 more source

Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway [PDF]

, 2012
Protein phosphatases play a key role in balancing the cellular responses to the transforming growth factor-beta (TGF beta) signals. Several protein phosphatases have been attributed roles in the regulation of the TGF beta pathway. Among these.
Bruce, David L., Macartney, Thomas, Sapkota, Gopal P., Shou, Weinian, Yong, Weidong   +4 more
core   +3 more sources