Results 101 to 110 of about 36,018 (236)

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Lamin b1 polymorphism influences morphology of the nuclear envelope, cell cycle progression, and risk of neural tube defects in mice.

PLoS Genetics, 2012
Neural tube defects (NTDs), including spina bifida and anencephaly, are common birth defects whose complex multigenic causation has hampered efforts to delineate their molecular basis.
Sandra C P De Castro, Ashraf Malhas, Kit-Yi Leung, Peter Gustavsson, David J Vaux, Andrew J Copp, Nicholas D E Greene   +6 more
doaj   +1 more source

Topology and dynamics of laminations in surfaces of general type

Journal of the American Mathematical Society, 2015
We study Riemann surface laminations in complex algebraic surfaces of general type. We focus on the topology and dynamics of minimal sets of holomorphic foliations and on Levi-flat hypersurfaces. We begin by providing various examples. Then our first result shows that Anosov Levi-flat hypersurfaces do not embed in surfaces of general type.
Deroin, Bertrand, Dupont, Christophe
openaire   +1 more source

Muscle‐Specific Kinase Signaling and Its Therapeutic Potential

Muscle &Nerve, EarlyView.
ABSTRACT The function of the neuromuscular junction (NMJ) is compromised in many neuromuscular diseases (NMDs) such as autoimmune or congenital myasthenia gravis (MG), amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), and muscular dystrophies.
Stine Marie Jensen, Dana L. E. Vergoossen, Maartje G. Huijbers   +2 more
wiley   +1 more source

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

PROTEOMICS, EarlyView.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling, Dounia Bouragba, Elisa Negroni, Capucine Trollet, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +6 more
wiley   +1 more source

Toasting With Strangers? Export Spillovers From Chinese Winery Acquisitions in the Bordeaux Vineyards

British Journal of Management, EarlyView.
Abstract Foreign entrants may threaten and, at the same time, present local companies with opportunities for favourable spillovers. Building on the awareness‐motivation‐capability framework, this paper aims to provide empirical evidence for a positive co‐location or spatial proximity effect of foreign presence on local peer companies’ exports.
Pierre‐Xavier Meschi, Alexandre Bohas, Anne Norheim‐Hansen   +2 more
wiley   +1 more source

The upregulation of lamin A/C as a compensatory mechanism during tight junction disruption in renal tubular cells mediated by calcium oxalate crystals

Current Research in Toxicology
Calcium oxalate monohydrate (COM), the most important crystal causing kidney stone disease, upregulates lamin A/C but downregulates zonula occludens-1 (ZO-1) in renal tubular cells.
Sudarat Hadpech, Paleerath Peerapen, Visith Thongboonkerd   +2 more
doaj   +1 more source

Measuring New Venture Legitimacy: A Multi‐dimensional Approach Using Computational Textual Analysis

British Journal of Management, EarlyView.
Abstract Legitimacy is critical for the growth, survival and performance of ventures, yet efforts to measure legitimacy empirically typically focus on a single dimension of this multi‐dimensional construct. In this article, we develop a multi‐dimensional framework for measuring legitimacy using computational text analysis.
Ali Ghods, Antonin Ricard, Bénédicte Aldebert, Eric W. Schoon   +3 more
wiley   +1 more source

High matrix stiffness promotes senescence of type II alveolar epithelial cells by lysosomal degradation of lamin A/C in pulmonary fibrosis

Respiratory Research
Background Cellular senescence is one of the key steps in the progression of pulmonary fibrosis, and the senescence of type II alveolar epithelial cells (AEC IIs) may potentially accelerate the progression of pulmonary fibrosis.
Junhui Ba, Changyu Zheng, Yimei Lai, Xin He, Yuxi Pan, Yanqiu Zhao, Huihui Xie, Benquan Wu, Xiao Deng, Nan Wang   +9 more
doaj   +1 more source

Targeting nuclear export and Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signalling in myelofibrosis: A novel combinatorial strategy that impacts intrinsic and microenvironment‐related pathways

British Journal of Haematology, EarlyView.
Selinexor targets molecular pathways critical to myelofibrosis (MF) progenitor cell fitness and demonstrates complementary activity with ruxolitinib, supporting its potential as a novel disease‐modifying therapeutic strategy for MF. Summary Myelofibrosis (MF) is a chronic myeloproliferative neoplasm (MPN) characterized by splenomegaly, constitutional ...
Trinayan Kashyap, Andrea A. Ellero, Christopher J. Walker, Marie E. Maloof, Min Lu, Lijuan Xia, Ronald Hoffman, Pietro Taverna   +7 more
wiley   +1 more source