Results 81 to 90 of about 1,727,162 (300)
Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair
Nucleic Acids Research, 2021 The integrity and regulation of the nuclear lamina is essential for nuclear organization and chromatin stability, with its dysregulation being linked to laminopathy diseases and cancer.
Laura A Murray-Nerger +4 more
semanticscholar +1 more source
Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity [PDF]
, 2013 The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies ...
Chen GL, Pattison D, Wang H, Yoshida M
core +1 more source
Perturbation of wild‐type lamin A metabolism results in a progeroid phenotype [PDF]
Aging Cell, 2008 SummaryMutations in the lamin A/C gene cause the rare genetic disorder Hutchinson–Gilford progeria syndrome (HGPS). The prevalent mutation results in the production of a mutant lamin A protein with an internal 50 amino acid deletion which causes a cellular aging phenotype characterized by growth defects, limited replicative lifespan, and nuclear ...
Jose, Candelario +4 more
openaire +2 more sources
Journal of Biological Chemistry, 2015 Background: MLIP (muscle enriched A-type lamin-interacting protein) is a unique protein of yet unknown function. Results: MLIP impacts cardiac activity of Akt/mTOR pathways and is associated with and required for precocious cardiac adaptation to stress ...
Marie-Elodie Cattin +9 more
semanticscholar +1 more source
Voltage gain effect in a ring-type magnetoelectric laminate [PDF]
Applied Physics Letters, 2004 It has been observed that a ring-type magnetoelectric laminate composite of circumferentially magnetized magnetostrictive Tb1−xDyxFe2 and circumferentially polarized piezoelectric Pb(Zr,Ti)O3 layers has a large magnetoelectric voltage gain effect, offering potential in high-power miniature transformer applications.
Dong, Shuxiang +2 more
openaire +1 more source
Perinuclear Lamin A and Nucleoplasmic Lamin B2 Characterize Two Types of Hippocampal Neurons through Alzheimer’s Disease Progression [PDF]
International Journal of Molecular Sciences, 2020 Background. Recent reports point to a nuclear origin of Alzheimer’s disease (AD). Aged postmitotic neurons try to repair their damaged DNA by entering the cell cycle. This aberrant cell cycle re-entry involves chromatin modifications where nuclear Tau and the nuclear lamin are involved.
Laura Gil +7 more
openaire +2 more sources
IBRO Reports, 2018 Lamins are type V intermediate filament proteins that are located beneath the inner nuclear membrane. In mammalian somatic cells, LMNB1 and LMNB2 encode somatic lamins B1 and B2, respectively, and the LMNA gene is alternatively spliced to generate ...
Yasuharu Takamori +9 more
doaj +1 more source
APL Bioengineering, 2022 Two meters of DNA in each of our cells must be protected against many types of damage. Mechanoprotection is increasingly understood to be conferred by the nuclear lamina of intermediate filament proteins, but very different patterns of expression and ...
Mai Wang +3 more
doaj +1 more source
Cancers, 2021 Simple Summary The nucleus is the largest and stiffest organelle of tumor cells. Cancer metastasis depends on the ability of cancer cells circulating in the blood to exit blood vessels and survive in target organs.
Francesco Roncato +15 more
semanticscholar +1 more source
MicroRNA-23a promotes myelination in the central nervous system. [PDF]
, 2013 Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment ...
Fu, Ying-Hui +5 more
core +2 more sources