Results 21 to 30 of about 1,727,162 (300)
Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies. [PDF]
PLoS ONE, 2007 Lamins are intermediate filament proteins that make up the nuclear lamina, a matrix underlying the nuclear membrane in all metazoan cells that is important for nuclear form and function.
Andrés Muñoz-Alarcón +6 more
doaj +1 more source
Nature Communications, 2020 Neural stem/progenitor cells (NSPCs) persist over the lifespan while encountering constant challenges from age or injury related brain environmental changes like elevated oxidative stress.
I. Hwang +8 more
semanticscholar +1 more source
Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease
EMBO Molecular Medicine, 2020 Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence showing that increased lamin B1 levels contribute to the pathophysiology of Huntington’s disease (HD), a CAG repeat‐associated neurodegenerative disorder.
R. Alcalá-Vida +14 more
semanticscholar +1 more source
Genome organization in cardiomyocytes expressing mutated A-type lamins
Frontiers in Cell and Developmental Biology, 2022 Cardiomyopathy is a myocardial disorder, in which the heart muscle is structurally and functionally abnormal, often leading to heart failure. Dilated cardiomyopathy is characterized by a compromised left ventricular function and contributes significantly to the heart failure epidemic, which represents a staggering clinical and public health problem ...
Kervella, Marie +3 more
openaire +4 more sources
Viscoelastic behavior of human lamin A proteins in the context of dilated cardiomyopathy. [PDF]
PLoS ONE, 2013 Lamins are intermediate filament proteins of type V constituting a nuclear lamina or filamentous meshwork which lines the nucleoplasmic side of the inner nuclear membrane.
Avinanda Banerjee +6 more
doaj +1 more source
Disruption of spermatogenesis in mice lacking A-type lamins [PDF]
Journal of Cell Science, 2004 Nuclear lamins are structural protein components of the nuclear envelope. Mutations in LMNA, the gene coding for A-type lamins, result in several human hereditary diseases, the laminopathies, which include Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, familial partial lipodystrophy and Hutchinson-Gilford progeria.
Alsheimer, M. +5 more
openaire +3 more sources
PLoS ONE, 2017 The type V intermediate filament lamins are the principal components of the nuclear matrix, including the nuclear lamina. Lamins are divided into A-type and B-type, which are encoded by three genes, LMNA, LMNB1, and LMNB2.
Elise Kaspi +16 more
doaj +1 more source
Nuclear lamin facilitates collective border cell invasion into confined spaces in vivo
Journal of Cell Biology, 2023 During Drosophila border cell migration, the B-type lamin, Lam, maintains nuclear envelope integrity, stabilizes the lead cell protrusion, and promotes cluster invasion between nurse cells.
Lauren Penfield, D. Montell
semanticscholar +1 more source
Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform. [PDF]
MHR: Basic science of reproductive medicine, 2015 The nuclear lamina (NL) is a filamentous protein meshwork, composed essentially of lamins, situated between the inner nuclear membrane and the chromatin. There is mounting evidence that the NL plays a role in spermatid differentiation during spermiogenesis.
R. Elkhatib +7 more
semanticscholar +3 more sources
Proteins that bind A-type lamins: integrating isolated clues [PDF]
Journal of Cell Science, 2004 What do such diverse molecules as DNA, actin, retinoblastoma protein and protein kinase Cα all have in common? They and additional partners bind `A-type' lamins, which form stable filaments in animal cell nuclei. Mutations in A-type lamins cause a bewildering range of tissue-specific diseases, termed `laminopathies', including Emery-Dreifuss muscular ...
Michael S, Zastrow +2 more
openaire +2 more sources