Results 21 to 30 of about 36,018 (236)
Regulation of Lipid Metabolism by Lamin in Mutation-Related Diseases
Frontiers in Pharmacology, 2022 Nuclear lamins, known as type 5 intermediate fibers, are composed of lamin A, lamin C, lamin B1, and lamin B2, which are encoded by LMNA and LMNB genes, respectively.
Yue Peng +4 more
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Disruption of spermatogenesis in mice lacking A-type lamins [PDF]
Journal of Cell Science, 2004 Nuclear lamins are structural protein components of the nuclear envelope. Mutations in LMNA, the gene coding for A-type lamins, result in several human hereditary diseases, the laminopathies, which include Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, familial partial lipodystrophy and Hutchinson-Gilford progeria.
Alsheimer, M. +5 more
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Viscoelastic behavior of human lamin A proteins in the context of dilated cardiomyopathy. [PDF]
PLoS ONE, 2013 Lamins are intermediate filament proteins of type V constituting a nuclear lamina or filamentous meshwork which lines the nucleoplasmic side of the inner nuclear membrane.
Avinanda Banerjee +6 more
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Altered protein dynamics of disease-associated lamin A mutants
BMC Cell Biology, 2004 Background Recent interest in the function of the nuclear lamina has been provoked by the discovery of lamin A/C mutations in the laminopathy diseases. However, it is not understood why mutations in lamin A give such a range of tissue-specific phenotypes.
Worman Howard J +5 more
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The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence [PDF]
Open Biology, 2016 AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression.
Romina Burla +14 more
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Expression of Drosophila lamin C is developmentally regulated: analogies with vertebrate A-type lamins [PDF]
Journal of Cell Science, 1995 ABSTRACT Vertebrate nuclear lamins form a multigene family with developmentally controlled expression. In contrast, invertebrates have long been thought to contain only a single lamin, which in Drosophila is the well-characterized lamin Dm0.
Riemer, D. +5 more
openaire +3 more sources
PLoS ONE, 2017 The type V intermediate filament lamins are the principal components of the nuclear matrix, including the nuclear lamina. Lamins are divided into A-type and B-type, which are encoded by three genes, LMNA, LMNB1, and LMNB2.
Elise Kaspi +16 more
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Role of A-type lamins in signaling, transcription, and chromatin organization [PDF]
Journal of Cell Biology, 2009 A-type lamins (lamins A and C), encoded by the LMNA gene, are major protein constituents of the mammalian nuclear lamina, a complex structure that acts as a scaffold for protein complexes that regulate nuclear structure and functions. Interest in these proteins has increased in recent years with the discovery that LMNA mutations cause a variety of ...
Andrés, Vicente +1 more
openaire +3 more sources
PLoS ONE, 2012 Lamins' functions are regulated by phosphorylation at specific sites but our understanding of the role of such modifications is practically limited to the function of cdc 2 (cdk1) kinase sites in depolymerization of the nuclear lamina during mitosis.
Magdalena Zaremba-Czogalla +5 more
doaj +1 more source
Cells, 2021 The essential components of splicing are the splicing factors accumulated in nuclear speckles; thus, we studied how DNA damaging agents and A-type lamin depletion affect the properties of these regions, positive on the SC-35 protein.
Soňa Legartová +5 more
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