Results 11 to 20 of about 36,018 (236)
Antagonistic contributions of A-type and B-type lamins to LBR localization and dynamics [PDF]
NucleusLamin B receptor (LBR) is an inner nuclear membrane protein that organizes peripheral heterochromatin and cooperates with lamins to tether chromatin at the nuclear periphery.
Jacob Odell +3 more
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A comparative study of Drosophila and human A-type lamins. [PDF]
PLoS ONE, 2009 Nuclear intermediate filament proteins, called lamins, form a meshwork that lines the inner surface of the nuclear envelope. Lamins contain three domains: an N-terminal head, a central rod and a C-terminal tail domain possessing an Ig-fold structural ...
Sandra R Schulze +10 more
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Variable A-type lamin expression in Merkel cell carcinoma cell lines and its association with nuclear integrity [PDF]
Scientific ReportsMerkel cell carcinoma (MCC) is an aggressive type of neuro-endocrine skin cancer and can be subdivided into Merkel cell polyomavirus (MCPyV)-positive and MCPyV-negative cases.
Merel Stiekema +6 more
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Nuclear Lamins in Cardiac Development and Disease [PDF]
CellsNuclear lamins organize the structural and regulatory architecture of the nucleus, integrating nuclear mechanics, chromatin organization, and genome regulation.
Siqi Li +4 more
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Lateral A11 type tetramerization in lamins [PDF]
Journal of Structural Biology, 2020 The assembly of intermediate filaments (IFs) including nuclear lamins is driven by specific interactions of the elementary coiled-coil dimers in both lateral and longitudinal direction. The assembly mode A11 is dependent on lateral tetramerization of the second coiled-coil segment (coil1b) in antiparallel fashion.
Lilina, Anastasia V. +3 more
openaire +3 more sources
LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior
eLife, 2021 Lamins form stable filaments at the nuclear periphery in metazoans. Unlike B-type lamins, lamins A and C localize also in the nuclear interior, where they interact with lamin-associated polypeptide 2 alpha (LAP2α).
Nana Naetar +8 more
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Case of mandibuloacral dysplasia with type B lipodystrophy
Indian Journal of Paediatric Dermatology, 2021 Introduction: Mandibuloacral dysplasia with type B lipodystrophy (MADB) caused by compound heterozygous mutation in the ZMPSTE24 gene is characterized by generalized lipodystrophy and short stature.
Sanober Burzin Daruwalla +3 more
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Loss of A-type lamins and genomic instability [PDF]
Cell Cycle, 2009 Research performed in the last few years has revealed important roles for the spatial and temporal organization of the genome on genome function and integrity. A challenge in the field is to determine the molecular mechanisms involved in the organization of genome function.
Gonzalez-Suarez, Ignacio +2 more
openaire +3 more sources
Nucleus, 2023 Chromatin regions that interact with the nuclear lamina are often heterochromatic, repressed in gene expression, and in the spatial B compartment. However, exceptions to this trend allow us to examine the relative impact of lamin association and spatial ...
Priyojit Das +2 more
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Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies. [PDF]
PLoS ONE, 2007 Lamins are intermediate filament proteins that make up the nuclear lamina, a matrix underlying the nuclear membrane in all metazoan cells that is important for nuclear form and function.
Andrés Muñoz-Alarcón +6 more
doaj +1 more source