Results 31 to 40 of about 82,088 (275)

Lamin A, lamin B, and lamin B receptor analogues in yeast. [PDF]

The Journal of cell biology, 1989
Previous studies have shown that turkey erythrocyte lamin B is anchored to the nuclear envelope via a 58-kD integral membrane protein termed p58 or lamin B receptor (Worman H. J., J. Yuan, G. Blobel, and S. D. Georgatos. 1988. Proc. Natl. Acad. Sci. USA. 85:8531-8534). We now identify a p58 analogue in the yeast Saccharomyces cerevisiae.
Georgatos, S. D., Maroulakou, I., Blobel, G.   +2 more
openaire   +3 more sources

Filament assembly of the C. elegans lamin in the absence of helix 1A

Nucleus, 2022
Lamins are the major constituent of the nuclear lamina, a protein meshwork underlying the inner nuclear membrane. Nuclear lamins are type V intermediate filaments that assemble into ~3.5 nm thick filaments.
Rebecca de Leeuw, Rafael Kronenberg-Tenga, Matthias Eibauer, Ohad Medalia   +3 more
doaj   +1 more source

Native lamin A/C proteomes and novel partners from heart and skeletal muscle in a mouse chronic inflammation model of human frailty

Frontiers in Cell and Developmental Biology, 2023
Clinical frailty affects ∼10% of people over age 65 and is studied in a chronically inflamed (Interleukin-10 knockout; “IL10-KO”) mouse model. Frailty phenotypes overlap the spectrum of diseases (“laminopathies”) caused by mutations in LMNA. LMNA encodes
Fatima D. Elzamzami, Arushi Samal, Adith S. Arun, Tejas Dharmaraj, Neeti R. Prasad, Alex Rendon-Jonguitud, Lauren DeVine, Jeremy D. Walston, Robert N. Cole, Katherine L. Wilson   +9 more
doaj   +1 more source

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. [PDF]

, 2018
The nucleus is physically linked to the cytoskeleton, adhesions, and extracellular matrix-all of which sustain forces, but their relationships to DNA damage are obscure. We show that nuclear rupture with cytoplasmic mislocalization of multiple DNA repair
Alshareeda, Alvey, Andrea J. Liu, Broers, Burma, Buxboim, Buxboim, Capo-chichi, Chang, Charlotte R. Pfeifer, Coffinier, Cory M. Alvey, Cumming, Darzynkiewicz, Das, Dazhen Liu, de la Rosa, De Vos, Denais, Dennis E. Discher, Dingal, Docheva, Elosegui-Artola, Fong, Frigault, Grundy, Gudmundsdottir, Harada, Harding, Hatch, Hategan, Hernandez, Irena L. Ivanovska, Irianto, Ivanovska, Jerome Irianto, Jiazheng Ji, Kaspi, Kuangzheng Zhu, Lammerding, Larrieu, Levental, Lucas Smith, Nuciforo, Odde, Oh, Raab, Rachel R. Bennett, Roger A. Greenberg, Saez, Samudram, Sangkyun Cho, Schneider, Seluanov, Shin, Soubeyrand, Staszewski, Swift, Takaki, Tamiello, Tang, Turgay, Wang, Yuntao Xia, Álvarez-Quilón   +64 more
core   +2 more sources

Influences of lamin A levels on induction of pluripotent stem cells

Biology Open, 2012
Summary Lamin A is an inner nuclear membrane protein that maintains nuclear structure integrity, is involved in transcription, DNA damage response and genomic stability, and also links to cell differentiation, senescence, premature aging and associated ...
Bingfeng Zuo, Jiao Yang, Fang Wang, Lei Wang, Yu Yin, Jiameng Dan, Na Liu, Lin Liu   +7 more
doaj   +1 more source

Altered stability of nuclear lamin-B marks the onset of aging in male Drosophila.

PLoS ONE, 2022
Epigenetic alterations occur during aging, but it remains unclear what epigenetic features are associated with the onset of physiological decline in animals.
Wei-Qi Lin, Zhen-Kai Ngian, Tong-Wey Koh, Chin-Tong Ong   +3 more
doaj   +1 more source

The different function of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C.

PLoS ONE, 2012
Lamins' functions are regulated by phosphorylation at specific sites but our understanding of the role of such modifications is practically limited to the function of cdc 2 (cdk1) kinase sites in depolymerization of the nuclear lamina during mitosis.
Magdalena Zaremba-Czogalla, Katarzyna Piekarowicz, Katarzyna Wachowicz, Katarzyna Kozioł, Magda Dubińska-Magiera, Ryszard Rzepecki   +5 more
doaj   +1 more source

Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

Journal of Translational Medicine, 2023
Background Dilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on DCM have revealed diverse aetiologies.
Chia Yee Tan, Pui Shi Chan, Hansen Tan, Sung Wei Tan, Chang Jie Mick Lee, Jiong-Wei Wang, Shu Ye, Hendrikje Werner, Ying Jie Loh, Yin Loon Lee, Matthew Ackers-Johnson, Roger S. Y. Foo, Jianming Jiang   +12 more
doaj   +1 more source

A role for Tctex-1 (DYNLT1) in controlling primary cilium length [PDF]

, 2011
The microtubule motor complex cytoplasmic dynein is known to be involved in multiple processes including endomembrane organization and trafficking, mitosis, and microtubule organization.
MacCarthy-Morrogh, LJ, Miss Nicola, Smyllie, Palmer, KJ, Stephens, DJ   +3 more
core   +2 more sources

Cytoplasmic chromatin triggers inflammation in senescence and cancer [PDF]

, 2017
Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a ...
Adams, Peter D., Ahasan Al Tanim, K.M., Barber, Glen N., Berger, Shelley L., Capell, Brian C., Dou, Zhixun, Garcia, Benjamin A., Ghosh, Kanad, Jiang, Tianying, Kaestner, Klaus H., Kieckhaefer, Julia E., Lan, Yemin, Lin, Yanping, Millar, Sarah E., Sen, Payel, Seykora, John T., Shoshkes-Carmel, Michal, Simithy, Johayra, Vizioli, Maria Grazia, Wangensteen, Kirk J., Xu, Caiyue, Xu, Mingang, Zhou, Zhuo, Zhu, Jiajun   +23 more
core   +2 more sources