Results 51 to 60 of about 82,088 (275)

Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor Performance status.

PLoS ONE, 2017
The type V intermediate filament lamins are the principal components of the nuclear matrix, including the nuclear lamina. Lamins are divided into A-type and B-type, which are encoded by three genes, LMNA, LMNB1, and LMNB2.
Elise Kaspi, Diane Frankel, Julien Guinde, Sophie Perrin, Sophie Laroumagne, Andrée Robaglia-Schlupp, Kevin Ostacolo, Karim Harhouri, Rachid Tazi-Mezalek, Joelle Micallef, Hervé Dutau, Pascale Tomasini, Annachiara De Sandre-Giovannoli, Nicolas Lévy, Pierre Cau, Philippe Astoul, Patrice Roll   +16 more
doaj   +1 more source

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity [PDF]

, 2013
The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies ...
Chen GL, Pattison D, Wang H, Yoshida M
core   +1 more source

Mechanoregulatory Effects of Cell‐Scale Microwells on Epithelial Cell Phenotype

Advanced Functional Materials, EarlyView.
In small polycaprolactone microwells, A549 epithelial cells span well edges, in contrast to cells growing on flat substrates. Focal adhesion sites (yellow) concentrate at topographic boundaries, while cytoskeletal tension (magenta stress fibers) is transmitted to the nucleus (blue), reducing nuclear sphericity.
Ruiwen He, Wang Sik Lee, Phattadon Yajan, Aaron Lee, Mauro Sousa de Almeida, Sandeep Keshavan, Jozef Adamcik, Céline Loussert‐Fonta, Dimitri Vanhecke, Barbara Rothen‐Rutishauser, Alke Petri‐Fink   +10 more
wiley   +1 more source

Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope. [PDF]

PLoS ONE, 2014
Nuclear lamins are important structural and functional proteins in mammalian cells, but little is known about the mechanisms and cofactors that regulate their traffic into the nucleus.
Jose M González-Granado, Ana Navarro-Puche, Pedro Molina-Sanchez, Marta Blanco-Berrocal, Rosa Viana, Jaime Font de Mora, Vicente Andrés   +6 more
doaj   +1 more source

Sheet lamination

, 2022
The sheet lamination (SHL) is one of the processes in additive technologies. In the past, it has been used extensively to make fast, inexpensive paper prototypes. Then the application expanded to metals, polymers (only thermoplastics), textiles and ceramics, which also required the improvement of procedures, i.e. devices (3D printers).
openaire   +2 more sources

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes

Nature Communications
Barrier-to-autointegration factor (BAF) associates with mitotic chromosomes and promotes nuclear envelope assembly by recruiting proteins, such as Lamins, required for the reconstruction of the nuclear envelope and lamina.
Naoki Horikoshi, Ryosuke Miyake, Chizuru Sogawa-Fujiwara, Mitsuo Ogasawara, Yoshimasa Takizawa, Hitoshi Kurumizaka   +5 more
doaj   +1 more source

Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes [PDF]

, 2015
Beyond its role in providing structure to the nuclear envelope, lamin A/C is involved in transcriptional regulation. However, its cross talk with epigenetic factors--and how this cross talk influences physiological processes--is still unexplored.
Alessio Zippo, Alice Cortesi, Annagiusi Gargiulo, Asp, Ball, Bantignies, Bantignies, Beard, Beatrice Bodega, Bolte, Breiling, Caretti, Carpenter, Chiara Lanzuolo, Chiara Mozzetta, Cmarko, Cohen, Collas, Collins, Daniela Palacios, Delest, Dialynas, Elisa Cesarini, Fabrizia Marullo, Favreau, Francesco Gregoretti, Fredriksson, Frock, Gennaro Oliva, Gruenbaum, Gruenbaum, Harr, He, Hozák, Huang, Jahn, Juan, Kind, Kolb, Lanzuolo, Lanzuolo, Lanzuolo, Laura Antonelli, Lee, Lo Sardo, Lund, Marta Columbaro, Masny, Mattout, McCord, Melcon, Moir, Muñoz-Alarcón, Méjat, Oldenburg, Otsu, Palacios, Paro, Relaix, Riemer, Rosenblatt, Russ, Röber, Satijn, Scaffidi, Schiaffino, Schuettengruber, Schulze, Sezgin, Shimi, Shumaker, Simona Di Pelino, Solovei, Stefano Squarzoni, Stewart, Sullivan, Tolhuis, Trapnell, Wang, Wang, Woodhouse, Zaremba-Czogalla, Zwerger, Šmigová   +83 more
core   +1 more source

The Floor‐Ceiling‐Chip, or 2 × 2D = Pseudo‐3D—Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell‐Adhesive Protein Micropatterns

Advanced Healthcare Materials, EarlyView.
Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj, Francesca Giacomini, Esra Güben Kaçmaz, Tim ten Brink, Lorenzo Moroni, Zeinab Tahmasebi Birgani, Clemens van Blitterswijk, Pamela Habibović, Stefan Giselbrecht, Jan de Boer, Roman Truckenmüller   +10 more
wiley   +1 more source

Differential involvement of caspase-6 in amyloid-β-induced fragmentation of lamin A and B

Biochemistry and Biophysics Reports, 2020
Amyloid-β (Aβ), a peptide implicated in Alzheimer's disease, was shown to cause specific fragmentation of lamin proteins, which was mediated by an unidentified protease named nuclear scaffold protease (NSP) independently of caspase-6.
Md Imamul Islam, Md Selim Hossain, Il-Seon Park   +2 more
doaj   +1 more source