Results 1 to 10 of about 491 (128)
Indian Journal of Dental Research, 2009 Hutchinson Gilford Progeria Syndrome (HGPS) is a rare, sporadic, autosomal dominant syndrome that involves premature ageing and death at early age due to myocardial infarction or stroke.
Mohamed Riyaz S, Jayachandran S
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Dietary magnesium supplementation improves lifespan in a mouse model of progeria
EMBO Molecular Medicine, 2020 Aging is associated with redox imbalance according to the redox theory of aging. Consistently, a mouse model of premature aging (LmnaG609G/+) showed an increased level of mitochondrial reactive oxygen species (ROS) and a reduced basal antioxidant ...
Ricardo Villa‐Bellosta
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First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria
Advanced ScienceHutchinson‐Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by a mutation in the LMNA gene, leading to the production of progerin, an aberrant and toxic form of lamin A. Due to its hydrophobic nature, progerin accumulates at the nuclear
Jon Macicior‐Michelena +5 more
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Nucleus, 2023 Several related progeroid disorders are caused by defective post-translational processing of prelamin A, the precursor of the nuclear scaffold protein lamin A, encoded by LMNA.
Kamsi O. Odinammadu +5 more
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Progeria Presenting with Pyogenic Granuloma in Conjunctiva: A Case Report
Journal of Nepal Medical Association, 2023 Hutchinson-Gilford progeria syndrome frequently exhibits stunted growth and premature ageing. Notable ocular characteristics can encompass a large number of ocular abnormalities.
Sanket Parajuli +2 more
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Hereditary syndromes with signs of premature aging [PDF]
Остеопороз и остеопатии, 2020 Aging is a multi-factor biological process that inevitably affects everyone. Degenerative processes, starting at the cellular and molecular levels, gradually influence the change in the functional capabilities of all organs and systems.
Olga O. Golounina +2 more
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Progeria and Aging—Omics Based Comparative Analysis
Biomedicines, 2022 Since ancient times aging has also been regarded as a disease, and humankind has always strived to extend the natural lifespan. Analyzing the genes involved in aging and disease allows for finding important indicators and biological markers for ...
Aylin Caliskan +4 more
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Inguinal herniotomy in a patient with progeria
Journal of Pediatric Surgery Case Reports, 2020 Hutchinson–Gilford progeria syndrome or progeria is a rare finding, Herein, we report a 4-year- old boy with progeria who underwent herniotomy and herniorrhaphy for left indirect inguinal hernia.
Tanvir K. Chowdhury +3 more
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Journal of Medical Genetics, 1974 A pair of male monozygotic twins, both affected by progeria is described. The concordance in this manifestation suggests a genetic aetiology and other evidence indicates the implication of autosomal recessive factors; the chromosomes of these patients show no detectable abnormalities.
J, Viégas, P L, Souza, F M, Salzano
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Stem Cell Reports, 2020 Summary: Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder caused by a point mutation in the Lamin A gene that produces the protein progerin. Progerin toxicity leads to accelerated aging and death from cardiovascular disease.
Leigh Atchison +7 more
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