Results 31 to 40 of about 9,936 (203)
Pakistan Journal of Pharmaceutical Sciences, 2020 Hutchinson-Gilford progeria syndrome (or Progeria) is an exceptionally rare genetic disorder in children. It is caused by a rare point mutation in the lamin gene. It encodes lamin A protein, resulting in the de-shaping of nuclear membrane.
Bilal Ahmed +5 more
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The decision‐making process and criteria in selecting candidate drugs for progeria clinical trials
EMBO Molecular Medicine, 2016 Hutchinson–Gilford progeria syndrome (progeria) is an extremely rare premature aging disease with a population prevalence of 1 in 20 million. Nevertheless, propelled by the discovery of a causal mutation in the lamin A/C gene (LMNA) (De Sandre‐Giovannoli
Leslie B Gordon +3 more
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Early Onset Diabetes in Two Children due to Progeria, a Monogenic Disease of DNA Repair
JCRPE, 2020 Progeria syndrome is a rare disorder in childhood which causes accelerated systemic aging. Due to the accelerated aging process, disorders which normally occur only in old age will appear in these children at a much younger age.
Martin Holder, Valerie Schwitzgebel
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Nature Communications, 2020 Hutchinson-Gilford progeria syndrome is a genetic disease where an aberrant form of Lamin A disrupts chromatin by interfering with lamina associated domains.
Endre Sebestyén +11 more
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Conservatively managed extradural haematoma in a child with progeria
Interdisciplinary Neurosurgery, 2019 Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterised by premature ageing. We report a case of a 13-year-old girl with HGPS who presented with an extradural haematoma following head injury.
Kapil Mohan Rajwani +4 more
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The Potentials of Methylene Blue as an Anti-Aging Drug
Cells, 2021 Methylene blue (MB), as the first fully man-made medicine, has a wide range of clinical applications. Apart from its well-known applications in surgical staining, malaria, and methemoglobinemia, the anti-oxidative properties of MB recently brought new ...
Huijing Xue +2 more
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Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome [PDF]
, 2018 Aging, the main risk factor for cardiovascular disease (CVD), is becoming progressively more prevalent in our societies. A better understanding of how aging promotes CVD is therefore urgently needed to develop new strategies to reduce disease burden ...
del Campo, Lara +5 more
core +1 more source
Lessons in aging from Myc knockout mouse models
Frontiers in Cell and Developmental Biology, 2023 Despite MYC being among the most intensively studied oncogenes, its role in normal development has not been determined as Myc−/− mice do not survival beyond mid-gestation.
Edward V. Prochownik +4 more
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Implant Supported Prosthesis in a Patient with Progeria: Case Report
Biomolecules & Biomedicine, 2009 Prosthodontic rehabilitation can be accomplished with fixed, overdenture, complete, or implant-retained prostheses. Dental treatment overcomes the patient’s functional, psychological, esthetic and phonation problems.
Gözlem Ceylan +3 more
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Progeria (Hutchinson-Gilford Syndrome): Literature Review and Clinical Case
Вопросы современной педиатрии, 2022 Progeria, or Hutchinson-Gilford Syndrome is a rare disease from the group of laminopathies characterized by premature aging with skin, bones and cardiovascular system lesions.
Natalia V. Buchinskaya +3 more
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