Results 31 to 40 of about 7,451 (172)
Progeria in siblings: A rare case report
Indian Journal of Dermatology, 2011 Progeria, also known as Hutchinson-Gilford syndrome, is an extremely rare, severe genetic condition wherein symptoms resembling aspects of aging are manifested at an early age. It is an autosomal dominant disorder.
R Sowmiya, D Prabhavathy, S Jayakumar
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Early Onset Diabetes in Two Children due to Progeria, a Monogenic Disease of DNA Repair
JCRPE, 2020 Progeria syndrome is a rare disorder in childhood which causes accelerated systemic aging. Due to the accelerated aging process, disorders which normally occur only in old age will appear in these children at a much younger age.
Martin Holder, Valerie Schwitzgebel
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Nature Communications, 2020 Hutchinson-Gilford progeria syndrome is a genetic disease where an aberrant form of Lamin A disrupts chromatin by interfering with lamina associated domains.
Endre Sebestyén +11 more
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Dietary magnesium supplementation improves lifespan in a mouse model of progeria
EMBO Molecular Medicine, 2020 Aging is associated with redox imbalance according to the redox theory of aging. Consistently, a mouse model of premature aging (LmnaG609G/+) showed an increased level of mitochondrial reactive oxygen species (ROS) and a reduced basal antioxidant ...
Ricardo Villa‐Bellosta
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Implant Supported Prosthesis in a Patient with Progeria: Case Report
Biomolecules & Biomedicine, 2009 Prosthodontic rehabilitation can be accomplished with fixed, overdenture, complete, or implant-retained prostheses. Dental treatment overcomes the patient’s functional, psychological, esthetic and phonation problems.
Gözlem Ceylan +3 more
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The Potentials of Methylene Blue as an Anti-Aging Drug
Cells, 2021 Methylene blue (MB), as the first fully man-made medicine, has a wide range of clinical applications. Apart from its well-known applications in surgical staining, malaria, and methemoglobinemia, the anti-oxidative properties of MB recently brought new ...
Huijing Xue +2 more
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Journal of Lipid Research, 2009 Hutchinson-Gilford progeria syndrome (HGPS) is caused by the synthesis of a truncated prelamin A, commonly called progerin, that contains a carboxyl-terminal farnesyl lipid anchor.
Brandon S.J. Davies +10 more
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Lessons in aging from Myc knockout mouse models
Frontiers in Cell and Developmental Biology, 2023 Despite MYC being among the most intensively studied oncogenes, its role in normal development has not been determined as Myc−/− mice do not survival beyond mid-gestation.
Edward V. Prochownik +4 more
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Progeria (Hutchinson-Gilford Syndrome): Literature Review and Clinical Case
Вопросы современной педиатрии, 2022 Progeria, or Hutchinson-Gilford Syndrome is a rare disease from the group of laminopathies characterized by premature aging with skin, bones and cardiovascular system lesions.
Natalia V. Buchinskaya +3 more
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Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
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