Results 21 to 30 of about 7,451 (172)
Hereditary syndromes with signs of premature aging [PDF]
Остеопороз и остеопатии, 2020 Aging is a multi-factor biological process that inevitably affects everyone. Degenerative processes, starting at the cellular and molecular levels, gradually influence the change in the functional capabilities of all organs and systems.
Olga O. Golounina +2 more
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Progeria and Aging—Omics Based Comparative Analysis
Biomedicines, 2022 Since ancient times aging has also been regarded as a disease, and humankind has always strived to extend the natural lifespan. Analyzing the genes involved in aging and disease allows for finding important indicators and biological markers for ...
Aylin Caliskan +4 more
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Inguinal herniotomy in a patient with progeria
Journal of Pediatric Surgery Case Reports, 2020 Hutchinson–Gilford progeria syndrome or progeria is a rare finding, Herein, we report a 4-year- old boy with progeria who underwent herniotomy and herniorrhaphy for left indirect inguinal hernia.
Tanvir K. Chowdhury +3 more
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Journal of Medical Genetics, 1974 A pair of male monozygotic twins, both affected by progeria is described. The concordance in this manifestation suggests a genetic aetiology and other evidence indicates the implication of autosomal recessive factors; the chromosomes of these patients show no detectable abnormalities.
J, Viégas, P L, Souza, F M, Salzano
openaire +2 more sources
Cells, 2021 Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disease caused by a mutation in LMNA. A G608G mutation in exon 11 of LMNA is responsible for most HGPS cases, generating a truncated protein called “progerin”.
Jennifer M. Röhrl +2 more
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Premature aging of the body - the role of laminopathy [PDF]
Farmacja Polska, 2021 Aging is a process, that went off inevitable and it is associated with the accumulation of macromolecular damage, genomic instability, and loss of heterochromatin. All these changes conduct to deterioration function of stem cells and reducing the ability
Julia Wiśniewska +7 more
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Case of mandibuloacral dysplasia with type B lipodystrophy
Indian Journal of Paediatric Dermatology, 2021 Introduction: Mandibuloacral dysplasia with type B lipodystrophy (MADB) caused by compound heterozygous mutation in the ZMPSTE24 gene is characterized by generalized lipodystrophy and short stature.
Sanober Burzin Daruwalla +3 more
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Di-san junyi daxue xuebao, 2019 Objective To study the changes in the metabolic activity of brown adipose tissues in a mouse model of progeria using Cerenkov luminescence imaging. Methods 18F-FDG PET/CT imaging and Cerenkov luminescence imaging were used to dynamically monitor the ...
WANG Zhengjie +4 more
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The decision‐making process and criteria in selecting candidate drugs for progeria clinical trials
EMBO Molecular Medicine, 2016 Hutchinson–Gilford progeria syndrome (progeria) is an extremely rare premature aging disease with a population prevalence of 1 in 20 million. Nevertheless, propelled by the discovery of a causal mutation in the lamin A/C gene (LMNA) (De Sandre‐Giovannoli
Leslie B Gordon +3 more
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