Optical coherence tomography findings in three patients with Werner syndrome [PDF]
BMC Ophthalmology, 2022 Background Werner syndrome is a rare, autosomal recessive disorder characterised by premature aging. It is a typical hereditary progeroid syndrome that can be difficult to diagnose owing to its rarity and the similarity of some of its symptoms, such as ...
Tatsuya Nagai +7 more
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Innervated superficial circumflex iliac artery perforator flap for refractory elbow ulcer with bone exposure in Werner syndrome: A case report [PDF]
JPRAS OpenWerner syndrome is a rare autosomal recessive progeroid disorder first described by Werner and is characterized by premature aging, progressive cutaneous and subcutaneous atrophy, impaired wound healing, and premature arteriosclerosis, which contribute ...
Yuta Shimizu +7 more
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Case Report: A novel WRN mutation in Werner syndrome patient with diabetic foot disease and myelodysplastic syndrome [PDF]
Frontiers in Endocrinology, 2022 Werner syndrome is an autosomal recessive rare disease caused by a WRN gene mutation, which is rarely reported in the Chinese population. We report the clinical and genetic data of a Chinese patient with Werner syndrome.
Huifang Peng +7 more
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Werner syndrome presenting as early‐onset diabetes: A case report [PDF]
Journal of Diabetes Investigation, 2022 Werner syndrome is a rare autosomal recessive premature progeroid syndrome caused by mutations in the WRN gene. It is characterized by early onset of age‐related diseases, such as cataracts, atherosclerosis, diabetes mellitus, osteoporosis and ...
Xiaoli Wang +4 more
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Long-term follow-up of a case of bilateral elbow ulcers in a patient with Werner syndrome treated with pedicled radial forearm flaps [PDF]
Case Reports in Plastic Surgery & Hand SurgeryWerner syndrome is a rare autosomal recessive disorder caused by WRN gene mutations, leading to premature aging and genomic instability. Clinical symptoms include diabetes, skin lesions, and microvascular issues, with patients frequently developing ...
Yusuke Hayashibara +4 more
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Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome
Pharmaceuticals, 2010 Werner syndrome provides a convincing model for aspects of the normal ageing phenotype and may provide a suitable model for therapeutic interventions designed to combat the ageing process.
Mark C. Bagley +4 more
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Werner Syndrome Caused by Homozygous Frameshift Variant c.1578del in WRN [PDF]
Acta Medica LituanicaBackground. Progerias are rare hereditary genetic disorders that cause the onset of aging to occur earlier than generally expected, which initiates the progression of many age-related diseases.
Jovita Patricija Druta +3 more
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WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome [PDF]
Nature Communications, 2022 Short stature is a hallmark of Werner Syndrome, but the underlying mechanisms are not well studied. Here they report that WRN regulates bone development and growth by opening SHOX-G-quadruplexes via its helicase activity both in vitro and in vivo.
Yuyao Tian +9 more
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Proceedings of the Royal Society of Medicine, 1949 OCCASIONALLY the opportunity of seeing one of the rarer disease states or syndromes presents itself to most physicians. Their recognition can be made more readily possible if those who see them bring them to the attention of the profession. Our purpose in this paper is to add 2 more cases of Werner's syndrome to the literature, to review briefly the ...
J, SCHOTT, S, DANN
openaire +4 more sources
Herlyn-Werner-Wunderlich Syndrome: A Case Report
Journal of Nepal Medical Association, 2023 Herlyn-Werner-Wunderlich syndrome is a rare Mullerian and mesonephric ductal anomaly characterized by a triad of didelphys uterus, obstructed hemivagina, and ipsilateral renal agenesis complex.
Priyanka Vaidya +2 more
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