Results 21 to 30 of about 93,179 (152)
Microwave-assisted synthesis of a MK2 inhibitor by Suzuki-Miyaura coupling for study in Werner syndrome cells [PDF]
, 2015 Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquinoline
Bagley, Mark C +5 more
core +7 more sources
Herlyn-Werner-Wunderlich syndrome: A report of three cases in adolescents and adult woman
Radiology Case Reports, 2021 We report three cases with Herlyn-Werner-Wunderlich syndrome in adolescents and young female. The objective of this report was to describe the clinical presentation, ultrasound (US) and magnetic resonance imaging (MRI) findings of Herlyn-Werner ...
Quynh Vo Nhu, MD +2 more
doaj +1 more source
Exploration of Medicine, 2023 Progeroid syndromes are characterized by clinical signs of premature ageing, which may contain several diseases such as Werner syndrome, Bloom syndrome, Rothmund-Thomson syndrome, Hutchinson-Gilford progeria syndrome, and Cockayne syndrome.
Naoko Suga +3 more
doaj +1 more source
Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome
Pharmaceuticals, 2010 Werner syndrome provides a convincing model for aspects of the normal ageing phenotype and may provide a suitable model for therapeutic interventions designed to combat the ageing process.
Mark C. Bagley +4 more
doaj +1 more source
Herlyn-Werner-Wunderlich syndrome : a rare genitourinary anomaly in females : a series of four cases [PDF]
, 2018 We present case series of four patients with an important syndrome known as Herlyn-Werner-Wunderlich syndrome. Herlyn-Werner-Wunderlich syndrome is a rare congenital anomaly characterised by uterus didelphys with blind hemivagina and ipsilateral renal ...
Ilyas, Mohd +2 more
core +1 more source
Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome
Clinical Epigenetics, 2017 Background Werner syndrome is a progeroid disorder characterized by premature age-related phenotypes. Although it is well established that autosomal recessive mutations in the WRN gene is responsible for Werner syndrome, the molecular alterations that ...
T. Guastafierro +11 more
doaj +1 more source
Treatment of Virgin OHVIRA Syndrome with Haematometrocolpos by Complete Incision of Vaginal Septum without Hymenotomy [PDF]
Journal of Clinical and Diagnostic Research, 2015 Mullerian malformations result from defective fusion of the Mullerian ducts during development of the female reproductive system and have an incidence of 2-3%.
Niyazi Tug +4 more
doaj +1 more source
Hereditary syndromes with signs of premature aging [PDF]
Остеопороз и остеопатии, 2020 Aging is a multi-factor biological process that inevitably affects everyone. Degenerative processes, starting at the cellular and molecular levels, gradually influence the change in the functional capabilities of all organs and systems.
Olga O. Golounina +2 more
doaj +1 more source
Accelerated epigenetic aging in Werner syndrome. [PDF]
, 2017 Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased ...
Flunkert, Julia +5 more
core +1 more source
BMC Women's Health, 2018 Background Herlyn-Werner-Wunderlich syndrome is a very rare congenital genitourinary anomaly characterized by uterus didelphys, blind hemivagina and ipsilateral renal agenesis. Case presentation Authors present a case of Herlyn-Werner-Wunderlich syndrome
Hidayatullah Hamidi, Nilab Haidary
doaj +1 more source