Cosmetics, 2023 Our study aimed to develop a comprehensive approach to the management of patients with involutional skin changes, considering the predictors of premature skin aging.
Nikolai N. Potekaev +8 more
doaj +3 more sources
HMGA1-HP1β axis regulates premature aging in Hutchinson-Gilford progeria syndrome through chromatin remodeling [PDF]
Nature CommunicationsHutchinson‑Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by mutations in the LMNA gene. High mobility group A1 (HMGA1) exhibits differential expression patterns across aging models.
Qianying Hu +12 more
doaj +2 more sources
Chromosome duplication causes premature aging via defects in ribosome quality control. [PDF]
PLoS BiologyDown syndrome, caused by an extra copy of Chromosome 21, causes lifelong problems. One of the most common phenotypes among people with Down syndrome is premature aging, including early tissue decline, neurodegeneration, and shortened life span.
Leah E Escalante +7 more
doaj +2 more sources
Premature aging and metabolic diseases: the impact of telomere attrition [PDF]
Frontiers in AgingDriven by genetic and environmental factors, aging is a physiological process responsible for age-related degenerative changes in the body, cognitive decline, and impaired overall wellbeing.
Sandhya Jinesh +2 more
doaj +2 more sources
Gut microbial composition associated with risk of premature aging in women with Yin-deficiency constitution [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundYin-deficiency constitution (YinDC) refers to a traditional Chinese medicine concept, characterized by an imbalance state that includes an imbalance in the gut microbiota, resulting from a relative deficiency of Yin fluids within the body.
Yingying Zhai +15 more
doaj +2 more sources
Healthy and premature aging of monocytes and macrophages [PDF]
Frontiers in ImmunologyAging is associated with immunosenescence, a decline in immune functions, but also with inflammaging, a chronic, low-grade inflammation, contributing to immunosenescence.
Syamantak Basu +3 more
doaj +2 more sources
Molecular signatures of premature aging in Major Depression and Substance Use Disorders [PDF]
Scientific DataMajor depressive disorder (MDD) and substance-use disorders (SUDs) often lead to premature aging, increasing vulnerability to cognitive decline and other forms of dementia. This study utilized advanced systems bioinformatics to identify aging “signatures”
Anna Onisiforou +2 more
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Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination [PDF]
Nature CommunicationsAging accelerates central nervous system remyelination failure and neurodegeneration. Microglia promote remyelination by phagocytosing myelin debris, but this function is impaired by aging-related CD22 upregulation.
Weixing Yan +27 more
doaj +2 more sources
Canagliflozin ameliorates high-salt-induced renal injury and premature aging in male Dahl salt-sensitive rats, with associated changes in SIRT6/HIF-1α signaling [PDF]
Renal FailureSodium–glucose cotransporter 2 inhibitors (SGLT2is) exhibit renoprotective effects in diabetic and nondiabetic patients; however, the underlying mechanism remains unclear.
Qiuyan Wang +11 more
doaj +2 more sources
Connective tissue dysplasia as a predictor of premature skin aging
Russian Open Medical Journal, 2023 Background — One of the manifestations of connective tissue dysplasia (CTD) is premature skin aging. The latter can have different etiological factors.
Nikolai N. Potekaev +7 more
doaj +1 more source