Results 1 to 10 of about 241,214 (349)

COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? [PDF]

, 2020
COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East Respiratory Syndrome) family.
Auwerx, Blagosklonny, Blagosklonny, Blagosklonny, Colasurdo, Colson, Diaz-Quijano, Du, Erusalimsky, Gerontol, Gorospe, Hoffmann, Häkkinen, Jang, Li, Lisanti, Lisanti, Lu, Masternak, Munster, Musso, Nowakowski, Porter, Subbarao, Subbarao, Tanga, Tremblay, Wilce, Yaron, Yusof, Zhang   +30 more
core   +2 more sources

The intersection of TREX1, cGAS, STING and the DNA damage theory of aging

Frontiers in Aging
Genetic syndromes of immune dysregulation have opened a door toward understanding mechanisms linking inflammation, premature aging, and normal aging.
Kate M. Jones, Kate M. Jones, Samuel D. Chauvin, Samuel D. Chauvin, Jonathan J. Miner, Jonathan J. Miner, Jonathan J. Miner, Jonathan J. Miner, Jonathan J. Miner   +8 more
doaj   +1 more source

Effect of training on improving swimming biological age and capabilities of people aged 30-35 years

Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2014
Purpose: to verify the anti-aging effect of improving navigation on involution processes of the human body 30-35. Material: participation in the experiment took 43 men and women aged 30-35 years. Biological age is measured by the method of V.P. Voytenko.
N.V. Fedinyak
doaj   +1 more source

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom [PDF]

, 2018
Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these ...
Arnold, Walter, Johnson, Richard J., Kuro-o, Makoto, Lanaspa, Miguel, Painer, Johanna, Ruf, Thomas, Shiels, Paul G., Stenvinkel, Peter   +7 more
core   +1 more source

Cardiomyocyte‐Specific Plakophilin‐2 Loss Is Sufficient to Induce Aging and Senescence of Nonmyocytes: Relevance to Arrhythmogenic Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Pathogenic variants in PKP2 are the most common cause of familial arrhythmogenic right ventricular cardiomyopathy. This study tests whether plakophilin‐2 (PKP2) deficiency only in cardiomyocytes is sufficient to provoke premature aging and ...
Giorgia Bertoli, Kavya Phadke, Alessandro Cospito, Joanna Abi Rizk, Mingliang Zhang, Eleni Miliotou, Michael Cammer, Yan Deng, Valeria Mezzano, Mark Alu, Gyles Ward, Cynthia Loomis, Adriana Heguy, Feng‐Xia Liang, Eric M. Small, Irene de Lázaro, Mario Delmar   +16 more
doaj   +1 more source

GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging

Experimental and Molecular Medicine, 2018
Aging: Clues in nuclear proteins Abnormal versions of proteins that support the structure and function of the membrane of the cell nucleus are implicated in premature aging disorders, and also in normal aging.
Jin Young Lee, Kyung-Rok Yu, Byung-Chul Lee, Insung Kang, Jae-Jun Kim, Eui-Jung Jung, Hyung-Sik Kim, Yoojin Seo, Soon Won Choi, Kyung-Sun Kang   +9 more
doaj   +1 more source

A Case Report of Hutchinson-Gilford Progeria Syndrome

The Journal of Qazvin University of Medical Sciences, 2019
Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic condition occurs one in every 8 million live births. HGPS is characterized by premature aging in various organs.
Siamak Yaghoubi, Sareh Mohammadi, Leili Yekefallah, Alireza Taromiha, Ameneh Bagheri   +4 more
doaj   +1 more source

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism [PDF]

, 2018
C.L.-O. is supported by grants from the European Union (ERC-2016-ADG, DeAge); Ministerio de Economía y Competitividad (MINECO/FEDER: SAF2014-52413-R and SAF2017-87655-R); Instituto de Salud Carlos III (RTICC); Progeria Research Foundation (PRF2016-66 ...
Bárcena Fernández, Clea, Durand, S., Fernández García, María Teresa, Garabaya Fernández, Cecilia, Kroemer, Guido, López Otín, Carlos, Mariño García, Guillermo, Mayoral García, Pablo, Menéndez Caravia, Xurde, Moral Quirós, Pedro, Pérez Freije, José María, Rodríguez, Francisco   +11 more
core   +3 more sources

Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging

Stem Cell Reports, 2014
Werner syndrome (WS) patients exhibit premature aging predominantly in mesenchyme-derived tissues, but not in neural lineages, a consequence of telomere dysfunction and accelerated senescence.
Hoi-Hung Cheung, Xiaozhuo Liu, Lucile Canterel-Thouennon, Lu Li, Catherine Edmonson, Owen M. Rennert   +5 more
doaj   +1 more source

Premature aging and immune senescence in HIV-infected children [PDF]

, 2016
Objective: Several pieces of evidence indicate that HIV-infected adults undergo premature aging. The effect of HIV and antiretroviral therapy (ART) exposure on the aging process of HIV-infected children may be more deleterious since their immune system ...
Cam\uf3s, Mireia, DE ROSSI, Anita, Del Bianco, Paola, Fortuny, Cl\ue0udia, Freguja, Riccardo, Gianesin, Ketty, Giaquinto, Carlo, Mozzo, Elena, Noguera Julian, Antoni, Petrara, MARIA RAFFAELLA, Rampon, Osvalda, Zanchetta, Marisa   +11 more
core   +1 more source