Results 31 to 40 of about 9,691,387 (324)

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes

Aging Cell, 2018
International audienceHutchinson–Gilford progeria syndrome (HGPS) is a lethal premature aging that recapitulates many normal aging characteristics. This disorder is caused by mutation in the LMNA gene leading to the production of progerin which induces ...
Le Calvé, Benjamin, Ziegler, Dorian, Marine Warnier, Nadine Martin, Benjamin Le Calvé, David Vindrieux, Dorian V. Ziegler, Martin, Nadine, Djebali, Sophia, Martin O. Bergo, Bernard, David, Audrey Griveau, Griveau, Audrey, Vindrieux, David, Warnier, Marine, Clotilde Wiel, Sophia Djebali, Wiel, Clotilde, Bergo, Martin, Marvel, Jacqueline, David Bernard, Jacqueline Marvel   +21 more
core   +3 more sources

A Novel Class of FKBP12 Ligands Rescues Premature Aging Phenotypes Associated with Myotonic Dystrophy Type 1. [PDF]

Cells
Background: Myotonic dystrophy type 1 (DM1) is an autosomal dominant disorder clinically characterized by progressive muscular weakness and multisystem degeneration, which correlates with the size of CTG expansion and MBLN decrease.
García-Puga M, Gerenu G, Bargiela A, Espinosa-Espinosa J, Mosqueira-Martín L, Sagartzazu-Aizpurua M, Aizpurua JM, Vallejo-Illarramendi A, Artero R, López de Munain A, Matheu A.   +10 more
europepmc   +2 more sources

Chromosome duplication causes premature aging via defects in ribosome quality control. [PDF]

PLoS Biol
Down syndrome, caused by an extra copy of Chromosome 21, causes lifelong problems. One of the most common phenotypes among people with Down syndrome is premature aging, including early tissue decline, neurodegeneration, and shortened life span.
Escalante LE, Hose J, Ahrens JM, Howe H, Paulsen N, Liss SJ, Place M, Gasch AP.   +7 more
europepmc   +2 more sources

Nicotinamide riboside intervention alleviates hematopoietic system injury of ionizing radiation‐induced premature aging mice

Aging Cell, 2023
Radiotherapy destroys cancer cells and inevitably harms normal human tissues, causing delayed effects of acute radiation exposure (DEARE) and accelerating the aging process in most survivors.
Wenxuan Li, Xinyue Wang, Yinping Dong, Qidong Huo, Tongpeng Yue, Xin Wu, Lu Lu, Junling Zhang, Yu Zhao, Hui Dong, Deguan Li   +10 more
semanticscholar   +1 more source

Testicular aging, male fertility and beyond

Frontiers in Endocrinology, 2022
Normal spermatogenesis and sperm function are crucial for male fertility. The effects of healthy testicular aging and testicular premature aging on spermatogenesis, sperm function, and the spermatogenesis microenvironment cannot be ignored. Compared with
Shijue Dong, Chen Chen, Jiali Zhang, Yuan Gao, Xuhui Zeng, Xiaoning Zhang   +5 more
doaj   +1 more source

DNA repair‐deficient premature aging models display accelerated epigenetic age

Aging Cell, 2023
Several premature aging mouse models have been developed to study aging and identify interventions that can delay age‐related diseases. Yet, it is still unclear whether these models truly recapitulate natural aging.
Kevin Perez, A. Parras, Sara Pico, Cheyenne Rechsteiner, A. Haghani, R. Brooke, Calida Mrabti, Lucas Schoenfeldt, S. Horvath, Alejandro Ocampo   +9 more
semanticscholar   +1 more source

Obesity as a premature aging phenotype — implications for sarcopenic obesity

GeroScience, 2022
Obesity and aging have both seen dramatic increases in prevalence throughout society. This review seeks to highlight common pathologies that present with obesity, along with the underlying risk factors, that have remarkable similarity to what is observed
Emily Nunan, C. Wright, Oluwayemisi A. Semola, M. Subramanian, Priya Balasubramanian, Pamela C. Lovern, I. Fancher, Joshua T. Butcher   +7 more
semanticscholar   +1 more source

Premature aging in mice with error-prone protein synthesis

Science Advances, 2022
The main source of error in gene expression is messenger RNA decoding by the ribosome. Translational accuracy has been suggested on a purely correlative basis to positively coincide with maximum possible life span among different rodent species, but ...
Dimitri Shcherbakov, Martina Nigri, R. Akbergenov, Margarita Brilkova, Matilde Mantovani, Patricia Isnard Petit, A. Grimm, A. Karol, Youjin Teo, Adrián Cortés Sanchón, Yadhu Kumar, A. Eckert, K. Thiam, Petra Seebeck, D. Wolfer, E. Böttger   +15 more
semanticscholar   +1 more source

Decreased Enterobacteriaceae translocation due to gut microbiota remodeling mediates the alleviation of premature aging by a high‐fat diet

Aging Cell, 2022
Aging‐associated microbial dysbiosis exacerbates various disorders and dysfunctions, and is a major contributor to morbidity and mortality in the elderly, but the underlying cause of this aging‐related syndrome is confusing.
K. Xu, Yannan Guo, Yida Wang, Yujie Ren, V. Low, Sungyun Cho, Lu Ping, Ke-Xing Peng, Xia Li, Ying Qiu, Qingfei Liu, Zhongchi Li, Zhao Wang   +12 more
semanticscholar   +1 more source

Xeroderma pigmentosum: A model for human premature aging

Journal of Investigative Dermatology, 2021
Aging results from intrinsic changes (chronologic) and damage from external exposures (extrinsic) on the human body. The skin is ideal to visually differentiate their unique features.
E. Rizza, J. DiGiovanna, Sikandar G. Khan, D. Tamura, J. Jeskey, K. Kraemer   +5 more
semanticscholar   +1 more source