Results 31 to 40 of about 99,056 (254)

DNA-Related Pathways Defective in Human Premature Aging

The Scientific World Journal, 2002
One of the major issues in studies on aging is the choice of biological model system. The human premature aging disorders represent excellent model systems for the study of the normal aging process, which occurs at a much earlier stage in life in these ...
Vilhelm A. Bohr
doaj   +1 more source

Long-term exposure to polystyrene microplastics triggers premature testicular aging

Particle and Fibre Toxicology, 2023
Background Plastic pollution is greatly serious in the ocean and soil. Microplastics (MPs) degraded from plastic has threatened animals and humans health. The accumulation of MPs in the tissues and blood in animals and humans has been found.
Deyi Wu, Meng Zhang, Ting Ting Bao, Hainan Lan   +3 more
doaj   +1 more source

Premature aging, allostasis and restorgenesis [PDF]

Spinal Cord, 2013
I feel that the highlight of my research activities is bringing the topic of ‘premature morbidity and aging’ (senectus praecox), in people with spinal cord injury (SCI) and other disabilities, into public awareness ...
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Comprehensive Management of Premature Skin Aging: Current Strategies, Treatments, and Emerging Therapies

Journal of Education, Health and Sport
Introduction and Aim. Premature skin aging results from both intrinsic and extrinsic factors, requiring a comprehensive management strategy. This review evaluates current and emerging approaches for preventing and treating premature skin aging, focusing
Anna Ziobro, Katarzyna Camlet, Kinga Kocur, Paulina Lis   +3 more
doaj   +1 more source

NF-κB in premature aging

Aging, 2012
During decades, aging has been regarded as the consequence of a stochastic process caused by the accumulative effect of damaged molecules. However, recent experimental evidences have extended this view and suggested that aging also requires active signaling programs for the maintenance of the aged state [1].
Fernando G, Osorio, Carlos, López-Otín, José M P, Freije   +2 more
openaire   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

On occupational factors and premature aging (literature review)

Сибирский научный медицинский журнал
Quantitative characteristics of the impact of factors of the production environment (physical, chemical, biological), the severity and intensity of the labor process, their contribution to the deterioration of the health of the working contingent and the
O. A. Savchenko, I. I. Novikova, O. V. Plotnikova   +2 more
doaj   +1 more source

Mutations Involved in Premature-Ageing Syndromes

The Application of Clinical Genetics, 2021
Premature-ageing syndromes are a heterogeneous group of rare genetic disorders resembling features of accelerated ageing and resulting from mutations in genes coding for proteins required for nuclear lamina architecture, DNA repair and maintenance of genome stability, mitochondrial function and other cellular processes.
openaire   +6 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source