Results 1 to 10 of about 98,992 (166)

Cardiomyocyte‐Specific Plakophilin‐2 Loss Is Sufficient to Induce Aging and Senescence of Nonmyocytes: Relevance to Arrhythmogenic Cardiomyopathy [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Pathogenic variants in PKP2 are the most common cause of familial arrhythmogenic right ventricular cardiomyopathy. This study tests whether plakophilin‐2 (PKP2) deficiency only in cardiomyocytes is sufficient to provoke premature aging and ...
Giorgia Bertoli, Kavya Phadke, Alessandro Cospito, Joanna Abi Rizk, Mingliang Zhang, Eleni Miliotou, Michael Cammer, Yan Deng, Valeria Mezzano, Mark Alu, Gyles Ward, Cynthia Loomis, Adriana Heguy, Feng‐Xia Liang, Eric M. Small, Irene de Lázaro, Mario Delmar   +16 more
doaj   +2 more sources

Regional brain aging: premature aging of the domain general system predicts aphasia severity [PDF]

Communications Biology
Premature brain aging is associated with poorer cognitive reserve and lower resilience to injury. When there are focal brain lesions, brain regions may age at different rates within the same individual.
Natalie Busby, Sarah Newman-Norlund, Sara Sayers, Chris Rorden, Roger Newman-Norlund, Janina Wilmskoetter, Rebecca Roth, Sarah Wilson, Deena Schwen-Blackett, Sigfus Kristinsson, Alex Teghipco, Julius Fridriksson, Leonardo Bonilha   +12 more
doaj   +2 more sources

High Cardiorespiratory Fitness Protects against Molecular Impairments of Metabolism, Heart, and Brain with Higher Efficacy in Obesity-Induced Premature Aging [PDF]

Endocrinology and Metabolism, 2022
Background High cardiorespiratory fitness (CRF) protects against age-related diseases. However, the mechanisms mediating the protective effect of high intrinsic CRF against metabolic, cardiac, and brain impairments in non-obese versus obese conditions ...
Patcharapong Pantiya, Chanisa Thonusin, Natticha Sumneang, Benjamin Ongnok, Titikorn Chunchai, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Busarin Arunsak, Natthaphat Siri-Angkul, Sirawit Sriwichaiin, Nipon Chattipakorn, Siriporn C. Chattipakorn   +11 more
doaj   +1 more source

Connective tissue dysplasia as a predictor of premature skin aging

Russian Open Medical Journal, 2023
Background — One of the manifestations of connective tissue dysplasia (CTD) is premature skin aging. The latter can have different etiological factors.
Nikolai N. Potekaev, Olga B. Borzykh, Elena I. Karpova, Marina M. Petrova, Natalia A. Shnayder, Diana V. Dmitrenko, Maria A. Zatolokina, Olga M. Demina   +7 more
doaj   +1 more source

A New Approach toward the Management of Patients with Premature Skin Aging Using the Predictor Effect

Cosmetics, 2023
Our study aimed to develop a comprehensive approach to the management of patients with involutional skin changes, considering the predictors of premature skin aging.
Nikolai N. Potekaev, Olga B. Borzykh, Elena I. Karpova, Marina M. Petrova, Natalia A. Shnayder, Maria A. Zatolokina, Olga M. Demina, Diana V. Dmitrenko, Elena E. Timechko   +8 more
doaj   +1 more source

Testicular aging, male fertility and beyond

Frontiers in Endocrinology, 2022
Normal spermatogenesis and sperm function are crucial for male fertility. The effects of healthy testicular aging and testicular premature aging on spermatogenesis, sperm function, and the spermatogenesis microenvironment cannot be ignored. Compared with
Shijue Dong, Chen Chen, Jiali Zhang, Yuan Gao, Xuhui Zeng, Xiaoning Zhang   +5 more
doaj   +1 more source

Impact of age, antiretroviral therapy, and cancer on epigenetic aging in people living with HIV

Cancer Medicine, 2023
Background Premature aging has been identified as a global risk factor for cancer. Causes of premature aging are multifactorial, including inflammation, infection, chronic stress, and lifestyle factors.
Yulan Qing, Ricky Chan, Pingfu Fu, Jennifer Cullen, Alexander Miron, Jeffrey M. Jacobson, John Pink, Stanton L. Gerson   +7 more
doaj   +1 more source

Increased Brain Age Gap Estimate (BrainAGE) in Young Adults After Premature Birth

Frontiers in Aging Neuroscience, 2021
Recent evidence suggests increased metabolic and physiologic aging rates in premature-born adults. While the lasting consequences of premature birth on human brain development are known, its impact on brain aging remains unclear.
Dennis M. Hedderich, Dennis M. Hedderich, Aurore Menegaux, Aurore Menegaux, Benita Schmitz-Koep, Benita Schmitz-Koep, Rachel Nuttall, Rachel Nuttall, Rachel Nuttall, Juliana Zimmermann, Juliana Zimmermann, Sebastian C. Schneider, Sebastian C. Schneider, Josef G. Bäuml, Marcel Daamen, Marcel Daamen, Henning Boecker, Marko Wilke, Claus Zimmer, Claus Zimmer, Dieter Wolke, Dieter Wolke, Peter Bartmann, Christian Sorg, Christian Sorg, Christian Sorg, Christian Gaser, Christian Gaser   +27 more
doaj   +1 more source

Benign prostatic hyperplasia in a 23 year old man with progeroid syndrome

African Journal of Urology, 2018
Introduction: Progeroid syndromes are characterized by accelerated aging and early development of diseases typically associated with aging. Premature development of tumors including BPH, maybe observed in these patients, which can lead to significant ...
M. Ahmed, A.T. Lawal, A. Bello, A. Abubakar, H.Y. Maitama   +4 more
doaj   +1 more source

RETINOPATHY OF PREMATURITY AND MATERNAL AGE [PDF]

Retina, 2010
To determine the risk factors, especially maternal risk factors, associated with the development of retinopathy of prematurity (ROP) in premature babies.A matched case-control study involving premature patients was undertaken retrospectively. The case group consisted of premature babies with the subsequent development of ROP.
Wei-Chi, Wu, Frank Shih-Chang, Ong, Jane Zea-Chin, Kuo, Chi-Chun, Lai, Ning-Chia, Wang, Kuan-Jen, Chen, Yih-Shiou, Hwang, Tun-Lu, Chen, Chia-Pang, Shih   +8 more
openaire   +2 more sources