Results 21 to 30 of about 101,264 (202)

Benign prostatic hyperplasia in a 23 year old man with progeroid syndrome

African Journal of Urology, 2018
Introduction: Progeroid syndromes are characterized by accelerated aging and early development of diseases typically associated with aging. Premature development of tumors including BPH, maybe observed in these patients, which can lead to significant ...
M. Ahmed, A.T. Lawal, A. Bello, A. Abubakar, H.Y. Maitama   +4 more
doaj   +1 more source

Premature CD4+ T cell aging and its contribution to lymphopenia-induced proliferation of memory cells in autoimmune-prone non-obese diabetic mice.

PLoS ONE, 2014
Lymphopenia-induced proliferation (LIP), a mechanism to maintain a constant number of T cells in circulation, occurs in both normal aging and autoimmune disease.
Ting-Ting Sheu, Bor-Luen Chiang, Jui-Hung Yen, Wen-Chi Lin   +3 more
doaj   +1 more source

ON RADIATION-INDUCED AGING: ACCELERATED OR PREMATURE AGING

Radiation Protection Dosimetry, 2022
Abstract The concept of radiation-induced aging is revisited from the viewpoint of a mathematical model. The effect of radiation on carcinogenesis is treated based on the Armitage–Doll multi-stage theory. The formula obtained for cancer incidence rate indicates that radiation dose can be explained in terms of time.
Takahiro Wada, Tetsuhiro Kinugawa, Satoshi Tanaka   +2 more
openaire   +2 more sources

Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome

Protein & Cell, 2018
Hutchinson-Gilford progeria syndrome (HGPS) and Werner syndrome (WS) are two of the best characterized human progeroid syndromes. HGPS is caused by a point mutation in lamin A (LMNA) gene, resulting in the production of a truncated protein product ...
Zeming Wu, Weiqi Zhang, Moshi Song, Wei Wang, Gang Wei, Wei Li, Jinghui Lei, Yu Huang, Yanmei Sang, Piu Chan, Chang Chen, Jing Qu, Keiichiro Suzuki, Juan Carlos Izpisua Belmonte, Guang-Hui Liu   +14 more
doaj   +1 more source

A young testicular microenvironment protects Leydig cells against age‐related dysfunction in a mouse model of premature aging [PDF]

, 2018
Testicular Leydig cells (LCs) are the primary source of circulating androgen in men. As men age, circulating androgen levels decline. However, whether reduced LC steroidogenesis results from specific effects of aging within LCs or reflects degenerative ...
Frederiksen, H, Milne, L, Hadoke, P, Curley, Michael, Hadoke, Patrick, Curley, M, Smith, LB, Milne, Laura, Smith, S, Smith, Sarah, Jørgensen, Anne, Potter, Paul, Jørgensen, A, Potter, P, Frederiksen, Hanne, Smith, Lee B.   +15 more
core   +1 more source

Abnormal cortical development after premature birth shown by altered allometric scaling of brain growth. [PDF]

, 2006
BACKGROUND: We postulated that during ontogenesis cortical surface area and cerebral volume are related by a scaling law whose exponent gives a quantitative measure of cortical development.
Ajayi-Obe, M., Nadeem Saeed, Allsop, J. M., Boardman, J., Kennea, N, Morenike Ajayi-Obe, Dyet, L., Jaroslav Stark, Frances Cowan, Saeed Nadeem, Philip Duggan, Allsop Joanna M, Counsell, S. J.; id_orcid, Kennea, N., Ajayi-Obe Morenike, Stark, J., Edwards, AD, Cowan, F, Mary A Rutherford, Joanna M Allsop, Dyet Leigh, Counsell Serena J, Counsell, SJ, Stark, J, Kennea Nigel, Duggan Philip, Maalouf, E, Allsop, JM, Kapellou, O, Jo Hajnal, Leigh Dyet, Rutherford, M. A., Rutherford, MA, Duggan, P., Edwards, A. D.; id_orcid, Ajayi-Obe, M, Maalouf Elia, A David Edwards, Maalouf, E., Boardman James, Cowan, F., Hajnal, J.; id_orcid, Saeed, N, Dyet, L, James Boardman, Cowan Frances, Edwards A. David, Duggan, P, Rutherford Mary A, Hajnal Jo, Elia Maalouf, Olga Kapellou, Kapellou, O., Serena J Counsell, Saeed, N., Hajnal, J, Stark Jaroslav, Boardman, J, Nigel Kennea, Kapellou Olga   +59 more
core   +1 more source

The premature ageing syndromes: insights into the ageing process [PDF]

Age and Ageing, 1998
Ageing in man results from a complex interaction of genetic and environmental factors. Many overlapping and sometimes conflicting theories of ageing exist and the emergence of a unified theory still seems unlikely. Experimental studies of senescence are difficult to design because of the variable effect of diseases and other extrinsic factors.
C A, Dyer, A J, Sinclair
openaire   +2 more sources

Subjective Overview of Accelerated Aging in Schizophrenia

, 2022
Schizophrenia, like many other human diseases, particularly neuropsychiatric diseases, shows evidence of accelerated brain aging. The molecular nature of the process of aging is unknown but several potential indicators have been used in research.
Mary V. Seeman, Seeman, Mary V.
core   +1 more source

Premature or pathological aging: longevity

Brazilian Journal of Food Technology, 2017
The main objective of this literature review was to summarize and characterize the main factors and events that may negatively influence quality of life and human longevity.
Valdemiro Carlos Sgarbieri, Maria Teresa Bertoldo Pacheco   +1 more
doaj   +1 more source

Premature aging in telomerase-deficient zebrafish

Disease Models & Mechanisms, 2013
SUMMARY The study of telomere biology is crucial to the understanding of aging and cancer. In the pursuit of greater knowledge in the field of human telomere biology, the mouse has been used extensively as a model.
Monique Anchelin, Francisca Alcaraz-Pérez, Carlos M. Martínez, Manuel Bernabé-García, Victoriano Mulero, María L. Cayuela   +5 more
doaj   +1 more source