Results 11 to 20 of about 99,091 (265)
PLoS ONE, 2014 Lymphopenia-induced proliferation (LIP), a mechanism to maintain a constant number of T cells in circulation, occurs in both normal aging and autoimmune disease.
Ting-Ting Sheu +3 more
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PREMATURE AGING MARKERS IN WOMEN OF REPRODUCTIVE AGE WITH HYPOPITUITARISM
Alʹmanah Kliničeskoj Mediciny, 2016 Background: Premature aging reduces quality of human life, leads to development of “old age diseases” in younger age, and also shortens life expectancy.
D. S. Mikhaylova, I. A. Ilovayskaya
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ON RADIATION-INDUCED AGING: ACCELERATED OR PREMATURE AGING
Radiation Protection Dosimetry, 2022 Abstract The concept of radiation-induced aging is revisited from the viewpoint of a mathematical model. The effect of radiation on carcinogenesis is treated based on the Armitage–Doll multi-stage theory. The formula obtained for cancer incidence rate indicates that radiation dose can be explained in terms of time.
Takahiro Wada +2 more
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Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome
Protein & Cell, 2018 Hutchinson-Gilford progeria syndrome (HGPS) and Werner syndrome (WS) are two of the best characterized human progeroid syndromes. HGPS is caused by a point mutation in lamin A (LMNA) gene, resulting in the production of a truncated protein product ...
Zeming Wu +14 more
doaj +1 more source
The premature ageing syndromes: insights into the ageing process [PDF]
Age and Ageing, 1998 Ageing in man results from a complex interaction of genetic and environmental factors. Many overlapping and sometimes conflicting theories of ageing exist and the emergence of a unified theory still seems unlikely. Experimental studies of senescence are difficult to design because of the variable effect of diseases and other extrinsic factors.
C A, Dyer, A J, Sinclair
openaire +2 more sources
Premature aging in telomerase-deficient zebrafish
Disease Models & Mechanisms, 2013 SUMMARY The study of telomere biology is crucial to the understanding of aging and cancer. In the pursuit of greater knowledge in the field of human telomere biology, the mouse has been used extensively as a model.
Monique Anchelin +5 more
doaj +1 more source
Premature or pathological aging: longevity
Brazilian Journal of Food Technology, 2017 The main objective of this literature review was to summarize and characterize the main factors and events that may negatively influence quality of life and human longevity.
Valdemiro Carlos Sgarbieri +1 more
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MALONDIALDEHYDE (MDA) (ZAT OKSIDAN YANG MEMPERCEPAT PROSES PENUAAN)
Jurnal Keperawatan dan Fisioterapi, 2020 Malondialdehyde (MDA) is the end product of fat peroxidation due to the breakdown of fatty acid chains which are compounds that toxic to cells. Fat peroxidation is caused by body fat bound to free radicals such as hydroxyl radicals, superoxide anion ...
Novrina Situmorang, Zulham Zulham
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Premature aging in genetic diseases: what conclusions can be drawn for physiological aging
Frontiers in AgingAccording to current views the major hallmarks of physiological aging may be subdivided into three categories, primary causes of cellular damage (genomic instability, telomere attrition, loss of proteostasis, epigenetic alterations and compromised ...
Filip Milosic +2 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan +3 more
wiley +1 more source