Results 51 to 60 of about 99,056 (254)
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
The intersection of TREX1, cGAS, STING and the DNA damage theory of aging
Frontiers in AgingGenetic syndromes of immune dysregulation have opened a door toward understanding mechanisms linking inflammation, premature aging, and normal aging.
Kate M. Jones +8 more
doaj +1 more source
Biological Aging and Immune Senescence in Children with Perinatally Acquired HIV
Journal of Immunology Research, 2020 Chronic HIV-infected children suffer from premature aging and aging-related diseases. Viral replication induces an ongoing inflammation process, with the release of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns ...
Annalisa Dalzini +5 more
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Pathogenic variants in PKP2 are the most common cause of familial arrhythmogenic right ventricular cardiomyopathy. This study tests whether plakophilin‐2 (PKP2) deficiency only in cardiomyocytes is sufficient to provoke premature aging and ...
Giorgia Bertoli +16 more
doaj +1 more source
Effect of training on improving swimming biological age and capabilities of people aged 30-35 years
Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2014 Purpose: to verify the anti-aging effect of improving navigation on involution processes of the human body 30-35. Material: participation in the experiment took 43 men and women aged 30-35 years. Biological age is measured by the method of V.P. Voytenko.
N.V. Fedinyak
doaj +1 more source
Bone Research, 2023 A distinct population of skeletal stem/progenitor cells (SSPCs) has been identified that is indispensable for the maintenance and remodeling of the adult skeleton.
Ruici Yang +8 more
doaj +1 more source
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
Experimental and Molecular Medicine, 2018 Aging: Clues in nuclear proteins Abnormal versions of proteins that support the structure and function of the membrane of the cell nucleus are implicated in premature aging disorders, and also in normal aging.
Jin Young Lee +9 more
doaj +1 more source
A Case Report of Hutchinson-Gilford Progeria Syndrome
The Journal of Qazvin University of Medical Sciences, 2019 Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic condition occurs one in every 8 million live births. HGPS is characterized by premature aging in various organs.
Siamak Yaghoubi +4 more
doaj +1 more source