Results 51 to 60 of about 9,691,387 (324)

Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination. [PDF]

Nat Commun
Aging accelerates central nervous system remyelination failure and neurodegeneration. Microglia promote remyelination by phagocytosing myelin debris, but this function is impaired by aging-related CD22 upregulation.
Yan W, Zhao Y, Li H, Hong L, Jia Q, Zhu D, Xiang D, Du L, Hu L, Bai R, Xu M, Tang Y, Chen X, Cao Y, Jia W, Wang S, Liu Y, Ren J, Pan S, Shi Y, Gao S, Dong F, Shi J, Li J, Zheng K, Yang J, Zhao S, Wang H.   +27 more
europepmc   +2 more sources

The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes

Aging Cell, 2020
Hutchinson–Gilford progeria syndrome (HGPS) is caused by an LMNA mutation that results in the production of the abnormal progerin protein. Children with HGPS display phenotypes of premature aging and have an average lifespan of 13 years. We found earlier
A. Griveau, Clotilde Wiel, Dorian V Ziegler, M. Bergo, D. Bernard   +4 more
semanticscholar   +1 more source

Premature CD4+ T cell aging and its contribution to lymphopenia-induced proliferation of memory cells in autoimmune-prone non-obese diabetic mice.

PLoS ONE, 2014
Lymphopenia-induced proliferation (LIP), a mechanism to maintain a constant number of T cells in circulation, occurs in both normal aging and autoimmune disease.
Ting-Ting Sheu, Bor-Luen Chiang, Jui-Hung Yen, Wen-Chi Lin   +3 more
doaj   +1 more source

METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA

Nucleic Acids Research, 2020
N6-Methyladenosine (m6A) messenger RNA methylation is a well-known epitranscriptional regulatory mechanism affecting central biological processes, but its function in human cellular senescence remains uninvestigated.
Zeming Wu, Yue Shi, Mingming Lu, Moshi Song, Zihui Yu, Jilu Wang, Si Wang, Jie Ren, Yun-Gui Yang, Guang-Hui Liu, Weiqi Zhang, W. Ci, J. Qu   +12 more
semanticscholar   +1 more source

ON RADIATION-INDUCED AGING: ACCELERATED OR PREMATURE AGING

Radiation Protection Dosimetry, 2022
Abstract The concept of radiation-induced aging is revisited from the viewpoint of a mathematical model. The effect of radiation on carcinogenesis is treated based on the Armitage–Doll multi-stage theory. The formula obtained for cancer incidence rate indicates that radiation dose can be explained in terms of time.
Takahiro Wada, Tetsuhiro Kinugawa, Satoshi Tanaka   +2 more
openaire   +2 more sources

Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome

Protein & Cell, 2018
Hutchinson-Gilford progeria syndrome (HGPS) and Werner syndrome (WS) are two of the best characterized human progeroid syndromes. HGPS is caused by a point mutation in lamin A (LMNA) gene, resulting in the production of a truncated protein product ...
Zeming Wu, Weiqi Zhang, Moshi Song, Wei Wang, Gang Wei, Wei Li, Jinghui Lei, Yu Huang, Yanmei Sang, Piu Chan, Chang Chen, Jing Qu, Keiichiro Suzuki, Juan Carlos Izpisua Belmonte, Guang-Hui Liu   +14 more
doaj   +1 more source

A young testicular microenvironment protects Leydig cells against age‐related dysfunction in a mouse model of premature aging [PDF]

, 2018
Testicular Leydig cells (LCs) are the primary source of circulating androgen in men. As men age, circulating androgen levels decline. However, whether reduced LC steroidogenesis results from specific effects of aging within LCs or reflects degenerative ...
Frederiksen, H, Milne, L, Hadoke, P, Curley, Michael, Hadoke, Patrick, Curley, M, Smith, LB, Milne, Laura, Smith, S, Smith, Sarah, Jørgensen, Anne, Potter, Paul, Jørgensen, A, Potter, P, Frederiksen, Hanne, Smith, Lee B.   +15 more
core   +1 more source

eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction.

Cell Reports, 2021
Mitochondrial function declines during brain aging and is suspected to play a key role in age-induced cognitive decline and neurodegeneration. Supplementing levels of spermidine, a body-endogenous metabolite, has been shown to promote mitochondrial ...
YongTian Liang, Chengji Piao, C. Beuschel, David Toppe, L. Kollipara, Boris Bogdanow, M. Maglione, J. Lützkendorf, Jason Chun Kit See, Sheng Huang, T. Conrad, U. Kintscher, F. Madeo, Fan Liu, A. Sickmann, S. Sigrist   +15 more
semanticscholar   +1 more source

Abnormal cortical development after premature birth shown by altered allometric scaling of brain growth. [PDF]

, 2006
BACKGROUND: We postulated that during ontogenesis cortical surface area and cerebral volume are related by a scaling law whose exponent gives a quantitative measure of cortical development.
Ajayi-Obe, M., Nadeem Saeed, Allsop, J. M., Boardman, J., Kennea, N, Morenike Ajayi-Obe, Dyet, L., Jaroslav Stark, Frances Cowan, Saeed Nadeem, Philip Duggan, Allsop Joanna M, Counsell, S. J.; id_orcid, Kennea, N., Ajayi-Obe Morenike, Stark, J., Edwards, AD, Cowan, F, Mary A Rutherford, Joanna M Allsop, Dyet Leigh, Counsell Serena J, Counsell, SJ, Stark, J, Kennea Nigel, Duggan Philip, Maalouf, E, Allsop, JM, Kapellou, O, Jo Hajnal, Leigh Dyet, Rutherford, M. A., Rutherford, MA, Duggan, P., Edwards, A. D.; id_orcid, Ajayi-Obe, M, Maalouf Elia, A David Edwards, Maalouf, E., Boardman James, Cowan, F., Hajnal, J.; id_orcid, Saeed, N, Dyet, L, James Boardman, Cowan Frances, Edwards A. David, Duggan, P, Rutherford Mary A, Hajnal Jo, Elia Maalouf, Olga Kapellou, Kapellou, O., Serena J Counsell, Saeed, N., Hajnal, J, Stark Jaroslav, Boardman, J, Nigel Kennea, Kapellou Olga   +59 more
core   +1 more source

A dominant vimentin variant causes a rare syndrome with premature aging

European Journal of Human Genetics, 2020
Progeroid syndromes are a group of rare genetic disorders, which mimic natural aging. Unraveling the molecular defects in such conditions could impact our understanding of age-related syndromes such as Alzheimer’s or cardiovascular diseases.
B. Cogné, J. Bouameur, Gaëlle Hayot, X. Latypova, Sundararaghavan Pattabiraman, A. Caillaud, K. Si-Tayeb, T. Besnard, S. Küry, Caroline Chariau, A. Gaignerie, Laurent David, P. Bordure, Daniel Kaganovich, S. Bézieau, C. Golzio, T. Magin, B. Isidor   +17 more
semanticscholar   +1 more source