Results 51 to 60 of about 886,795 (250)

Are There Common Mechanisms Between the Hutchinson–Gilford Progeria Syndrome and Natural Aging?

Frontiers in Genetics, 2019
The Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disease caused by mutations of the LMNA gene leading to increased production of a partially processed form of the nuclear fibrillar protein lamin A – progerin.
Vasily V. Ashapkin, Lyudmila I. Kutueva, Svetlana Y. Kurchashova, Igor I. Kireev   +3 more
doaj   +1 more source

Loss of αklotho causes reduced motor ability and short lifespan in zebrafish

Scientific Reports, 2021
The klotho gene encodes a transmembrane protein αKlotho that interacts with a fibroblast growth factor (FGF) receptor in renal tubular epithelial cells and functions as a co-receptor for FGF23, which is an osteocytes-derived hormone.
Yurie Ogura, Ryoji Kaneko, Kota Ujibe, Yuma Wakamatsu, Hiromi Hirata   +4 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Cardiomyocyte‐Specific Plakophilin‐2 Loss Is Sufficient to Induce Aging and Senescence of Nonmyocytes: Relevance to Arrhythmogenic Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Pathogenic variants in PKP2 are the most common cause of familial arrhythmogenic right ventricular cardiomyopathy. This study tests whether plakophilin‐2 (PKP2) deficiency only in cardiomyocytes is sufficient to provoke premature aging and ...
Giorgia Bertoli, Kavya Phadke, Alessandro Cospito, Joanna Abi Rizk, Mingliang Zhang, Eleni Miliotou, Michael Cammer, Yan Deng, Valeria Mezzano, Mark Alu, Gyles Ward, Cynthia Loomis, Adriana Heguy, Feng‐Xia Liang, Eric M. Small, Irene de Lázaro, Mario Delmar   +16 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Biological Aging and Immune Senescence in Children with Perinatally Acquired HIV

Journal of Immunology Research, 2020
Chronic HIV-infected children suffer from premature aging and aging-related diseases. Viral replication induces an ongoing inflammation process, with the release of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns ...
Annalisa Dalzini, Maria Raffaella Petrara, Giovanni Ballin, Marisa Zanchetta, Carlo Giaquinto, Anita De Rossi   +5 more
doaj   +1 more source

Aging is a process that should be celebrated every day

, 2012
Jan. 12, 2012-; "... A blog-like publication that connects interest Ohioans to news and information about issues affecting older Ohioans and the people who care for and serve them."; Not published Feb.-Nov. 2013.; Issue for Jan.
Matura, Pamela K., Area Agency on Aging District 7   +1 more
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Ethical Foreground and Background in Adult Educator Work

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Adult educators work in a complex ethical environment. The very act of contributing to the learning of another is fraught with moral overtones. In this paper we consider the ethical dimensions of adult educator practice by distinguishing the ethical features of the context or ‘background’ of practice from the ethical capabilities and decision ...
Steven Hodge, Sonal Nakar
wiley   +1 more source

A Case Report of Hutchinson-Gilford Progeria Syndrome

The Journal of Qazvin University of Medical Sciences, 2019
Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic condition occurs one in every 8 million live births. HGPS is characterized by premature aging in various organs.
Siamak Yaghoubi, Sareh Mohammadi, Leili Yekefallah, Alireza Taromiha, Ameneh Bagheri   +4 more
doaj   +1 more source

Aging connection (Columbus, Ohio : Online)

, 2006
Monthly; Electronic coverage as of May 22, 2007: Mar. 2006-; Description based on Mar. 2006; title from Web page (viewed on May 22, 2007).; Harvested from the web on 5/22/07June 2006, Ohio Leads Nation in Senior Services Levy Revenue. Department of Aging
Ohio. Dept. of Aging
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