Results 71 to 80 of about 9,691,387 (324)
Aging as a consequence of misrepair -- A novel theory of aging
, 2009 It is now increasingly realized that the underlying mechanisms which govern aging is a complex interplay of genetic regulation and damage accumulation. Aging as a result of accumulation of ‘faults’ on cellular and molecular levels, has been
Arne Wunderlin +3 more
core +1 more source
DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging.
American Journal of Human Genetics, 2019 Genetic information is constantly being attacked by intrinsic and extrinsic damaging agents, such as reactive oxygen species, atmospheric radiation, environmental chemicals, and chemotherapeutics.
V. Tiwari, D. Wilson
semanticscholar +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Premature aging, allostasis and restorgenesis [PDF]
Spinal Cord, 2013 I feel that the highlight of my research activities is bringing the topic of ‘premature morbidity and aging’ (senectus praecox), in people with spinal cord injury (SCI) and other disabilities, into public awareness ...
openaire +2 more sources
Protein & Cell, 2019 Cockayne syndrome (CS) is a rare autosomal recessive inherited disorder characterized by a variety of clinical features, including increased sensitivity to sunlight, progressive neurological abnormalities, and the appearance of premature aging.
Si Wang +16 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Premature aging in Werner's syndrome spares the central nervous system
, 1996 Werner's Syndrome is a rare genetic disease, characterized by premature aging of many tissues and organs. We studied the brain morphology and function in two patients with Werner's syndrome to assess the possible involvement of the central nervous system
Alfredo Postiglione +11 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Journal of the Pakistan Medical AssociationObjective: To assess the relationship between light-emitting diode device usage and premature aging. Method: The cross-sectional, descriptive study was conducted from October 2023 to May 2024 after approval from the ethics review committee of Pakistan
Sadia Rehman +5 more
doaj +1 more source
Lung transcriptomic clock predicts premature aging in cigarette smoke-exposed mice
BMC Genomics, 2020 Background Lung aging is characterized by a number of structural alterations including fibrosis, chronic inflammation and the alteration of inflammatory cell composition. Chronic exposure to cigarette smoke (CS) is known to induce similar alterations and
M. Choukrallah +3 more
semanticscholar +1 more source