Results 71 to 80 of about 241,214 (349)

On occupational factors and premature aging (literature review)

Сибирский научный медицинский журнал
Quantitative characteristics of the impact of factors of the production environment (physical, chemical, biological), the severity and intensity of the labor process, their contribution to the deterioration of the health of the working contingent and the
O. A. Savchenko, I. I. Novikova, O. V. Plotnikova   +2 more
doaj   +1 more source

Cellular senescence and aging: the role of B-MYB [PDF]

, 2014
Cellular senescence is a stable cell cycle arrest, caused by insults, such as: telomere erosion, oncogene activation, irradiation, DNA damage, oxidative stress, and viral infection.
Jat, PS, Lam, EW, Mowla, SN
core   +1 more source

NF-κB in premature aging

Aging, 2012
During decades, aging has been regarded as the consequence of a stochastic process caused by the accumulative effect of damaged molecules. However, recent experimental evidences have extended this view and suggested that aging also requires active signaling programs for the maintenance of the aged state [1].
Fernando G, Osorio, Carlos, López-Otín, José M P, Freije   +2 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The role of peroxisome proliferator-activated receptor-coactivator-1 gene in skin aging

Journal of Research in Medical Sciences, 2016
Skin aging is a continuous process that exhibits fine and deep wrinkles, thin and transparent skin, loss of underlying fat, dry skin and itch, following decreased collagen and elastin synthesis.
Shahrzad Aghaei, Mohammad Ali Nilforoushzadeh, Maryam Aghaei   +2 more
doaj   +1 more source

Germline and somatic mtDNA mutations in mouse aging. [PDF]

PLoS ONE, 2018
The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans.
Hong Ma, Yeonmi Lee, Tomonari Hayama, Crystal Van Dyken, Nuria Marti-Gutierrez, Ying Li, Riffat Ahmed, Amy Koski, Eunju Kang, Hayley Darby, Thanasup Gonmanee, Younjung Park, Don P Wolf, Chong Jai Kim, Shoukhrat Mitalipov   +14 more
doaj   +1 more source

Deficiency of miR-29 a/b1 Leads to Premature Aging and Dopaminergic Neuroprotection in Mice [PDF]

, 2021
Xiaochen Bai, Jinghui Wang, Xiaoshuang Zhang, Yilin Tang, Linlin Han, Rong Fang, Zhaolin Liu, Hongtian Dong, Qing Li, Jingyu Ge, Yuanyuan Ma, Mei Yu, Ruilin Sun, Jian Wang, Jian Fei, Fang Huang   +15 more
openalex   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Loss of αklotho causes reduced motor ability and short lifespan in zebrafish

Scientific Reports, 2021
The klotho gene encodes a transmembrane protein αKlotho that interacts with a fibroblast growth factor (FGF) receptor in renal tubular epithelial cells and functions as a co-receptor for FGF23, which is an osteocytes-derived hormone.
Yurie Ogura, Ryoji Kaneko, Kota Ujibe, Yuma Wakamatsu, Hiromi Hirata   +4 more
doaj   +1 more source

Tissue-specific suppression of thyroid hormone signaling in various mouse models of aging [PDF]

, 2016
DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive.
Barnhoorn, S. (Sander), Boelen, A. (Anita), Bombardieri, C.R. (Cíntia R.), Brandt, R.M.C. (Renata), Darras, V.M. (Veerle), Dollé, M.E.T. (Martijn), Garinis, G.A. (George), Heerebeek, R. (Ramona) van, Hoeijmakers, J.H.J. (Jan), Horst, G.T.J. (Gijsbertus) van der, Kaptein, E. (Ellen), Kopchick, J.J. (John ), Krijger, R.R. (Ronald) de, Kwakkel, J. (Joan), List, E.O. (Edward O.), Medici, M. (Marco), Melis, J.P.M. (Joost), Ottaviani, A. (Alexandre), Peeters, R.P. (Robin), Pluijm, I. (Ingrid) van der, Toor, H. (Hans) van, Van Ham, W. (Willy), Vermeij, W.P. (Wilbert), Visser, T.J. (Theo), Visser, W.E. (Edward), Waard, M.C. (Monique) de, Zevenbergen, C. (Chantal)   +26 more
core   +1 more source