Results 81 to 90 of about 9,691,387 (324)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

NF-κB in premature aging

Aging, 2012
During decades, aging has been regarded as the consequence of a stochastic process caused by the accumulative effect of damaged molecules. However, recent experimental evidences have extended this view and suggested that aging also requires active signaling programs for the maintenance of the aged state [1].
Fernando G, Osorio, Carlos, López-Otín, José M P, Freije   +2 more
openaire   +2 more sources

Lower socioeconomic status is associated with premature brain aging

, 2023
Background Premature age-related brain changes may be influenced by physical health factors. Lower socioeconomic status (SES) is often associated with poorer physical health.
Nicholas Riccardi, Bonilha, Leonardo, Johnson, Lisa, Roger Newman-Norlund, Julius Fridriksson, Nemati, Samaneh, Roth, Rebecca, Sarah Newman-Norlund, Lisa Johnson, Leonardo Bonilha, Samaneh Nemati, den Ouden, Dirk B., Chris Rorden, Rorden, Chris, Sara Sayers, Riccardi, Nicholas, Sayers, Sara, Newman-Norlund, Roger, Wilson, Sarah, Natalie Busby, Newman-Norlund, Sarah, Rebecca Roth, Janina Wilmskoetter, Fridriksson, Julius, Busby, Natalie, Sarah Wilson, Dirk B. den Ouden, Wilmskoetter, Janina   +27 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Regional brain aging: premature aging of the domain general system predicts aphasia severity. [PDF]

Commun Biol
Premature brain aging is associated with poorer cognitive reserve and lower resilience to injury. When there are focal brain lesions, brain regions may age at different rates within the same individual.
Busby N, Newman-Norlund S, Sayers S, Rorden C, Newman-Norlund R, Wilmskoetter J, Roth R, Wilson S, Schwen-Blackett D, Kristinsson S, Teghipco A, Fridriksson J, Bonilha L.   +12 more
europepmc   +2 more sources

Early podocyte injury and premature glomerular aging - Supplemental Material

, 2023
Supplemental material for publication on early podocyte injury and premature glomerular aging.
Joseph C. Maggiore (17122728), Robert Allen Schweickart (17122729), Natalya Kaverina (17122758), Anthony Chang (17122772), Neil A. Hukriede (17122787), Yuting Zeng (17122725), Sierra R McKinzie (17122763), Carol J. Loretz (17122773), Beatriz Maria Veloso Pereira (17118214), Karina Thieme (17122784), Stuart J. Shankland (17122794), Diana G. Eng (6739319), Oliver Wessely (17122790), Jeffrey W. Pippin (6739329)   +13 more
core   +1 more source

Premature aging and cancer development in transgenic mice lacking functional CYLD

Aging, 2019
CYLD is a deubiquitinating enzyme known for its role as a tumor suppressor whose mutation leads to skin appendages tumors and other cancers. In this manuscript we report that the tumor suppressor CYLD, similarly to other renowned tumor suppressor genes ...
J. P. Alameda, Á. Ramírez, R. García-Fernández, M. Navarro, A. Page, J. Segovia, R. Sánchez, C. Suárez-Cabrera, J. Paramio, A. Bravo, M. Fernández-Aceñero, M. Casanova   +11 more
semanticscholar   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Comprehensive Management of Premature Skin Aging: Current Strategies, Treatments, and Emerging Therapies

Journal of Education, Health and Sport
Introduction and Aim. Premature skin aging results from both intrinsic and extrinsic factors, requiring a comprehensive management strategy. This review evaluates current and emerging approaches for preventing and treating premature skin aging, focusing
Anna Ziobro, Katarzyna Camlet, Kinga Kocur, Paulina Lis   +3 more
doaj   +1 more source