Results 61 to 70 of about 9,691,387 (324)
Journal of Investigative Dermatology, 2020 Defects in DNA repair pathways and alterations of mitochondrial energy metabolism have been reported in multiple skin disorders. More than ten percent of patients with primary mitochondrial dysfunction exhibit dermatological features including rashes and
M. Hussain +6 more
semanticscholar +1 more source
The premature ageing syndromes: insights into the ageing process [PDF]
Age and Ageing, 1998 Ageing in man results from a complex interaction of genetic and environmental factors. Many overlapping and sometimes conflicting theories of ageing exist and the emergence of a unified theory still seems unlikely. Experimental studies of senescence are difficult to design because of the variable effect of diseases and other extrinsic factors.
C A, Dyer, A J, Sinclair
openaire +2 more sources
Subjective Overview of Accelerated Aging in Schizophrenia
, 2022 Schizophrenia, like many other human diseases, particularly neuropsychiatric diseases, shows evidence of accelerated brain aging. The molecular nature of the process of aging is unknown but several potential indicators have been used in research.
Mary V. Seeman, Seeman, Mary V.
core +1 more source
Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation
Aging Cell, 2020 Damage to the genome can accelerate aging. The percentage of aneuploid cells, that is, cells with an abnormal number of chromosomes, increases during aging; however, it is not clear whether increased aneuploidy accelerates aging.
Harumi Fujita +13 more
semanticscholar +1 more source
Premature or pathological aging: longevity
Brazilian Journal of Food Technology, 2017 The main objective of this literature review was to summarize and characterize the main factors and events that may negatively influence quality of life and human longevity.
Valdemiro Carlos Sgarbieri +1 more
doaj +1 more source
Premature aging in telomerase-deficient zebrafish
Disease Models & Mechanisms, 2013 SUMMARY The study of telomere biology is crucial to the understanding of aging and cancer. In the pursuit of greater knowledge in the field of human telomere biology, the mouse has been used extensively as a model.
Monique Anchelin +5 more
doaj +1 more source
MALONDIALDEHYDE (MDA) (ZAT OKSIDAN YANG MEMPERCEPAT PROSES PENUAAN)
Jurnal Keperawatan dan Fisioterapi, 2020 Malondialdehyde (MDA) is the end product of fat peroxidation due to the breakdown of fatty acid chains which are compounds that toxic to cells. Fat peroxidation is caused by body fat bound to free radicals such as hydroxyl radicals, superoxide anion ...
Novrina Situmorang, Zulham Zulham
doaj +1 more source
Crosstalk between Oxidative Stress and Aging in Neurodegeneration Disorders
, 2023 The world population is aging rapidly, and increasing lifespan exacerbates the burden of age-related health issues. On the other hand, premature aging has begun to be a problem, with increasing numbers of younger people suffering aging-related symptoms ...
Seiichi Nagano, Rehab F. Abdelhamid
core +1 more source
Canagliflozin ameliorates high-salt-induced renal injury and premature aging in male Dahl salt-sensitive rats, with associated changes in SIRT6/HIF-1α signaling. [PDF]
Ren FailSodium–glucose cotransporter 2 inhibitors (SGLT2is) exhibit renoprotective effects in diabetic and nondiabetic patients; however, the underlying mechanism remains unclear.
Wang Q +11 more
europepmc +2 more sources
Cx3cr1-deficient microglia exhibit a premature aging transcriptome
Life Science Alliance, 2019 Gyoneva et al use RNA-seq to show that Cx3cr1-deficient microglia in young mice display a gene expression profile similar to microglia in aged mice, suggesting premature microglial aging.
Stefka Gyoneva +15 more
semanticscholar +1 more source