Results 11 to 20 of about 7,451 (172)
First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria [PDF]
Advanced ScienceHutchinson‐Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by a mutation in the LMNA gene, leading to the production of progerin, an aberrant and toxic form of lamin A. Due to its hydrophobic nature, progerin accumulates at the nuclear
Jon Macicior‐Michelena +5 more
doaj +3 more sources
Indian Journal of Dental Research, 2009 Hutchinson Gilford Progeria Syndrome (HGPS) is a rare, sporadic, autosomal dominant syndrome that involves premature ageing and death at early age due to myocardial infarction or stroke.
Mohamed Riyaz S, Jayachandran S
doaj +3 more sources
Stem Cell Reports, 2020 Summary: Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder caused by a point mutation in the Lamin A gene that produces the protein progerin. Progerin toxicity leads to accelerated aging and death from cardiovascular disease.
Leigh Atchison +2 more
exaly +3 more sources
Murine Progeria Model Exhibits Delayed Fracture Healing With Senescent Phenotype and Dysregulated Immune Response [PDF]
Journal of Orthopaedic Research, Volume 44, Issue 4, April 2026.Graphical Abstract This study explores whether a murine model of progeria has a delayed fracture healing phenotype that resembles chronological aging but with an accelerated timeline that could make it a valuable research tool. ABSTRACT An estimated 189 million bone fractures occurred in 2019 making it one of the most globally prevalent injuries ...
Victoria R. Duke +17 more
wiley +2 more sources
EMBO Molecular Medicine, 2021 Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilford progeria syndrome (HGPS). In this study, we present evidence of increased expression of the components of the NLRP3 inflammasome pathway in HGPS skin ...
Alvaro González-Domínguez +2 more
exaly +2 more sources
Selection of specific and efficient siRNAs in new cellular model for Hutchinson-Gilford progeria syndrome therapy [PDF]
Molecular Therapy: Nucleic AcidsHutchinson-Gilford progeria syndrome is a fatal genetic disorder caused by a point mutation in the gene encoding the nuclear envelope protein lamin A/C.
Volha Dzianisava +3 more
doaj +2 more sources
Nursing & Healthcare International JournalProgeria is a rare genetic disease with striking features that resemble accelerated aging. The inheritance pattern, paternal age effect, and lack of consanguinity argue that it is due to a sporadic dominant mutation. We have observed elevated levels of hyaluronic acid (HA) excretion in progeria patients.
Saleh HM, Sickles CK, Gross GP.
openaire +2 more sources
Mesenchymal Stem Cell Therapy for Hutchinson–Gilford Progeria: Improvements in Arterial Stiffness and Bone Mineral Density in a Single Case [PDF]
ChildrenBackground/Objectives: Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder that cause premature aging due to LMNA mutations and progerin accumulation.
Eun-Young Joo +6 more
doaj +2 more sources
Nucleus, 2023 Several related progeroid disorders are caused by defective post-translational processing of prelamin A, the precursor of the nuclear scaffold protein lamin A, encoded by LMNA.
Kamsi O. Odinammadu +5 more
doaj +1 more source
Progeria Presenting with Pyogenic Granuloma in Conjunctiva: A Case Report
Journal of Nepal Medical Association, 2023 Hutchinson-Gilford progeria syndrome frequently exhibits stunted growth and premature ageing. Notable ocular characteristics can encompass a large number of ocular abnormalities.
Sanket Parajuli +2 more
doaj +1 more source