Results 61 to 70 of about 54,589 (273)
NUP-1 is a large coiled-coil nucleoskeletal protein in Trypanosomes with lamin-like functions [PDF]
, 2012 A unifying feature of eukaryotic nuclear organization is genome segregation into transcriptionally active euchromatin and transcriptionally repressed heterochromatin.
Wan, Yakun +91 more
core +2 more sources
Advanced Science, EarlyView.BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai +7 more
wiley +1 more source
Mathematical Methods in the Applied Sciences, 2012 Laminates made of composite anisotropic layers have a large varieties of different possible elastic responses. Still remaining in the classical field of linear elasticity, it is possible to obtain, with laminates, elastic behaviors that are very strange and completely unusual not only for classical materials, like metallic alloys, but also for the same
openaire +3 more sources
Advanced Science, EarlyView.Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng +15 more
wiley +1 more source
Neuronal Lamin regulates motor circuit integrity and controls motor function and lifespan [PDF]
, 2018 Neuronal aging involves a progressive decline in cognitive abilities and loss of motor function. Mutations in human Lamin genes (LMNA, LMNB1, LMNB2) lead to a wide-range of diseases including muscular dystrophy, peripheral neuropathy and progeria.
Teleri Clark +6 more
core +1 more source
Advanced Science, EarlyView.An injectable and self‐reinforcing RSF‐based piezoelectric hydrogel conforms to irregular bone defects and progressively strengthens in situ, overcoming the trade‐off between injectability and mechanical stability. Mechanical loading generates bioelectrical cues that promote P300‐mediated H3K9 acetylation and upregulate PTH1R expression, thereby ...
Yu‐Kai Huang +15 more
wiley +1 more source
Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids
Advanced Science, EarlyView.This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia +8 more
wiley +1 more source
A proteomic and genomic investigation into the role of lamin A in colorectal cancer cell motility [PDF]
, 2012 Lamins are type V intermediate filament proteins found at the nuclear envelope. Expression of lamin A in colorectal cancer (CRC) tumours is correlated with poor prognosis and expression of lamin A in CRC cell lines promotes greatly increased cell ...
FOSTER, CLARE,RUTH, Foster, Clare Ruth
core
Advanced Science, EarlyView.PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao +8 more
wiley +1 more source
Lamin A/C as a prognostic biomarker in colorectal cancer [PDF]
, 2007 Lamins A and C (A-type lamins) are type V nuclear intermediate filament proteins which form a complex meshwork underlining the inner nuclear membrane termed the nuclear lamina.
Cox, Thomas Robert
core