Results 81 to 90 of about 43,097 (243)

The transcription factor Hey and nuclear lamins specify and maintain cell identity

eLife, 2019
The inability of differentiated cells to maintain their identity is a hallmark of age-related diseases. We found that the transcription factor Hey supervises the identity of differentiated enterocytes (ECs) in the adult Drosophila midgut. Lineage tracing
Naama Flint Brodsly, Eliya Bitman-Lotan, Olga Boico, Adi Shafat, Maria Monastirioti, Manfred Gessler, Christos Delidakis, Hector Rincon-Arano, Amir Orian   +8 more
doaj   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Lamin chromatin binding is modulated by interactions of different LAP2α domains with lamins and chromatin

iScience
Summary: Lamins A and C are components of the lamina at the nuclear periphery and associate with heterochromatin. A distinct, relatively mobile pool of lamin A/C in the nuclear interior associates with euchromatic regions and with lamin-associated ...
Daria Filipczak, Anna Souchet, Konstantina Georgiou, Roland Foisner, Nana Naetar   +4 more
doaj   +1 more source

Kaempferol Attenuates Myocardial Ischemia–Reperfusion Injury by Suppressing Ferroptosis via the KEAP1–Nrf2–GPX4 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Myocardial ischemia/reperfusion (I/R) injury is characterized by cardiomyocyte death, excessive oxidative stress, inflammation, and ferroptosis, which collectively limit the efficacy of reperfusion therapy. In this study, we investigated whether kaempferol (KAE), a natural flavonol with antioxidative and antiinflammatory properties, could ...
Yan‐Bo Zhao, Ling‐Ling Sun, Xiao‐Hua Shen, Min Wang, Mei‐Hui Wang, Lu‐Lu Liu, Kai Zhang   +6 more
wiley   +1 more source

Muscle‐Specific Kinase Signaling and Its Therapeutic Potential

Muscle &Nerve, EarlyView.
ABSTRACT The function of the neuromuscular junction (NMJ) is compromised in many neuromuscular diseases (NMDs) such as autoimmune or congenital myasthenia gravis (MG), amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), and muscular dystrophies.
Stine Marie Jensen, Dana L. E. Vergoossen, Maartje G. Huijbers   +2 more
wiley   +1 more source

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

PROTEOMICS, EarlyView.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling, Dounia Bouragba, Elisa Negroni, Capucine Trollet, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +6 more
wiley   +1 more source

Lamins regulate cancer cell plasticity and chemosensitivity

Frontiers in Oncology
BackgroundStem cell plasticity plays key roles in mammalian organogenesis, tissue homeostasis, and carcinogenesis. Given its tolerance to anti-tumor therapy and its promotion on immunosuppressive microenvironment, cancer cell plasticity is a major ...
Guofang Chen, Tingyi Wei, Tingyi Wei, Ao Huang, Junwei Shen, Furong Ju, Shichao Huang, Haisen Li, Haisen Li   +8 more
doaj   +1 more source

Toasting With Strangers? Export Spillovers From Chinese Winery Acquisitions in the Bordeaux Vineyards

British Journal of Management, EarlyView.
Abstract Foreign entrants may threaten and, at the same time, present local companies with opportunities for favourable spillovers. Building on the awareness‐motivation‐capability framework, this paper aims to provide empirical evidence for a positive co‐location or spatial proximity effect of foreign presence on local peer companies’ exports.
Pierre‐Xavier Meschi, Alexandre Bohas, Anne Norheim‐Hansen   +2 more
wiley   +1 more source

Measuring New Venture Legitimacy: A Multi‐dimensional Approach Using Computational Textual Analysis

British Journal of Management, EarlyView.
Abstract Legitimacy is critical for the growth, survival and performance of ventures, yet efforts to measure legitimacy empirically typically focus on a single dimension of this multi‐dimensional construct. In this article, we develop a multi‐dimensional framework for measuring legitimacy using computational text analysis.
Ali Ghods, Antonin Ricard, Bénédicte Aldebert, Eric W. Schoon   +3 more
wiley   +1 more source

Targeting nuclear export and Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signalling in myelofibrosis: A novel combinatorial strategy that impacts intrinsic and microenvironment‐related pathways

British Journal of Haematology, EarlyView.
Selinexor targets molecular pathways critical to myelofibrosis (MF) progenitor cell fitness and demonstrates complementary activity with ruxolitinib, supporting its potential as a novel disease‐modifying therapeutic strategy for MF. Summary Myelofibrosis (MF) is a chronic myeloproliferative neoplasm (MPN) characterized by splenomegaly, constitutional ...
Trinayan Kashyap, Andrea A. Ellero, Christopher J. Walker, Marie E. Maloof, Min Lu, Lijuan Xia, Ronald Hoffman, Pietro Taverna   +7 more
wiley   +1 more source