A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus [PDF]
Cell Reports, 2018 Summary: Tcrb locus V(D)J recombination is regulated by positioning at the nuclear periphery. Here, we used DamID to profile Tcrb locus interactions with the nuclear lamina at high resolution.
Shiwei Chen +7 more
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Restructuring of Lamina-Associated Domains in Senescence and Cancer
Cells, 2022 Induction of cellular senescence or cancer is associated with a reshaping of the nuclear envelope and a broad reorganization of heterochromatin. At the periphery of mammalian nuclei, heterochromatin is stabilized at the nuclear lamina via lamina ...
Aurélie Bellanger +3 more
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A Mechano-Feedback Loop Orchestrated by SUN1/2 Governs Cellular Mechanoadaptation via Lamina-Associated Domain Remodeling [PDF]
ResearchSUN1/2, core components of the linker of nucleoskeleton and cytoskeleton complex, transmit extracellular mechanical forces to nuclear lamina and chromatin.
Yafan Xie +11 more
doaj +2 more sources
Revealing the biophysics of lamina-associated domain formation by integrating theoretical modeling and high-resolution imaging [PDF]
Nature CommunicationsChromatin-lamina interactions regulate gene activity by forming lamina-associated domains (LADs), which contribute to cellular identity through gene repression.
Monika Dhankhar +9 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2022 Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical and mechanistic ...
Julia Madsen-Østerbye +5 more
doaj +3 more sources
Lamina Associated Domains and Gene Regulation in Development and Cancer
Cells, 2019 The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization.
Silke J. A. Lochs +2 more
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The assessment of posterior ocular structures in Turkish children with anisometropic amblyopia [PDF]
BMC OphthalmologyBackgrounds To investigate whether unilateral amblyopia in childhood is associated with structural alterations in the retina, optic nerve head, and lamina cribrosa by means of optical coherence tomography (OCT).
Elvin Halili Çelenk, Banu Torun Acar
doaj +2 more sources
Single Cell Mechanics in Disease Progression [PDF]
Small ScienceMechanical force transmission is essential for maintaining cellular structure and function. Forces generated by the extracellular matrix (ECM) and neighboring cells are transmitted via adhesion and junctional complexes to the cytoskeleton and nucleus ...
Sabin Kim +3 more
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Nuclear lamins are not required for lamina‐associated domain organization in mouse embryonic stem cells [PDF]
EMBO Reports, 2015 Bas van Steensel, Mario Amendola
exaly +2 more sources
Cellular and Genomic Features of Muscle Differentiation from Isogenic Fibroblasts and Myoblasts
Cells, 2023 The ability to recapitulate muscle differentiation in vitro enables the exploration of mechanisms underlying myogenesis and muscle diseases. However, obtaining myoblasts from patients with neuromuscular diseases or from healthy subjects poses ethical and
Louise Benarroch +9 more
doaj +1 more source