Results 1 to 10 of about 53,258 (212)

A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus [PDF]

Cell Reports, 2018
Summary: Tcrb locus V(D)J recombination is regulated by positioning at the nuclear periphery. Here, we used DamID to profile Tcrb locus interactions with the nuclear lamina at high resolution.
Shiwei Chen, Teresa Romeo Luperchio, Xianrong Wong, Europe B. Doan, Aaron T. Byrd, Kingshuk Roy Choudhury, Karen L. Reddy, Michael S. Krangel   +7 more
doaj   +4 more sources

A Mechano-Feedback Loop Orchestrated by SUN1/2 Governs Cellular Mechanoadaptation via Lamina-Associated Domain Remodeling [PDF]

Research
SUN1/2, core components of the linker of nucleoskeleton and cytoskeleton complex, transmit extracellular mechanical forces to nuclear lamina and chromatin.
Yafan Xie, Zhaoyan Zuo, Chenfei Lu, Yanjing Zhao, Liping Guo, Wei Xu, Fuhai Liu, Robert Guidoin, Haoyue Zhang, Juhui Qiu, Guixue Wang, Qin Peng   +11 more
doaj   +2 more sources

Restructuring of Lamina-Associated Domains in Senescence and Cancer

Cells, 2022
Induction of cellular senescence or cancer is associated with a reshaping of the nuclear envelope and a broad reorganization of heterochromatin. At the periphery of mammalian nuclei, heterochromatin is stabilized at the nuclear lamina via lamina ...
Aurélie Bellanger, Julia Madsen-Østerbye, Natalia M. Galigniana, Philippe Collas   +3 more
doaj   +3 more sources

Revealing the biophysics of lamina-associated domain formation by integrating theoretical modeling and high-resolution imaging [PDF]

Nature Communications
Chromatin-lamina interactions regulate gene activity by forming lamina-associated domains (LADs), which contribute to cellular identity through gene repression.
Monika Dhankhar, Zixian Guo, Aayush Kant, Ramin Basir, Rohit Joshi, Vinayak Vinayak, Su Chin Heo, Robert L. Mauck, Melike Lakadamyali, Vivek B. Shenoy   +9 more
doaj   +2 more sources

Lamina Associated Domains and Gene Regulation in Development and Cancer

Cells, 2019
The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization.
Silke J. A. Lochs, Samy Kefalopoulou, Jop Kind   +2 more
doaj   +3 more sources

Nuclear lamins are not required for lamina‐associated domain organization in mouse embryonic stem cells [PDF]

EMBO Reports, 2015
Bas Van Steensel, Mario Amendola
exaly   +2 more sources

Cellular and Genomic Features of Muscle Differentiation from Isogenic Fibroblasts and Myoblasts

Cells, 2023
The ability to recapitulate muscle differentiation in vitro enables the exploration of mechanisms underlying myogenesis and muscle diseases. However, obtaining myoblasts from patients with neuromuscular diseases or from healthy subjects poses ethical and
Louise Benarroch, Julia Madsen-Østerbye, Mohamed Abdelhalim, Kamel Mamchaoui, Jessica Ohana, Anne Bigot, Vincent Mouly, Gisèle Bonne, Anne T. Bertrand, Philippe Collas   +9 more
doaj   +1 more source

Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions

Frontiers in Cell and Developmental Biology, 2022
Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical and mechanistic ...
Julia Madsen-Østerbye, Aurélie Bellanger, Natalia M. Galigniana, Natalia M. Galigniana, Philippe Collas, Philippe Collas   +5 more
doaj   +1 more source

Local euchromatin enrichment in lamina-associated domains anticipates their repositioning in the adipogenic lineage

Genome Biology, 2022
Background Interactions of chromatin with the nuclear lamina via lamina-associated domains (LADs) confer structural stability to the genome. The dynamics of positioning of LADs during differentiation, and how LADs impinge on developmental gene expression,
Julia Madsen-Østerbye, Mohamed Abdelhalim, Marie-Odile Baudement, Philippe Collas   +3 more
doaj   +1 more source

Non-canonical Drosophila X chromosome dosage compensation and repressive topologically associated domains

Epigenetics & Chromatin, 2018
Background In animals with XY sex chromosomes, X-linked genes from a single X chromosome in males are imbalanced relative to autosomal genes. To minimize the impact of genic imbalance in male Drosophila, there is a dosage compensation complex (MSL) that ...
Hangnoh Lee, Brian Oliver
doaj   +1 more source