Results 1 to 10 of about 10,232,392 (268)
Genome Biology, 2022 Background Interactions of chromatin with the nuclear lamina via lamina-associated domains (LADs) confer structural stability to the genome. The dynamics of positioning of LADs during differentiation, and how LADs impinge on developmental gene expression,
Julia Madsen-Østerbye +3 more
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Role of histone deacetylases in gene regulation at nuclear lamina.
PLoS ONE, 2012 Theoretical models suggest that gene silencing at the nuclear periphery may involve "closing" of chromatin by transcriptional repressors, such as histone deacetylases (HDACs). Here we provide experimental evidence confirming these predictions.
Beatrice C Milon +7 more
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Epigenetics & Chromatin, 2018 Background In animals with XY sex chromosomes, X-linked genes from a single X chromosome in males are imbalanced relative to autosomal genes. To minimize the impact of genic imbalance in male Drosophila, there is a dosage compensation complex (MSL) that ...
Hangnoh Lee, Brian Oliver
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Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners. [PDF]
PLoS ONE, 2009 Nuclear lamin filaments and associated proteins form a nucleoskeletal ("lamina") network required for transcription, replication, chromatin organization and epigenetic regulation in metazoans.
Rocío Montes de Oca +4 more
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Optic nerve cavitations in glaucoma suspect and glaucoma patients
American Journal of Ophthalmology Case Reports, 2022 Purpose: Glaucoma is associated with structural changes of the optic nerve head such as deformation, lamina cribosa defects, prelaminar schisis, and peripapillary retinal schisis. We describe optic nerve cavitations that were detected by routine spectral
Bennett Y. Hong +5 more
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Optic disc microvasculature dropout in primary open-angle glaucoma measured with optical coherence tomography angiography. [PDF]
PLoS ONE, 2018 PURPOSE:To evaluate microvasculature dropout in the optic disc (Mvd-D) using optical coherence tomography angiography (OCTA) and investigate factors associated with Mvd-D in primary open-angle glaucoma (POAG) eyes.
Tadamichi Akagi +8 more
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Frontiers in Genetics, 2019 Many mammalian genes exhibit circadian expression patterns concordant with periodic binding of transcription factors, chromatin modifications, and chromosomal interactions. Here we investigate whether chromatin periodically associates with nuclear lamins.
Annaël Brunet +5 more
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The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate. [PDF]
PLoS ONE, 2013 Protein phosphatase 1 (PP1) binding proteins are quintessential regulators, determining substrate specificity and defining subcellular localization and activity of the latter.
Mariana Santos +7 more
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Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies
Nucleus, 2020 Decades of studies have established that nuclear lamin polymers form the nuclear lamina, a protein meshwork that supports the nuclear envelope structure and tethers heterochromatin to the nuclear periphery.
Sunny Yang Liu, Kohta Ikegami
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Role of lamins in 3D genome organization and global gene expression
Nucleus, 2019 Genome-wide mapping of lamin-B1-genome interactions has shown that gene-poor and transcriptionally inactive genomic regions are associated with the nuclear lamina.
Youngjo Kim, Xiaobin Zheng, Yixian Zheng
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